Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation
Нема приказа
Аутори
Basta-Jovanović, Gordana
Bogdanović, Ljiljana
Radunović, Milena

Prostran, Milica S.
Naumović, R.
Simić-Ogrizović, Sanja

Radojević-Škodrić, Sanja
Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant ...periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.
Кључне речи:
Acute Kidney Injury / Kidney transplantation / Acute renal failure / NGAL / Cystatin C / KIM-1 / IL-18 / L-FABPИзвор:
Current Medicinal Chemistry, 2016, 23, 19, 2012-2017Издавач:
- Bentham Science Publ Ltd, Sharjah
Финансирање / пројекти:
- Ћелијске и молекулске основе малигних и кардиоваскуларних обољења-клиничке импликације (RS-41027)
- Оптичко микроскопска, имуноморфолошка, молекуларно-биолошка и генетска испитивања малигних и немалигних болести бубрега (RS-175059)
DOI: 10.2174/092986732319160719192019
ISSN: 0929-8673
PubMed: 27498898
WoS: 000380786400007
Scopus: 2-s2.0-84981156738
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Basta-Jovanović, Gordana AU - Bogdanović, Ljiljana AU - Radunović, Milena AU - Prostran, Milica S. AU - Naumović, R. AU - Simić-Ogrizović, Sanja AU - Radojević-Škodrić, Sanja PY - 2016 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2094 AB - Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard. PB - Bentham Science Publ Ltd, Sharjah T2 - Current Medicinal Chemistry T1 - Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation VL - 23 IS - 19 SP - 2012 EP - 2017 DO - 10.2174/092986732319160719192019 ER -
@article{ author = "Basta-Jovanović, Gordana and Bogdanović, Ljiljana and Radunović, Milena and Prostran, Milica S. and Naumović, R. and Simić-Ogrizović, Sanja and Radojević-Škodrić, Sanja", year = "2016", abstract = "Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Current Medicinal Chemistry", title = "Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation", volume = "23", number = "19", pages = "2012-2017", doi = "10.2174/092986732319160719192019" }
Basta-Jovanović, G., Bogdanović, L., Radunović, M., Prostran, M. S., Naumović, R., Simić-Ogrizović, S.,& Radojević-Škodrić, S.. (2016). Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation. in Current Medicinal Chemistry Bentham Science Publ Ltd, Sharjah., 23(19), 2012-2017. https://doi.org/10.2174/092986732319160719192019
Basta-Jovanović G, Bogdanović L, Radunović M, Prostran MS, Naumović R, Simić-Ogrizović S, Radojević-Škodrić S. Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation. in Current Medicinal Chemistry. 2016;23(19):2012-2017. doi:10.2174/092986732319160719192019 .
Basta-Jovanović, Gordana, Bogdanović, Ljiljana, Radunović, Milena, Prostran, Milica S., Naumović, R., Simić-Ogrizović, Sanja, Radojević-Škodrić, Sanja, "Acute Renal Failure - A Serious Complication in Patients After Kidney Transplantation" in Current Medicinal Chemistry, 23, no. 19 (2016):2012-2017, https://doi.org/10.2174/092986732319160719192019 . .