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dc.creatorJuloski, Jovana
dc.creatorDumancić, Jelena
dc.creatorŠćepan, Ivana
dc.creatorLauc, Tomislav
dc.creatorMilašin, Jelena
dc.creatorKaić, Zvonimir
dc.creatorDumić, Miroslav
dc.creatorBabić, Marko
dc.date.accessioned2020-07-02T13:03:46Z
dc.date.available2020-07-02T13:03:46Z
dc.date.issued2016
dc.identifier.issn0003-9969
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/2099
dc.description.abstractObjective: Turner syndrome occurs in phenotypic females with complete or partial absence of X chromosome. The leading symptom is short stature, while numerous but mild stigmata manifest in the craniofacial region. These patients are commonly treated with growth hormone to improve their final height. The aim of this study was to assess the influence of long-term growth hormone therapy on craniofacial morphology in Turner syndrome patients. Design: In this cross-sectional study cephalometric analysis was performed on 13 lateral cephalograms of patients with 45,X karyotype and the average age of 17.3 years, who have received growth hormone for at least two years. The control group consisted of 13 Turner syndrome patients naive to growth hormone treatment, matched to study group by age and karyotype. Sixteen linear and angular measurements were obtained from standard lateral cephalograms. Standard deviation scores were calculated in order to evaluate influence of growth hormone therapy on craniofacial components. Results: In Turner syndrome patients treated with growth hormone most of linear measurements were significantly larger compared to untreated patients. Growth hormone therapy mainly influenced posterior face height, mandibular ramus height, total mandibular length, anterior face height and maxillary length. While the increase in linear measurements was evident, angular measurements and facial height ratio did not show statistically significant difference. Acromegalic features were not found. Conclusions: Long-term growth hormone therapy has positive influence on craniofacial development in Turner syndrome patients, with the greatest impact on posterior facial height and mandibular ramus. However, it could not compensate X chromosome deficiency and normalize craniofacial features.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS//
dc.relationCroatian Ministry of Science and TechnologyMinistry of Science, Education and Sports, Republic of Croatia [3-02-383]
dc.rightsrestrictedAccess
dc.sourceArchives of Oral Biology
dc.subjectMonosomy Xen
dc.subjectCephalometryen
dc.subjectMaxillofacial developmenten
dc.subjectHuman growth hormoneen
dc.subjectX chromosomeen
dc.subjectMandibleen
dc.titleGrowth hormone positive effects on craniofacial complex in Turner syndromeen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДумић, Мирослав; Каић, Звонимир; Думанцић, Јелена; Бабић, Марко; Шћепан, Ивана; Милашин, Јелена; Лауц, Томислав; Јулоски, Јована;
dc.citation.volume71
dc.citation.spage10
dc.citation.epage15
dc.citation.other71: 10-15
dc.citation.rankM22
dc.identifier.wos000385328200002
dc.identifier.doi10.1016/j.archoralbio.2016.06.012
dc.identifier.pmid27372203
dc.identifier.scopus2-s2.0-84976889239
dc.identifier.rcubconv_3393
dc.type.versionpublishedVersion


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