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dc.creatorBracanović, Đurđa
dc.creatorĐonić, Danijela
dc.creatorNikolić, Slobodan
dc.creatorMilovanović, Petar
dc.creatorRakočević, Zoran
dc.creatorŽivković, Vladimir
dc.creatorĐurić, Marija
dc.date.accessioned2020-07-02T13:04:08Z
dc.date.available2020-07-02T13:04:08Z
dc.date.issued2016
dc.identifier.issn0021-8782
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/2105
dc.description.abstractAlthough seen frequently during dissections and autopsies, Hyperostosis frontalis interna (HFI) - a morphological pattern of the frontal bone thickening - is often ignored and its nature and development are not yet understood sufficiently. Current macroscopic classification defines four grades/stages of HFI based on the morphological appearance and size of the affected area; however, it is unclear if these stages also depict the successive phases in the HFI development. Here we assessed 3D-microarchitecture of the frontal bone in women with various degrees of HFI expression and in an age- and sex-matched control group, hypothesizing that the bone microarchitecture bears imprints of the pathogenesis of HFI and may clarify the phases of its development. Frontal bone samples were collected during routine autopsies from 20 women with HFI (age: 69.9 +/- 11.1years) and 14 women without HFI (age: 74.1 +/- 9.7years). We classified the HFI samples into four groups, each group demonstrating different macroscopic type or stage of HFI. All samples were scanned by micro-computed tomography to evaluate 3D bone microarchitecture in the following regions of interest: total sample, outer table, diploe and inner table. Our results revealed that, compared to the control group, the women with HFI showed a significantly increased bone volume fraction in the region of diploe, along with significantly thicker and more plate-like shaped trabeculae and reduced trabecular separation and connectivity density. Moreover, the inner table of the frontal bone in women with HFI displayed significantly increased total porosity and mean pore diameter compared to controls. Microstructural reorganization of the frontal bone in women with HFI was also reflected in significantly higher porosity and lower bone volume fraction in the inner vs. outer table due to an increased number of pores larger than 100m. The individual comparisons between the control group and different macroscopic stages of HFI revealed significant differences only between the control group and the morphologically most pronounced type of HFI. Our microarchitectural findings demonstrated clear differences between the HFI and the control group in the region of diploe and the inner table. Macroscopic grades of HFI could not be distinguished at the level of bone microarchitecture and their consecutive nature cannot be supported. Rather, our study suggests that only two different types of HFI (moderate and severe HFI) have microstructural justification and should be considered further. It is essential to record HFI systematically in human postmortem subjects to provide more data on the mechanisms of its development.en
dc.publisherWiley-Blackwell, Hoboken
dc.relationMinistry of Science and Technology of the Republic of Serbia
dc.rightsopenAccess
dc.sourceJournal of Anatomy
dc.subjectfrontal boneen
dc.subjecthyperostosisen
dc.subjectmicro-architectureen
dc.subjectwomenen
dc.title3D-Microarchitectural patterns of Hyperostosis frontalis interna: a micro-computed tomography study in aged womenen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБрацановић, Ђурђа; Ђонић, Данијела; Ракочевић, Зоран; Ђурић, Марија; Миловановић, Петар; Живковић, Владимир; Николић, Слободан;
dc.citation.volume229
dc.citation.issue5
dc.citation.spage673
dc.citation.epage680
dc.citation.other229(5): 673-680
dc.citation.rankM21
dc.identifier.wos000386073000006
dc.identifier.doi10.1111/joa.12506
dc.identifier.pmid27279170
dc.identifier.scopus2-s2.0-84990243356
dc.identifier.fulltexthttps://smile.stomf.bg.ac.rs/bitstream/id/3393/2100.pdf
dc.identifier.rcubconv_3397
dc.type.versionpublishedVersion


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