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dc.creatorČarkić, Jelena
dc.creatorNikolić, Nadja
dc.creatorRadojević-Škodrić, Sanja
dc.creatorKuzmanović-Pfićer, Jovana
dc.creatorBrajović, Gavrilo
dc.creatorAntunović, Marija
dc.creatorMilašin, Jelena
dc.creatorPopović, Branka
dc.date.accessioned2020-07-02T13:04:45Z
dc.date.available2020-07-02T13:04:45Z
dc.date.issued2016
dc.identifier.issn1343-4934
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/2115
dc.description.abstractThe aim of this study was to assess TERT-CLPTM1L single-nucleotide polymorphisms (SNPs) (rs402710 C/T in the CLPTM1L gene; rs2736100 A/C and rs2736098 G/A in the TERT gene) as risk factors for development of oral squamous cell carcinoma (OSCC), and to investigate the relationship between the analyzed polymorphisms, relative telomere length (RTL), telomerase expression and clinicopathologic characteristics of OSCC in a Serbian population. Paraffin-embedded tumor samples and buccal swabs from cancer-free controls were genotyped using PCR-RFLP, while tumor RTL values and telomerase expression were estimated by real-time PCR and immunohistochemistry, respectively. CLPTM1L rs402710 and TERT rs2736100 polymorphisms were associated with a significantly increased risk of OSCC, and TERT rs2736098 with a significantly decreased risk. No significant association was found between TERT-CLPTM1L polymorphisms, tumor RTL values, telomerase expression, and clinicopathologic features, although a trend towards longer telomeres was evident in telomerase-positive samples and less advanced tumors. Kaplan-Meier survival analysis showed that patients with longer telomeres in their tumors had significantly better overall survival than patients with shorter telomeres. Our research seems to provide strong evidence for an association between CLPTMIL rs402710C/T and TERT rs2736100A/C SNPs and the risk of OSSC, and suggests that higher tumor RTL values and positive hTERT expression may be applicable as early prognostic markers.en
dc.publisherNihon Univ, School Dentistry, Toyko
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS//
dc.rightsopenAccess
dc.sourceJournal of Oral Science
dc.subjectOSCCen
dc.subjectTERT-CLPTM1Len
dc.subjecttelomere lengthen
dc.subjecttelomeraseen
dc.titleThe role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinomaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAнтуновић, Марија; Чаркић, Јелена; Поповић, Бранка; Радојевић-Шкодрић, Сања; Милашин, Јелена; Брајовић, Гаврило; Николић, Нађа; Кузмановић-Пфићер, Јована;
dc.citation.volume58
dc.citation.issue4
dc.citation.spage449
dc.citation.epage458
dc.citation.other58(4): 449-458
dc.citation.rankM23
dc.identifier.wos000390087600001
dc.identifier.doi10.2334/josnusd.16-0108
dc.identifier.pmid28025427
dc.identifier.scopus2-s2.0-85007377411
dc.identifier.fulltexthttps://smile.stomf.bg.ac.rs/bitstream/id/729/2110.pdf
dc.type.versionpublishedVersion


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