Association between dementia and tooth loss has been shown although the nature of that association is not clear. It has also been shown that risk of dementia was increased in apolipoprotein E4 allele carriers. The objective of this study was to determine the frequency of APOE alleles and their association with the dental status in elderly demented patients. Dental status of 67 patients with dementia was recorded. DNA was isolated from buccal swabs and genotyping was done by PCR-RFLP. The majority of participants had E3/E4 genotype (55.2%) and these heterozygotes were significantly more frequent than any other genotype (p lt 0.001). There was no significant association between dental status and genotype. However, partial edentulousness with very few teeth in both jaws (1-9 teeth) was significantly more frequent among demented patients with E3/E4 genotype (p=0.021). Patients with Alzheimer disease most frequently had E3/E4 genotype and had very few or no teeth.
Keywords:
Alzheimer disease / apolipoprotein E polymorphism / teeth number / dental status
TY - JOUR
AU - Popovac, Aleksandra
AU - Stančić, Ivica
AU - Despotović, Nebojša
AU - Nikolić, Nadja
AU - Stefanova, Elka
AU - Milašin, Jelena
PY - 2016
UR - https://smile.stomf.bg.ac.rs/handle/123456789/2116
AB - Association between dementia and tooth loss has been shown although the nature of that association is not clear. It has also been shown that risk of dementia was increased in apolipoprotein E4 allele carriers. The objective of this study was to determine the frequency of APOE alleles and their association with the dental status in elderly demented patients. Dental status of 67 patients with dementia was recorded. DNA was isolated from buccal swabs and genotyping was done by PCR-RFLP. The majority of participants had E3/E4 genotype (55.2%) and these heterozygotes were significantly more frequent than any other genotype (p lt 0.001). There was no significant association between dental status and genotype. However, partial edentulousness with very few teeth in both jaws (1-9 teeth) was significantly more frequent among demented patients with E3/E4 genotype (p=0.021). Patients with Alzheimer disease most frequently had E3/E4 genotype and had very few or no teeth.
PB - Društvo genetičara Srbije, Beograd
T2 - Genetika - Belgrade
T1 - Difference in apolipoprotein e genotype distribution between dentate and edentulous elderly patients with Alzheimer disease
VL - 48
IS - 2
SP - 699
EP - 706
DO - 10.2298/GENSR1602699P
ER -
@article{
author = "Popovac, Aleksandra and Stančić, Ivica and Despotović, Nebojša and Nikolić, Nadja and Stefanova, Elka and Milašin, Jelena",
year = "2016",
abstract = "Association between dementia and tooth loss has been shown although the nature of that association is not clear. It has also been shown that risk of dementia was increased in apolipoprotein E4 allele carriers. The objective of this study was to determine the frequency of APOE alleles and their association with the dental status in elderly demented patients. Dental status of 67 patients with dementia was recorded. DNA was isolated from buccal swabs and genotyping was done by PCR-RFLP. The majority of participants had E3/E4 genotype (55.2%) and these heterozygotes were significantly more frequent than any other genotype (p lt 0.001). There was no significant association between dental status and genotype. However, partial edentulousness with very few teeth in both jaws (1-9 teeth) was significantly more frequent among demented patients with E3/E4 genotype (p=0.021). Patients with Alzheimer disease most frequently had E3/E4 genotype and had very few or no teeth.",
publisher = "Društvo genetičara Srbije, Beograd",
journal = "Genetika - Belgrade",
title = "Difference in apolipoprotein e genotype distribution between dentate and edentulous elderly patients with Alzheimer disease",
volume = "48",
number = "2",
pages = "699-706",
doi = "10.2298/GENSR1602699P"
}
Popovac, A., Stančić, I., Despotović, N., Nikolić, N., Stefanova, E.,& Milašin, J.. (2016). Difference in apolipoprotein e genotype distribution between dentate and edentulous elderly patients with Alzheimer disease. in Genetika - Belgrade
Društvo genetičara Srbije, Beograd., 48(2), 699-706.
https://doi.org/10.2298/GENSR1602699P
Popovac A, Stančić I, Despotović N, Nikolić N, Stefanova E, Milašin J. Difference in apolipoprotein e genotype distribution between dentate and edentulous elderly patients with Alzheimer disease. in Genetika - Belgrade. 2016;48(2):699-706.
doi:10.2298/GENSR1602699P .
Popovac, Aleksandra, Stančić, Ivica, Despotović, Nebojša, Nikolić, Nadja, Stefanova, Elka, Milašin, Jelena, "Difference in apolipoprotein e genotype distribution between dentate and edentulous elderly patients with Alzheimer disease" in Genetika - Belgrade, 48, no. 2 (2016):699-706,
https://doi.org/10.2298/GENSR1602699P . .
