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dc.creatorPetrović, Nina
dc.creatorDavidović, Radoslav
dc.creatorJovanović-Cupić, Snezana
dc.creatorKrajnović, Milena
dc.creatorLukić, Silvana
dc.creatorPetrović, Milan
dc.creatorRoganović, Jelena
dc.date.accessioned2020-07-02T13:05:04Z
dc.date.available2020-07-02T13:05:04Z
dc.date.issued2016
dc.identifier.issn1177-1062
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/2120
dc.description.abstractBreast cancer (BC) is a heterogeneous group of diseases that still represents a major cause of death in the female population. MicroRNAs (miRNAs, miRs), such as miR-221 and miR-222, have been shown to be involved in BC pathology by acting via its target genes such as tissue inhibitor of metalloproteinase 3 (TIMP3). The main goals of this study were to find differences in miR-221/222 levels of expression in BC groups based on invasiveness, and to investigate the association with estrogen receptor (ER), TIMP3 messenger RNA (mRNA) levels, and clinicopathological characteristics of patients and tumors. In this study, we measured levels of miR-221/222 in 63 breast tissue samples by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) using TaqMan(A (R)) technology and immunohistochemistry. miR-221/222 levels varied significantly across groups based on invasiveness (P lt 0.001). In in situ tumors, miR-221 and miR-222 were negatively associated with ER (P = 0.001, r = -0.714, and P = 0.013, r = -0.585, respectively). In invasive breast carcinomas associated with non-invasive tumors, miR-222 was inversely associated with ER (P = 0.039, r = -0.620). Pure invasive BCs showed a positive correlation of miR-221 and miR-222 with TIMP3 mRNA levels (P = 0.008, r = 0.508, and P = 0.010, r = 0.497, respectively). An increase in miR-221/222 might be an important event for in situ carcinoma formation, and miR-221/222 may be important molecules that highlight potential differences between invasive breast carcinomas associated with non-invasive and pure invasive BCs.en
dc.publisherAdis Int Ltd, Northcote
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173049/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175021/RS//
dc.rightsrestrictedAccess
dc.sourceMolecular Diagnosis & Therapy
dc.titleChanges in miR-221/222 Levels in Invasive and In Situ Carcinomas of the Breast: Differences in Association with Estrogen Receptor and TIMP3 Expression Levelsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПетровић, Нина; Рогановић, Јелена; Петровић, Милан; Лукић, Силвана; Јовановић-Цупић, Снезана; Давидовић, Радослав; Крајновић, Милена;
dc.citation.volume20
dc.citation.issue6
dc.citation.spage603
dc.citation.epage615
dc.citation.other20(6): 603-615
dc.citation.rankM23
dc.identifier.wos000388172700009
dc.identifier.doi10.1007/s40291-016-0230-3
dc.identifier.pmid27488105
dc.identifier.scopus2-s2.0-84982793306
dc.identifier.rcubconv_3409
dc.type.versionpublishedVersion


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