Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain
Samo za registrovane korisnike
2016
Autori
Mladenović, IrenaSupić, Gordana
Kozomara, Ružica
Dodić, Slobodan
Ivković, Nedeljka
Milićević, Bojana
Simić, Ivana
Magić, Zvonko
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Aims: To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, and postoperative pain. Methods: A total of 90 patients with a diagnosis of painful TMD and 92 matched controls were investigated for the presence of TMD, TMD pain, and psychosocial variables by the Research Diagnostic Criteria for TMD. In a prospective cohort study of 40 subjects who underwent extraction of at least one fully impacted mandibular third molar, subjects had 6 months post-surgery follow-up of postoperative pain. DNA extracted from peripheral blood was genotyped for three COMT polymorphisms (rs4680, rs6269, and rs165774) by real-time TaqMan method. The association between COMT polymorphisms and clinical variables was determined by calculating odds ratios (OR) and their 95% confidence intervals (CO. Results: Homozygous AA genotype and heterozygous variant A allele carriers (genotype AG/AA) f...or rs165774 polymorphism were associated with increased risk of TMD compared to wild type (wt) GG genotype (OR = 9.448, P =.006; OR = 2.088, P =.017, respectively). In addition, AA genotype was associated with increased risk of arthralgia (OR = 4.448, P =.011), myofascial pain (OR = 3.543, P =.035), and chronic TMD pain (OR = 6.173, P =.006), compared to wt genotype. AA genotype for rs6269 polymorphism was related to less postoperative chronic TMD pain (P =.025) and lower postoperative acute pain at the extraction site (P =.030). No associations with depression and somatization were observed. Conclusion: AA genotype of rs165774 could be a significant risk factor for the development of TMD and TMD pain, while AA genotype of rs6269 presents less postoperative chronic TMD pain and acute pain at a dental extraction site.
Ključne reči:
COMT / genetic polymorphisms / pain / temporomandibular disorders / third molar surgeryIzvor:
Journal of Oral & Facial Pain & Headache, 2016, 30, 4, 302-310Izdavač:
- Quintessence Publishing Co Inc, Hanover Park
Finansiranje / projekti:
- Ministry of Science and TechnologyMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [19/6-020/961-175/12]
DOI: 10.11607/ofph.1688
ISSN: 2333-0384
PubMed: 27792797
WoS: 000387521700004
Scopus: 2-s2.0-85010699650
Kolekcije
Institucija/grupa
Stomatološki fakultetTY - JOUR AU - Mladenović, Irena AU - Supić, Gordana AU - Kozomara, Ružica AU - Dodić, Slobodan AU - Ivković, Nedeljka AU - Milićević, Bojana AU - Simić, Ivana AU - Magić, Zvonko PY - 2016 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2124 AB - Aims: To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, and postoperative pain. Methods: A total of 90 patients with a diagnosis of painful TMD and 92 matched controls were investigated for the presence of TMD, TMD pain, and psychosocial variables by the Research Diagnostic Criteria for TMD. In a prospective cohort study of 40 subjects who underwent extraction of at least one fully impacted mandibular third molar, subjects had 6 months post-surgery follow-up of postoperative pain. DNA extracted from peripheral blood was genotyped for three COMT polymorphisms (rs4680, rs6269, and rs165774) by real-time TaqMan method. The association between COMT polymorphisms and clinical variables was determined by calculating odds ratios (OR) and their 95% confidence intervals (CO. Results: Homozygous AA genotype and heterozygous variant A allele carriers (genotype AG/AA) for rs165774 polymorphism were associated with increased risk of TMD compared to wild type (wt) GG genotype (OR = 9.448, P =.006; OR = 2.088, P =.017, respectively). In addition, AA genotype was associated with increased risk of arthralgia (OR = 4.448, P =.011), myofascial pain (OR = 3.543, P =.035), and chronic TMD pain (OR = 6.173, P =.006), compared to wt genotype. AA genotype for rs6269 polymorphism was related to less postoperative chronic TMD pain (P =.025) and lower postoperative acute pain at the extraction site (P =.030). No associations with depression and somatization were observed. Conclusion: AA genotype of rs165774 could be a significant risk factor for the development of TMD and TMD pain, while AA genotype of rs6269 presents less postoperative chronic TMD pain and acute pain at a dental extraction site. PB - Quintessence Publishing Co Inc, Hanover Park T2 - Journal of Oral & Facial Pain & Headache T1 - Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain VL - 30 IS - 4 SP - 302 EP - 310 DO - 10.11607/ofph.1688 ER -
@article{ author = "Mladenović, Irena and Supić, Gordana and Kozomara, Ružica and Dodić, Slobodan and Ivković, Nedeljka and Milićević, Bojana and Simić, Ivana and Magić, Zvonko", year = "2016", abstract = "Aims: To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, and postoperative pain. Methods: A total of 90 patients with a diagnosis of painful TMD and 92 matched controls were investigated for the presence of TMD, TMD pain, and psychosocial variables by the Research Diagnostic Criteria for TMD. In a prospective cohort study of 40 subjects who underwent extraction of at least one fully impacted mandibular third molar, subjects had 6 months post-surgery follow-up of postoperative pain. DNA extracted from peripheral blood was genotyped for three COMT polymorphisms (rs4680, rs6269, and rs165774) by real-time TaqMan method. The association between COMT polymorphisms and clinical variables was determined by calculating odds ratios (OR) and their 95% confidence intervals (CO. Results: Homozygous AA genotype and heterozygous variant A allele carriers (genotype AG/AA) for rs165774 polymorphism were associated with increased risk of TMD compared to wild type (wt) GG genotype (OR = 9.448, P =.006; OR = 2.088, P =.017, respectively). In addition, AA genotype was associated with increased risk of arthralgia (OR = 4.448, P =.011), myofascial pain (OR = 3.543, P =.035), and chronic TMD pain (OR = 6.173, P =.006), compared to wt genotype. AA genotype for rs6269 polymorphism was related to less postoperative chronic TMD pain (P =.025) and lower postoperative acute pain at the extraction site (P =.030). No associations with depression and somatization were observed. Conclusion: AA genotype of rs165774 could be a significant risk factor for the development of TMD and TMD pain, while AA genotype of rs6269 presents less postoperative chronic TMD pain and acute pain at a dental extraction site.", publisher = "Quintessence Publishing Co Inc, Hanover Park", journal = "Journal of Oral & Facial Pain & Headache", title = "Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain", volume = "30", number = "4", pages = "302-310", doi = "10.11607/ofph.1688" }
Mladenović, I., Supić, G., Kozomara, R., Dodić, S., Ivković, N., Milićević, B., Simić, I.,& Magić, Z.. (2016). Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain. in Journal of Oral & Facial Pain & Headache Quintessence Publishing Co Inc, Hanover Park., 30(4), 302-310. https://doi.org/10.11607/ofph.1688
Mladenović I, Supić G, Kozomara R, Dodić S, Ivković N, Milićević B, Simić I, Magić Z. Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain. in Journal of Oral & Facial Pain & Headache. 2016;30(4):302-310. doi:10.11607/ofph.1688 .
Mladenović, Irena, Supić, Gordana, Kozomara, Ružica, Dodić, Slobodan, Ivković, Nedeljka, Milićević, Bojana, Simić, Ivana, Magić, Zvonko, "Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain" in Journal of Oral & Facial Pain & Headache, 30, no. 4 (2016):302-310, https://doi.org/10.11607/ofph.1688 . .