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dc.creatorMladenović, Irena
dc.creatorSupić, Gordana
dc.creatorKozomara, Ružica
dc.creatorDodić, Slobodan
dc.creatorIvković, Nedeljka
dc.creatorMilićević, Bojana
dc.creatorSimić, Ivana
dc.creatorMagić, Zvonko
dc.date.accessioned2020-07-02T13:05:19Z
dc.date.available2020-07-02T13:05:19Z
dc.date.issued2016
dc.identifier.issn2333-0384
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/2124
dc.description.abstractAims: To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, and postoperative pain. Methods: A total of 90 patients with a diagnosis of painful TMD and 92 matched controls were investigated for the presence of TMD, TMD pain, and psychosocial variables by the Research Diagnostic Criteria for TMD. In a prospective cohort study of 40 subjects who underwent extraction of at least one fully impacted mandibular third molar, subjects had 6 months post-surgery follow-up of postoperative pain. DNA extracted from peripheral blood was genotyped for three COMT polymorphisms (rs4680, rs6269, and rs165774) by real-time TaqMan method. The association between COMT polymorphisms and clinical variables was determined by calculating odds ratios (OR) and their 95% confidence intervals (CO. Results: Homozygous AA genotype and heterozygous variant A allele carriers (genotype AG/AA) for rs165774 polymorphism were associated with increased risk of TMD compared to wild type (wt) GG genotype (OR = 9.448, P =.006; OR = 2.088, P =.017, respectively). In addition, AA genotype was associated with increased risk of arthralgia (OR = 4.448, P =.011), myofascial pain (OR = 3.543, P =.035), and chronic TMD pain (OR = 6.173, P =.006), compared to wt genotype. AA genotype for rs6269 polymorphism was related to less postoperative chronic TMD pain (P =.025) and lower postoperative acute pain at the extraction site (P =.030). No associations with depression and somatization were observed. Conclusion: AA genotype of rs165774 could be a significant risk factor for the development of TMD and TMD pain, while AA genotype of rs6269 presents less postoperative chronic TMD pain and acute pain at a dental extraction site.en
dc.publisherQuintessence Publishing Co Inc, Hanover Park
dc.relationMinistry of Science and TechnologyMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [19/6-020/961-175/12]
dc.rightsrestrictedAccess
dc.sourceJournal of Oral & Facial Pain & Headache
dc.subjectCOMTen
dc.subjectgenetic polymorphismsen
dc.subjectpainen
dc.subjecttemporomandibular disordersen
dc.subjectthird molar surgeryen
dc.titleGenetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Painen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМагић, Звонко; Додић, Слободан; Козомара, Ружица; Младеновић, Ирена; Ивковић, Недељка; Милићевић, Бојана; Супић, Гордана; Симић, Ивана;
dc.citation.volume30
dc.citation.issue4
dc.citation.spage302
dc.citation.epage310
dc.citation.other30(4): 302-310
dc.citation.rankM21
dc.identifier.wos000387521700004
dc.identifier.doi10.11607/ofph.1688
dc.identifier.pmid27792797
dc.identifier.scopus2-s2.0-85010699650
dc.identifier.rcubconv_3402
dc.type.versionpublishedVersion


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