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dc.creatorStanković, Marija
dc.creatorPantić, Igor
dc.creatorde Luka, Silvio R.
dc.creatorPuškaš, Nela
dc.creatorZaletel, Ivan
dc.creatorMilutinović-Smiljanić, Sanja
dc.creatorPantić, Senka
dc.creatorTrbovich, Alexander M.
dc.date.accessioned2020-07-02T13:05:37Z
dc.date.available2020-07-02T13:05:37Z
dc.date.issued2016
dc.identifier.issn0022-2720
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/2129
dc.description.abstractThe aim of the study was to examine alteration and possible application of fractal dimension, angular second moment, and correlation for quantification of structural changes in acutely inflamed tissue. Acute inflammation was induced by injection of turpentine oil into the right and left hind limb muscles of mice, whereas control animals received intramuscular saline injection. After 12h, animals were anesthetised and treated muscles collected. The tissue was stained by hematoxylin and eosin, digital micrographs produced, enabling determination of fractal dimension of the cells, angular second moment and correlation of studied tissue. Histopathological analysis showed presence of inflammatory infiltrate and tissue damage in inflammatory group, whereas tissue structure in control group was preserved, devoid of inflammatory infiltrate. Fractal dimension of the cells, angular second moment and correlation of treated tissue in inflammatory group decreased in comparison to the control group. In this study, we were first to observe and report that fractal dimension of the cells, angular second moment, and correlation were reduced in acutely inflamed tissue, indicating loss of overall complexity of the cells in the tissue, the tissue uniformity and structure regularity. Fractal dimension, angular second moment and correlation could be useful methods for quantification of structural changes in acute inflammation. Lay Description The aim of this study was to examine alteration, and possible application of mathematical parameters fractal dimension, angular second moment, and correlation for quantification of structural changes in acutely-inflamed tissue. An acute inflammation was induced by injection of turpentine oil into mice muscles, whereas control group received intramuscular injection of saline. After 12 h animals were anesthetized, and treated muscles were collected. The tissue was stained, and photos of the tissue were made. Mathematical parameters, namely fractal dimension, angular second moment, and correlation of the tissue photo, were determined by computer program. Standard histopathological analysis showed that inflammatory infiltrate and tissue damage were present in inflammatory group, whereas tissue structure in control group was preserved, and without inflammatory infiltrate. Fractal dimension of the cells, angular second moment and correlation of the treated tissue in inflammatory group decreased, when compared to control group. In this study we reported, for the first time, that fractal dimension of the cells, angular second moment, and correlation had decreased in acutely-inflamed tissue, indicating loss of overall complexity of cells in tissue, tissue uniformity, and structure regularity. Fractal dimension, angular second moment, and correlation could be useful methods for quantification of structural changes in acute inflammation.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41013/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Microscopy
dc.subjectAcute inflammationen
dc.subjectangular second momenten
dc.subjectcorrelationen
dc.subjectfractal dimensionen
dc.titleQuantification of structural changes in acute inflammation by fractal dimension, angular second moment and correlationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПушкаш, Нела; Милутиновић-Смиљанић, Сања; Залетел, Иван; де Лука, Силвио Р.; Пантић, Игор; Пантић, Сенка; Станковић, Марија; Трбовицх, Aлеxандер М.;
dc.citation.volume261
dc.citation.issue3
dc.citation.spage277
dc.citation.epage284
dc.citation.other261(3): 277-284
dc.citation.rankM22
dc.identifier.wos000371637200008
dc.identifier.doi10.1111/jmi.12330
dc.identifier.pmid26501409
dc.identifier.scopus2-s2.0-84958868443
dc.type.versionpublishedVersion


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