In vitro avarol does affect the growth of Candida sp.
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2016
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] .
Ključne reči:
Marine sponge / Dysidea avara / avarol / oral pathogens / anticandidial activity / Alzheimer's diseaseIzvor:
Natural Product Research, 2016, 30, 17, 1956-1960Izdavač:
- Taylor & Francis Ltd, Abingdon
Finansiranje / projekti:
- Sinteza i biološka ispitivanja novih mimetika ili derivata odabranih citotoksičnih laktona, antitumorskog agensa tiazofurina i prirodnih naftnih kiselina (RS-172006)
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-172053)
DOI: 10.1080/14786419.2015.1091454
ISSN: 1478-6419
PubMed: 26405848
WoS: 000382562400010
Scopus: 2-s2.0-84981285540
Kolekcije
Institucija/grupa
Stomatološki fakultetTY - JOUR AU - Pejin, Boris AU - Ćirić, Ana AU - Marković, Dejan AU - Tommonaro, Giuseppina AU - Soković, Marina PY - 2016 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2131 AB - This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] . PB - Taylor & Francis Ltd, Abingdon T2 - Natural Product Research T1 - In vitro avarol does affect the growth of Candida sp. VL - 30 IS - 17 SP - 1956 EP - 1960 DO - 10.1080/14786419.2015.1091454 ER -
@article{ author = "Pejin, Boris and Ćirić, Ana and Marković, Dejan and Tommonaro, Giuseppina and Soković, Marina", year = "2016", abstract = "This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] .", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Natural Product Research", title = "In vitro avarol does affect the growth of Candida sp.", volume = "30", number = "17", pages = "1956-1960", doi = "10.1080/14786419.2015.1091454" }
Pejin, B., Ćirić, A., Marković, D., Tommonaro, G.,& Soković, M.. (2016). In vitro avarol does affect the growth of Candida sp.. in Natural Product Research Taylor & Francis Ltd, Abingdon., 30(17), 1956-1960. https://doi.org/10.1080/14786419.2015.1091454
Pejin B, Ćirić A, Marković D, Tommonaro G, Soković M. In vitro avarol does affect the growth of Candida sp.. in Natural Product Research. 2016;30(17):1956-1960. doi:10.1080/14786419.2015.1091454 .
Pejin, Boris, Ćirić, Ana, Marković, Dejan, Tommonaro, Giuseppina, Soković, Marina, "In vitro avarol does affect the growth of Candida sp." in Natural Product Research, 30, no. 17 (2016):1956-1960, https://doi.org/10.1080/14786419.2015.1091454 . .