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dc.creatorPerunović, Neda
dc.creatorRakić, Mia
dc.creatorNikolić, Ljubinka
dc.creatorJanković, Saša
dc.creatorAleksić, Zoran
dc.creatorPlećaš, Darko
dc.creatorMadianos, Phoebus N.
dc.creatorČakić, Saša
dc.date.accessioned2020-07-02T13:06:08Z
dc.date.available2020-07-02T13:06:08Z
dc.date.issued2016
dc.identifier.issn0022-3492
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/2137
dc.description.abstractBackground: Periodontitis is considered to be a risk factor for preterm birth. Mechanisms have been proposed for this pathologic relation, but the exact pathologic pattern remains unclear. Therefore, the objective of the present study is to evaluate levels of four major labor triggers, prostaglandin E-2 (PGE(2)), interleukin (IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha, in gingival crevicular fluid (GCF) and serum samples between women with preterm birth (PTB) and full-term birth (FTB) and correlate them with periodontal parameters. Methods: PGE(2), IL-1 beta, IL-6, and TNF-alpha levels were estimated using enzyme-linked immunosorbent assays in GCF and serum samples collected 24 to 48 hours after labor from 120 women (60 FTB, 60 PTB). Results: Women with PTB exhibited significantly more periodontitis, worse periodontal parameters, and increased GCF levels of IL-6 and PGE(2) compared with the FTB group; there were no significant differences in serum levels of measured markers. GCF levels of IL-1 beta, IL-6, and PGE(2) and serum levels of TNF-alpha and PGE(2) were significantly higher in women with periodontitis compared with periodontally healthy women. Serum levels of PGE(2) were positively correlated with probing depth (PD) and clinical attachment level (CAL) as well as with GCF levels of TNF-alpha in women with PTB. Conclusions: Women with PTB demonstrated worse periodontal parameters and significantly increased GCF levels of IL-6 and PGE(2) compared with those with FTB. Based on significant correlations among serum PGE(2) and PD, CAL, and GCF TNF-alpha in PTB, periodontitis may cause an overall increase of labor triggers and hence contribute to preterm labor onset.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41008/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Periodontology
dc.subjectCytokinesen
dc.subjectperiodontal diseasesen
dc.subjectperiodontitisen
dc.subjectpregnancy outcomeen
dc.subjectpremature birthen
dc.subjectprostaglandin E2en
dc.titleThe Association Between Periodontal Inflammation and Labor Triggers (Elevated Cytokine Levels) in Preterm Birth: A Cross-Sectional Studyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНиколић, Љубинка; Перуновић, Неда; Ракић, Миа; Плећаш, Дарко; Мадианос, Пхоебус Н.; Јанковић, Саша; Aлексић, Зоран; Чакић, Саша;
dc.citation.volume87
dc.citation.issue3
dc.citation.spage248
dc.citation.epage256
dc.citation.other87(3): 248-256
dc.citation.rankM21
dc.identifier.wos000371163200008
dc.identifier.doi10.1902/jop.2015.150364
dc.identifier.pmid26447753
dc.identifier.scopus2-s2.0-84964533579
dc.identifier.rcubconv_3340
dc.type.versionpublishedVersion


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