Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression
Authorized Users Only
2016
Authors
Brajić, Ivana
Skodrić, Sanja
Milenković, S.
Tepavčević, Zvezdana
Soldatović, Ivan

Čolić, Snježana
Milašin, Jelena

Andrić, Miroslav

Article (Published version)

Metadata
Show full item recordAbstract
ObjectivesThe aim of this study was to investigate survivin, cyclin D1, and p21hras expression in keratocystic odontogenic tumors before and after decompression, as well as in pericoronal follicles. A potential correlation between the expression levels of these proteins was also investigated. Materials and methodsWe analyzed eighteen keratocystic tumors treated by decompression and subsequent enucleation along with seven pericoronal follicles using immunohistochemistry. ResultsKeratocystic tumor samples, both before and after decompression, were positive for each of the investigated proteins. In pericoronal follicles, survivin exhibited cytoplasmic staining in contrast to nuclear staining in keratocystic tumors. Cyclin D1 expression was negative in pericoronal follicles, and p21hras expression was similar in both groups. Survivin showed significantly higher expression after decompression, while cyclin D1 and p21hras remained unchanged (P=0.039, P=0.255, P=0.913, respectively). There wa...s no correlation between these proteins neither before nor after decompression. ConclusionsWithin the limits of the study, we can conclude that following decompression, keratocystic odontogenic tumors preserve distinct immunohistochemical profiles of cyclin D1 and p21hras expression, despite substantial reduction in size of the lesions. Significant increase of survivin expression after decompression might be attributed to higher level of epithelial proliferation caused by this procedure.
Keywords:
survivin / cyclin D1 / p21hras / keratocystic odontogenic tumor / decompressionSource:
Oral Diseases, 2016, 22, 3, 220-225Publisher:
- Wiley-Blackwell, Hoboken
Funding / projects:
DOI: 10.1111/odi.12414
ISSN: 1354-523X
PubMed: 26662564
WoS: 000372354400010
Scopus: 2-s2.0-84959352731
Collections
Institution/Community
Stomatološki fakultetTY - JOUR AU - Brajić, Ivana AU - Skodrić, Sanja AU - Milenković, S. AU - Tepavčević, Zvezdana AU - Soldatović, Ivan AU - Čolić, Snježana AU - Milašin, Jelena AU - Andrić, Miroslav PY - 2016 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2140 AB - ObjectivesThe aim of this study was to investigate survivin, cyclin D1, and p21hras expression in keratocystic odontogenic tumors before and after decompression, as well as in pericoronal follicles. A potential correlation between the expression levels of these proteins was also investigated. Materials and methodsWe analyzed eighteen keratocystic tumors treated by decompression and subsequent enucleation along with seven pericoronal follicles using immunohistochemistry. ResultsKeratocystic tumor samples, both before and after decompression, were positive for each of the investigated proteins. In pericoronal follicles, survivin exhibited cytoplasmic staining in contrast to nuclear staining in keratocystic tumors. Cyclin D1 expression was negative in pericoronal follicles, and p21hras expression was similar in both groups. Survivin showed significantly higher expression after decompression, while cyclin D1 and p21hras remained unchanged (P=0.039, P=0.255, P=0.913, respectively). There was no correlation between these proteins neither before nor after decompression. ConclusionsWithin the limits of the study, we can conclude that following decompression, keratocystic odontogenic tumors preserve distinct immunohistochemical profiles of cyclin D1 and p21hras expression, despite substantial reduction in size of the lesions. Significant increase of survivin expression after decompression might be attributed to higher level of epithelial proliferation caused by this procedure. PB - Wiley-Blackwell, Hoboken T2 - Oral Diseases T1 - Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression VL - 22 IS - 3 SP - 220 EP - 225 DO - 10.1111/odi.12414 ER -
@article{ author = "Brajić, Ivana and Skodrić, Sanja and Milenković, S. and Tepavčević, Zvezdana and Soldatović, Ivan and Čolić, Snježana and Milašin, Jelena and Andrić, Miroslav", year = "2016", abstract = "ObjectivesThe aim of this study was to investigate survivin, cyclin D1, and p21hras expression in keratocystic odontogenic tumors before and after decompression, as well as in pericoronal follicles. A potential correlation between the expression levels of these proteins was also investigated. Materials and methodsWe analyzed eighteen keratocystic tumors treated by decompression and subsequent enucleation along with seven pericoronal follicles using immunohistochemistry. ResultsKeratocystic tumor samples, both before and after decompression, were positive for each of the investigated proteins. In pericoronal follicles, survivin exhibited cytoplasmic staining in contrast to nuclear staining in keratocystic tumors. Cyclin D1 expression was negative in pericoronal follicles, and p21hras expression was similar in both groups. Survivin showed significantly higher expression after decompression, while cyclin D1 and p21hras remained unchanged (P=0.039, P=0.255, P=0.913, respectively). There was no correlation between these proteins neither before nor after decompression. ConclusionsWithin the limits of the study, we can conclude that following decompression, keratocystic odontogenic tumors preserve distinct immunohistochemical profiles of cyclin D1 and p21hras expression, despite substantial reduction in size of the lesions. Significant increase of survivin expression after decompression might be attributed to higher level of epithelial proliferation caused by this procedure.", publisher = "Wiley-Blackwell, Hoboken", journal = "Oral Diseases", title = "Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression", volume = "22", number = "3", pages = "220-225", doi = "10.1111/odi.12414" }
Brajić, I., Skodrić, S., Milenković, S., Tepavčević, Z., Soldatović, I., Čolić, S., Milašin, J.,& Andrić, M.. (2016). Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression. in Oral Diseases Wiley-Blackwell, Hoboken., 22(3), 220-225. https://doi.org/10.1111/odi.12414
Brajić I, Skodrić S, Milenković S, Tepavčević Z, Soldatović I, Čolić S, Milašin J, Andrić M. Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression. in Oral Diseases. 2016;22(3):220-225. doi:10.1111/odi.12414 .
Brajić, Ivana, Skodrić, Sanja, Milenković, S., Tepavčević, Zvezdana, Soldatović, Ivan, Čolić, Snježana, Milašin, Jelena, Andrić, Miroslav, "Survivin, cyclin D1, and p21hras in keratocystic odontogenic tumors before and after decompression" in Oral Diseases, 22, no. 3 (2016):220-225, https://doi.org/10.1111/odi.12414 . .