In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA

2016
Аутори
Jokanović, Vukoman
Čolović, Božana

Marković, Dejan

Petrović, Milan

Jokanović, Milan
Milosavljević, Petar
Sopta, Jelena
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A synthetic bone substitute based on calcium hydroxyapatite (CHA) and poly(lactic-co-glycolic) acid (PLGA), described in this paper, was synthesized to fulfill specific requirements like biodegradability, satisfying mechanical properties, optimal porosity and nanotopology, osteoinductive and osteoconductive properties, and so forth. Structural and morphological properties of the new scaffold were analyzed by micro computed tomography and scanning electron microscopy, while its physicochemical properties were investigated by X-ray diffraction and infrared spectroscopy. In vivo biological investigations of the synthesized scaffold were conducted over the cutaneous irritation and biofunctionality assays on rabbits and the test of acute systemic toxicity on mice. The results showed that the scaffold is not irritant and that it does not exhibit any symptoms of acute toxicity. Biofunctionality assays which include evaluation of the presence of various cells of immune response, the presence o...f neoangiogenesis, percentage of mineralization of newly formed bone, and fibroplasia in the tissue indicated that the new scaffold is suitable for the application in maxillofacial and dental surgery as a bone substitute. Also, it showed significant advantages over commercial product Geistlich Bio-Oss(R) from the aspect of some parameters of immunological response.
Извор:
Journal of Nanomaterials, 2016, 2016Издавач:
- Hindawi Ltd, London
Финансирање / пројекти:
- Хемијско и структурно дизајнирање наноматеријала за примену у медицини и инжењерству ткива (RS-172026)
DOI: 10.1155/2016/3948768
ISSN: 1687-4110
WoS: 000374899500001
Scopus: 2-s2.0-84969790689
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Jokanović, Vukoman AU - Čolović, Božana AU - Marković, Dejan AU - Petrović, Milan AU - Jokanović, Milan AU - Milosavljević, Petar AU - Sopta, Jelena PY - 2016 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2168 AB - A synthetic bone substitute based on calcium hydroxyapatite (CHA) and poly(lactic-co-glycolic) acid (PLGA), described in this paper, was synthesized to fulfill specific requirements like biodegradability, satisfying mechanical properties, optimal porosity and nanotopology, osteoinductive and osteoconductive properties, and so forth. Structural and morphological properties of the new scaffold were analyzed by micro computed tomography and scanning electron microscopy, while its physicochemical properties were investigated by X-ray diffraction and infrared spectroscopy. In vivo biological investigations of the synthesized scaffold were conducted over the cutaneous irritation and biofunctionality assays on rabbits and the test of acute systemic toxicity on mice. The results showed that the scaffold is not irritant and that it does not exhibit any symptoms of acute toxicity. Biofunctionality assays which include evaluation of the presence of various cells of immune response, the presence of neoangiogenesis, percentage of mineralization of newly formed bone, and fibroplasia in the tissue indicated that the new scaffold is suitable for the application in maxillofacial and dental surgery as a bone substitute. Also, it showed significant advantages over commercial product Geistlich Bio-Oss(R) from the aspect of some parameters of immunological response. PB - Hindawi Ltd, London T2 - Journal of Nanomaterials T1 - In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA VL - 2016 DO - 10.1155/2016/3948768 ER -
@article{ author = "Jokanović, Vukoman and Čolović, Božana and Marković, Dejan and Petrović, Milan and Jokanović, Milan and Milosavljević, Petar and Sopta, Jelena", year = "2016", abstract = "A synthetic bone substitute based on calcium hydroxyapatite (CHA) and poly(lactic-co-glycolic) acid (PLGA), described in this paper, was synthesized to fulfill specific requirements like biodegradability, satisfying mechanical properties, optimal porosity and nanotopology, osteoinductive and osteoconductive properties, and so forth. Structural and morphological properties of the new scaffold were analyzed by micro computed tomography and scanning electron microscopy, while its physicochemical properties were investigated by X-ray diffraction and infrared spectroscopy. In vivo biological investigations of the synthesized scaffold were conducted over the cutaneous irritation and biofunctionality assays on rabbits and the test of acute systemic toxicity on mice. The results showed that the scaffold is not irritant and that it does not exhibit any symptoms of acute toxicity. Biofunctionality assays which include evaluation of the presence of various cells of immune response, the presence of neoangiogenesis, percentage of mineralization of newly formed bone, and fibroplasia in the tissue indicated that the new scaffold is suitable for the application in maxillofacial and dental surgery as a bone substitute. Also, it showed significant advantages over commercial product Geistlich Bio-Oss(R) from the aspect of some parameters of immunological response.", publisher = "Hindawi Ltd, London", journal = "Journal of Nanomaterials", title = "In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA", volume = "2016", doi = "10.1155/2016/3948768" }
Jokanović, V., Čolović, B., Marković, D., Petrović, M., Jokanović, M., Milosavljević, P.,& Sopta, J.. (2016). In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA. in Journal of Nanomaterials Hindawi Ltd, London., 2016. https://doi.org/10.1155/2016/3948768
Jokanović V, Čolović B, Marković D, Petrović M, Jokanović M, Milosavljević P, Sopta J. In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA. in Journal of Nanomaterials. 2016;2016. doi:10.1155/2016/3948768 .
Jokanović, Vukoman, Čolović, Božana, Marković, Dejan, Petrović, Milan, Jokanović, Milan, Milosavljević, Petar, Sopta, Jelena, "In Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGA" in Journal of Nanomaterials, 2016 (2016), https://doi.org/10.1155/2016/3948768 . .