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dc.creatorRadunović, Milena
dc.creatorNikolić, Nadja
dc.creatorMilenković, Sanja
dc.creatorTomanović, Nada
dc.creatorBoričić, Ivan
dc.creatorDimitrijević, Milovan
dc.creatorNovaković, Ivana
dc.creatorBasta-Jovanović, Gordana
dc.date.accessioned2020-07-02T13:08:42Z
dc.date.available2020-07-02T13:08:42Z
dc.date.issued2016
dc.identifier.issn1107-0625
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/2178
dc.description.abstractPurpose: Matrix metalloproteinases (MMPs) are a family of endopeptidases that may play an important role in the development of salivary gland cancer (SGC). MMP-2 and MMP-9, members of the gelatinase protein family, are capable of degrading type IV collagen of basement membranes, and their overexpression is often associated with tumor aggressiveness and poor prognosis. The aim of this study was to establish the role of single nucleotide polymorphisms (SNPs) in MMP-2 and MMP-9 genes as putative susceptibility factors for the development of SGC. Methods: The MMP-2 -1306 C>T, MMP-2 -1575 G>A and MMP-9 -1562 C>T polymorphisms were analyzed in 93 SGC cases and 100 controls using PCR-RFLP. Results: The T allele for the MMP-2-1306 C>T polymorphism exhibited its effect in heterozygous carriers, increasing the risk for SGC (odds ratio/OR 1.98, 95% CI 1.07-3.65, p=0.03). According to the dominant model, CT+TT genotypes had a 2-fold increased risk of developing SGCs (p=0.02).When the dominant model was applied for the MMP2 -1575 G>A, individuals with GA+AA genotypes exhibited a 1.77-fold increase in cancer risk, but with borderline significance (p=0.049). Heterozygous carriers of the variant T allele for the MMP-9 -1562 C>T polymorphism had roughly a 2-fold increase in susceptibility for SGC compared to wild type homozygotes (CC) (p=0.02). Conclusion: Our findings suggest MMP-2-1306 C>T and MMP-9-1562 C>T polymorphisms genotypes seem to influence the development of SGCs, whereas MMP-2 -1575 G>A seems to be of a minor importance.en
dc.publisherBalkan Union of Oncology (B.U.ON.)
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41027/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of BUON
dc.subjectmatrix metalloproteinasesen
dc.subjectPCR-RFLPen
dc.subjectpolymorphismen
dc.subjectsalivary gland canceren
dc.titleThe MMP-2 and MMP-9 promoter polymorphisms and susceptibility to salivary gland canceren
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРадуновић, Милена; Новаковић, Ивана; Николић, Нађа; Баста-Јовановић, Гордана; Димитријевић, Милован; Боричић, Иван; Томановић, Нада; Миленковић, Сања;
dc.citation.volume21
dc.citation.issue3
dc.citation.spage597
dc.citation.epage602
dc.citation.other21(3): 597-602
dc.citation.rankM23
dc.identifier.wos000378978900011
dc.identifier.pmid27569079
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_smile_2178
dc.type.versionpublishedVersion


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