TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development
Нема приказа
Аутори
Ilić, Branislav![](/themes/MirageSMILE/images/orcid.png)
Nikolić, Nadja
![](/themes/MirageSMILE/images/orcid.png)
Andrić, Miroslav
![](/themes/MirageSMILE/images/orcid.png)
Jelovac, Drago
![](/themes/MirageSMILE/images/orcid.png)
Miličić, Biljana
![](/themes/MirageSMILE/images/orcid.png)
Jozić, Tanja
Krstić, Slobodan
Milašin, Jelena
![](/themes/MirageSMILE/images/orcid.png)
Чланак у часопису (Објављена верзија)
![](/themes/MirageSMILE//images/creativecommons/arr.png)
Метаподаци
Приказ свих података о документуАпстракт
BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-alpha (TNF-alpha) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-alpha (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis. RESULTS: A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P lt 0.05). Carriers of the TNF-alpha A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98-16.56, P lt 0.0001), while carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR= 3.65, CI: 1.60-...8.40, P = 0.001). CONCLUSIONS: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population.
Кључне речи:
odontogenic tumors / risk factors / single nucleotide polymorphisms / TNFR1 / tumor necrosis factor-alphaИзвор:
Journal of Oral Pathology & Medicine, 2017, 46, 4, 292-296Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- Генетичка контрола и молекуларни механизми у малигним, инфламаторним и развојним патологијама орофацијалне регије (RS-MESTD-Basic Research (BR or ON)-175075)
DOI: 10.1111/jop.12564
ISSN: 0904-2512
PubMed: 28199753
WoS: 000400193100008
Scopus: 2-s2.0-85014576383
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Ilić, Branislav AU - Nikolić, Nadja AU - Andrić, Miroslav AU - Jelovac, Drago AU - Miličić, Biljana AU - Jozić, Tanja AU - Krstić, Slobodan AU - Milašin, Jelena PY - 2017 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2190 AB - BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-alpha (TNF-alpha) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-alpha (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis. RESULTS: A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P lt 0.05). Carriers of the TNF-alpha A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98-16.56, P lt 0.0001), while carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR= 3.65, CI: 1.60-8.40, P = 0.001). CONCLUSIONS: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population. PB - Wiley, Hoboken T2 - Journal of Oral Pathology & Medicine T1 - TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development VL - 46 IS - 4 SP - 292 EP - 296 DO - 10.1111/jop.12564 ER -
@article{ author = "Ilić, Branislav and Nikolić, Nadja and Andrić, Miroslav and Jelovac, Drago and Miličić, Biljana and Jozić, Tanja and Krstić, Slobodan and Milašin, Jelena", year = "2017", abstract = "BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-alpha (TNF-alpha) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-alpha (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis. RESULTS: A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P lt 0.05). Carriers of the TNF-alpha A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98-16.56, P lt 0.0001), while carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR= 3.65, CI: 1.60-8.40, P = 0.001). CONCLUSIONS: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population.", publisher = "Wiley, Hoboken", journal = "Journal of Oral Pathology & Medicine", title = "TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development", volume = "46", number = "4", pages = "292-296", doi = "10.1111/jop.12564" }
Ilić, B., Nikolić, N., Andrić, M., Jelovac, D., Miličić, B., Jozić, T., Krstić, S.,& Milašin, J.. (2017). TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development. in Journal of Oral Pathology & Medicine Wiley, Hoboken., 46(4), 292-296. https://doi.org/10.1111/jop.12564
Ilić B, Nikolić N, Andrić M, Jelovac D, Miličić B, Jozić T, Krstić S, Milašin J. TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development. in Journal of Oral Pathology & Medicine. 2017;46(4):292-296. doi:10.1111/jop.12564 .
Ilić, Branislav, Nikolić, Nadja, Andrić, Miroslav, Jelovac, Drago, Miličić, Biljana, Jozić, Tanja, Krstić, Slobodan, Milašin, Jelena, "TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development" in Journal of Oral Pathology & Medicine, 46, no. 4 (2017):292-296, https://doi.org/10.1111/jop.12564 . .