TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development
Nema prikaza
Autori
Ilić, BranislavNikolić, Nadja
Andrić, Miroslav
Jelovac, Drago
Miličić, Biljana
Jozić, Tanja
Krstić, Slobodan
Milašin, Jelena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-alpha (TNF-alpha) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-alpha (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis. RESULTS: A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P lt 0.05). Carriers of the TNF-alpha A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98-16.56, P lt 0.0001), while carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR= 3.65, CI: 1.60-...8.40, P = 0.001). CONCLUSIONS: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population.
Ključne reči:
odontogenic tumors / risk factors / single nucleotide polymorphisms / TNFR1 / tumor necrosis factor-alphaIzvor:
Journal of Oral Pathology & Medicine, 2017, 46, 4, 292-296Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
- Genetička kontrola i molekularni mehanizmi u malignim, inflamatornim i razvojnim patologijama orofacijalne regije (RS-MESTD-Basic Research (BR or ON)-175075)
DOI: 10.1111/jop.12564
ISSN: 0904-2512
PubMed: 28199753
WoS: 000400193100008
Scopus: 2-s2.0-85014576383
Kolekcije
Institucija/grupa
Stomatološki fakultetTY - JOUR AU - Ilić, Branislav AU - Nikolić, Nadja AU - Andrić, Miroslav AU - Jelovac, Drago AU - Miličić, Biljana AU - Jozić, Tanja AU - Krstić, Slobodan AU - Milašin, Jelena PY - 2017 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2190 AB - BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-alpha (TNF-alpha) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-alpha (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis. RESULTS: A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P lt 0.05). Carriers of the TNF-alpha A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98-16.56, P lt 0.0001), while carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR= 3.65, CI: 1.60-8.40, P = 0.001). CONCLUSIONS: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population. PB - Wiley, Hoboken T2 - Journal of Oral Pathology & Medicine T1 - TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development VL - 46 IS - 4 SP - 292 EP - 296 DO - 10.1111/jop.12564 ER -
@article{ author = "Ilić, Branislav and Nikolić, Nadja and Andrić, Miroslav and Jelovac, Drago and Miličić, Biljana and Jozić, Tanja and Krstić, Slobodan and Milašin, Jelena", year = "2017", abstract = "BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-alpha (TNF-alpha) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-alpha (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis. RESULTS: A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P lt 0.05). Carriers of the TNF-alpha A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98-16.56, P lt 0.0001), while carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR= 3.65, CI: 1.60-8.40, P = 0.001). CONCLUSIONS: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population.", publisher = "Wiley, Hoboken", journal = "Journal of Oral Pathology & Medicine", title = "TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development", volume = "46", number = "4", pages = "292-296", doi = "10.1111/jop.12564" }
Ilić, B., Nikolić, N., Andrić, M., Jelovac, D., Miličić, B., Jozić, T., Krstić, S.,& Milašin, J.. (2017). TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development. in Journal of Oral Pathology & Medicine Wiley, Hoboken., 46(4), 292-296. https://doi.org/10.1111/jop.12564
Ilić B, Nikolić N, Andrić M, Jelovac D, Miličić B, Jozić T, Krstić S, Milašin J. TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development. in Journal of Oral Pathology & Medicine. 2017;46(4):292-296. doi:10.1111/jop.12564 .
Ilić, Branislav, Nikolić, Nadja, Andrić, Miroslav, Jelovac, Drago, Miličić, Biljana, Jozić, Tanja, Krstić, Slobodan, Milašin, Jelena, "TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development" in Journal of Oral Pathology & Medicine, 46, no. 4 (2017):292-296, https://doi.org/10.1111/jop.12564 . .