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TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development
dc.creator | Ilić, Branislav | |
dc.creator | Nikolić, Nadja | |
dc.creator | Andrić, Miroslav | |
dc.creator | Jelovac, Drago | |
dc.creator | Miličić, Biljana | |
dc.creator | Jozić, Tanja | |
dc.creator | Krstić, Slobodan | |
dc.creator | Milašin, Jelena | |
dc.date.accessioned | 2020-07-02T13:09:27Z | |
dc.date.available | 2020-07-02T13:09:27Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0904-2512 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/2190 | |
dc.description.abstract | BACKGROUND: Polymorphisms in genes encoding tumor necrosis factor-alpha (TNF-alpha) and its receptor TNF-R1 have been shown to affect one person's susceptibility to develop certain neoplastic diseases. The aim of the present association study was to investigate whether single nucleotide polymorphisms (SNPs) in TNF-alpha (-308G>A) and TNF-R1 (36A>G) genes modulate the susceptibility for keratocystic odontogenic tumors (KCOTs) development in Serbian patients. METHODS: Genotyping was performed in 60 KCOT patients and 125 healthy individuals, using polymerase chain reaction/restriction fragment length polymorphism analysis. RESULTS: A significant difference in genotype and allele frequencies was found between patients and controls for both SNPs (P lt 0.05). Carriers of the TNF-alpha A variant had an eightfold increase of KCOT risk (OR = 8.12, 95% CI = 3.98-16.56, P lt 0.0001), while carriers of the TNF-R1 G variant had approximately a fourfold increase of KCOT risk (OR= 3.65, CI: 1.60-8.40, P = 0.001). CONCLUSIONS: Our findings suggest that the two polymorphisms are strong risk factors for KCOT development in Serbian population. | en |
dc.publisher | Wiley, Hoboken | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Oral Pathology & Medicine | |
dc.subject | odontogenic tumors | en |
dc.subject | risk factors | en |
dc.subject | single nucleotide polymorphisms | en |
dc.subject | TNFR1 | en |
dc.subject | tumor necrosis factor-alpha | en |
dc.title | TNF-alpha (-308G > A) and TNF-R1 (36A > G) single nucleotide polymorphisms are strong risk factors for odontogenic keratocystic tumor development | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Илић, Бранислав; Николић, Нађа; Миличић, Биљана; Јеловац, Драго; Милашин, Јелена; Aндрић, Мирослав; Јозић, Тања; Крстић, Слободан; | |
dc.citation.volume | 46 | |
dc.citation.issue | 4 | |
dc.citation.spage | 292 | |
dc.citation.epage | 296 | |
dc.citation.other | 46(4): 292-296 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000400193100008 | |
dc.identifier.doi | 10.1111/jop.12564 | |
dc.identifier.pmid | 28199753 | |
dc.identifier.scopus | 2-s2.0-85014576383 | |
dc.type.version | publishedVersion |
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