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Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma
dc.creator | Latić, Dragana | |
dc.creator | Radojević-Škodrić, Sanja | |
dc.creator | Nikolić, Srđan | |
dc.creator | Prvanović, Mirjana | |
dc.creator | Lazić, Miodrag | |
dc.creator | Džamić, Zoran | |
dc.creator | Bogdanović, Ljiljana | |
dc.creator | Radunović, Milena | |
dc.creator | Vuković, Marina | |
dc.date.accessioned | 2020-07-02T13:10:28Z | |
dc.date.available | 2020-07-02T13:10:28Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1107-0625 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/2206 | |
dc.description.abstract | Purpose: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. Methods: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed. Results: The highest median value for cyclin A (40%; range 0-70)) and for p16 (57.5%; range 35-80) were found in the papillary histological subtype. Survival analysis showed that in the group of patients that had died before September 2015, the median value for cyclin A was 20% (range 0-60), which was significantly higher than 5% (range 0-70), found in the group of patients that survived (p=0.019). Conclusions: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker. | en |
dc.publisher | Balkan Union of Oncology (B.U.ON.) | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175059/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of BUON | |
dc.subject | cyclin A | en |
dc.subject | immunohistochemistry | en |
dc.subject | p16 | en |
dc.subject | renal cell carcinoma | en |
dc.title | Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Богдановић, Љиљана; Радојевић-Шкодрић, Сања; Николић, Срђан; Првановић, Мирјана; Джамић, Зоран; Вуковић, Марина; Латић, Драгана; Радуновић, Милена; Лазић, Миодраг; | |
dc.citation.volume | 22 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1322 | |
dc.citation.epage | 1327 | |
dc.citation.other | 22(5): 1322-1327 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000417149800033 | |
dc.identifier.pmid | 29135120 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_smile_2206 | |
dc.type.version | publishedVersion |