Приказ основних података о документу

dc.creatorNikolić, Miloš
dc.creatorJovanović, Katarina K.
dc.creatorMarković, Tatjana
dc.creatorMarković, Dejan
dc.creatorGligorijević, Nevenka
dc.creatorRadulović, Siniša
dc.creatorKostić, Marina
dc.creatorGlamočlija, Jasmina
dc.creatorSoković, Marina
dc.date.accessioned2020-07-02T13:11:46Z
dc.date.available2020-07-02T13:11:46Z
dc.date.issued2017
dc.identifier.issn0022-3573
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/2227
dc.description.abstractObjectives The chemical composition, antimicrobial and synergistic effect, and cytotoxic activity of Citrus limon (lemon), Piper nigrum (green pepper) and Melaleuca alternifoila (tea tree) essential oils (EOs) were investigated. Methods Chemical analyses of essential oils were tested by GC-FID and GC-MS spectroscopy. The antimicrobial activity assay was conducted using microdilution method against several oral bacteria and Candida spp. originating from the humans with oral disorders. The synergistic antimicrobial activity was evaluated using checkerboard method. The cytotoxicity evaluation of EOs was assessed using MTT test. Key findings Limonene (37.5%) and beta-pinene (17.9%) were the major compounds in C. limon oil, -pinene (34.4%), delta-3-carene (19.7%), limonene (18.7%) and alpha-pinene (10.4%) in P. nigrum oil and terpinen-4-ol (38.6%) and gamma-terpinene (21.7%) in M. alternifolia oil. The broad-spectrum antimicrobial activity was achieved by tested three EOs, with C. limon oil being the strongest against bacteria and M. alternifolia oil strongest against fungi. The EOs demonstrated synergism; their combined application revealed an increase in antimicrobial activity. All tested essential oils showed lower cytotoxic activity in comparison with the positive control, and the obtained results confirmed a dose-dependent activity. Conclusions The results of this study encourage use of tested EOs in development of a novel agent intended for prevention or therapy of corresponding oral disorders.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmacy & Pharmacology
dc.subjectantimicrobial synergismen
dc.subjectCitrus limonen
dc.subjectcytotoxic activityen
dc.subjectessential oilen
dc.subjectMelaleuca alternifoliaen
dc.subjectPiper nigrumen
dc.titleAntimicrobial synergism and cytotoxic properties of Citrus limon L., Piper nigrum L. and Melaleuca alternifolia (Maiden and Betche) Cheel essential oilsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМарковић, Татјана; Соковић, Марина; Марковић, Дејан; Костић, Марина; Јовановић, Катарина К.; Глигоријевић, Невенка; Радуловић, Синиша; Гламочлија, Јасмина; Николић, Милош;
dc.citation.volume69
dc.citation.issue11
dc.citation.spage1606
dc.citation.epage1614
dc.citation.other69(11): 1606-1614
dc.citation.rankM22
dc.identifier.wos000412309100019
dc.identifier.doi10.1111/jphp.12792
dc.identifier.pmid28815601
dc.identifier.scopus2-s2.0-85030625984
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу