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dc.creatorRadović, Nikola
dc.creatorNikolić-Jakoba, Nataša
dc.creatorPetrović, Nina
dc.creatorMilosavljević, Aleksandra
dc.creatorBrković, Božidar
dc.creatorRoganović, Jelena
dc.date.accessioned2020-07-02T13:15:16Z
dc.date.available2020-07-02T13:15:16Z
dc.date.issued2018
dc.identifier.issn0303-6979
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/2282
dc.description.abstractAimRecent studies point at the crucial role of epigenetic mechanisms in the development of multifactorial diseases such as periodontitis and diabetes mellitus (DM) type 2. In addition, circulatory microRNAs (miRs) have emerged as novel biomarkers for various diseases. Aim of this study was to investigate the levels of miR-146a and miR-155 and superoxide dismutase (SOD) activity in gingival crevicular fluid (GCF) of periodontitis patients with (CPDM) and without (CP) DM type 2 as well as in periodontally healthy, control groups (PHDM and PH, respectively). Material and methodsmiR modulation was analysed using quantitative real-time PCR while SOD activity was measured spectrophotometrically. ResultsThe upregulation of miR-146a and miR-155 was observed in CP and CPDM patients' baseline, while the levels decreased after 6weeks of the non-surgical therapy to the levels comparable to PH and PHDM, respectively. Expression levels of miRs positively correlated with SOD activity. Levels of miR-146a were higher in PHDM compared to PH patients. Multivariate analysis revealed that levels of miR-146a and miR-155 were significantly associated with periodontitis when adjusting for age and gender. ConclusionsmiR-146a and miR-155 may be considered as possible novel biomarkers for periodontitis in non-diabetic and type 2 diabetic patients.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175021/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Clinical Periodontology
dc.subjectdiabetes mellitus type 2en
dc.subjectepigenetic modulatorsen
dc.subjectmiR-146aen
dc.subjectmiR-155en
dc.subjectperiodontitisen
dc.titleMicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилосављевић, Aлександра; Радовић, Никола; Рогановић, Јелена; Брковић, Божидар; Николић-Јакоба, Наташа; Петровић, Нина;
dc.citation.volume45
dc.citation.issue6
dc.citation.spage663
dc.citation.epage671
dc.citation.other45(6): 663-671
dc.citation.rankaM21
dc.description.otherPeer-reviewed manuscript: [http://smile.stomf.bg.ac.rs/handle/123456789/2519]
dc.identifier.wos000434128500003
dc.identifier.doi10.1111/jcpe.12888
dc.identifier.pmid29517812
dc.identifier.scopus2-s2.0-85047460731
dc.identifier.rcubconv_3528
dc.type.versionpublishedVersion


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