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dc.creatorGrubiša, Ivana
dc.creatorOtašević, Petar
dc.creatorVucinić, Nada
dc.creatorMiličić, Biljana
dc.creatorJozić, Tanja
dc.creatorKrstić, Slobodan
dc.creatorMilašin, Jelena
dc.date.accessioned2020-07-02T13:15:35Z
dc.date.available2020-07-02T13:15:35Z
dc.date.issued2018
dc.identifier.issn1415-4757
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/2287
dc.description.abstractOxidative stress (OS) plays an important role in atherogenesis and since glutathione S-transferases (GSTs) provide protection against OS, we have tested the hypothesis that deletion polymorphisms in two GSTs (GSTM1 and GSTT1) may affect the risk of developing atherosclerosis. A total of 382 individuals (200 patients with atherosclerosis and 182 healthy controls) were included in this association study. Genomic DNA was isolated from peripheral blood cells or from buccal epithelial cells and genotyping was performed using multiplex-PCR or real-time PCR methods. GSTM1 null genotype was significantly more frequent in atherosclerotic patients than in controls (52.0% vs 34.1%) and individuals with the GSTM1 null genotype had an approximately 2-fold increase in atherosclerosis risk (OR: 2.1, 95%CI=1.39-3.17, P=0.0004). GSTT1 null genotype alone did not show a statistically significant effect on atherosclerosis risk modulation, but the association approached significance (OR: 1.57, 95%CI=0.94-2.64, P=0.08). The combined analysis showed that the presence of both genes had a protective effect against atherosclerosis (OR=0.55, 95%CI=0.37-0.83, P=0.005) while double null genotypes led to a robust atherosclerosis risk increase (OR: 8.14, 95%CI=2.41-27.51, P lt 0.0001). This study demonstrated that the GSTM1 null and combined GSTM1/GSTT1 null genotypes are susceptibility factors for development of atherosclerosis in a Serbian population.en
dc.publisherSoc Brasil Genetica, Ribeirao Pret
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceGenetics & Molecular Biology
dc.subjectatherosclerosisen
dc.subjectgene polymorphismsen
dc.subjectglutathione S-transferasesen
dc.subjectoxidative stressen
dc.titleCombined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian populationen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractОташевић, Петар; Јозић, Тања; Крстић, Слободан; Вуцинић, Нада; Грубиша, Ивана; Милашин, Јелена; Миличић, Биљана;
dc.citation.volume41
dc.citation.issue1
dc.citation.spage35
dc.citation.epage40
dc.citation.other41(1): 35-40
dc.citation.rankM23
dc.identifier.wos000430181600005
dc.identifier.doi10.1590/1678-4685-GMB-2017-0034
dc.identifier.pmid29658969
dc.identifier.scopus2-s2.0-85045375044
dc.identifier.fulltexthttps://smile.stomf.bg.ac.rs/bitstream/id/851/2282.pdf
dc.type.versionpublishedVersion


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