As an alternative to MTA, a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized, and its biocompatibility has been studied in many in vitro and in vivo studies. The current study aims to evaluate a subchronic systemic toxicity of ALBO-MPSA on the rat animal model, as a continuation of the previous studies. Biochemical parameters of blood and histological parameters of the liver, kidneys, and spleen of the rats were analyzed after 120 days of consumption of the aqueous extract of ALBO-MPSA. The results showed no myelotoxic effect or autoimmune effect on peripheral blood cells and no pathological effect on the liver, kidney, and spleen tissues. Besides, no changes in the skin and hair of the rats, neither the change in the consumption of food and water, nor the change in their usual behavior were noticed during the experiment.
Source:
Advances in Materials Science & Engineering, 2018, 2018
TY - JOUR
AU - Jokanović, Vukoman
AU - Čolović, Božana
AU - Prokić, Bogomir Bolka
AU - Tomanović, Nada
AU - Popović-Bajić, Marijana
AU - Živković, Slavoljub
PY - 2018
UR - https://smile.stomf.bg.ac.rs/handle/123456789/2313
AB - As an alternative to MTA, a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized, and its biocompatibility has been studied in many in vitro and in vivo studies. The current study aims to evaluate a subchronic systemic toxicity of ALBO-MPSA on the rat animal model, as a continuation of the previous studies. Biochemical parameters of blood and histological parameters of the liver, kidneys, and spleen of the rats were analyzed after 120 days of consumption of the aqueous extract of ALBO-MPSA. The results showed no myelotoxic effect or autoimmune effect on peripheral blood cells and no pathological effect on the liver, kidney, and spleen tissues. Besides, no changes in the skin and hair of the rats, neither the change in the consumption of food and water, nor the change in their usual behavior were noticed during the experiment.
PB - Hindawi Ltd, London
T2 - Advances in Materials Science & Engineering
T1 - Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates
VL - 2018
DO - 10.1155/2018/8493439
ER -
@article{
author = "Jokanović, Vukoman and Čolović, Božana and Prokić, Bogomir Bolka and Tomanović, Nada and Popović-Bajić, Marijana and Živković, Slavoljub",
year = "2018",
abstract = "As an alternative to MTA, a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized, and its biocompatibility has been studied in many in vitro and in vivo studies. The current study aims to evaluate a subchronic systemic toxicity of ALBO-MPSA on the rat animal model, as a continuation of the previous studies. Biochemical parameters of blood and histological parameters of the liver, kidneys, and spleen of the rats were analyzed after 120 days of consumption of the aqueous extract of ALBO-MPSA. The results showed no myelotoxic effect or autoimmune effect on peripheral blood cells and no pathological effect on the liver, kidney, and spleen tissues. Besides, no changes in the skin and hair of the rats, neither the change in the consumption of food and water, nor the change in their usual behavior were noticed during the experiment.",
publisher = "Hindawi Ltd, London",
journal = "Advances in Materials Science & Engineering",
title = "Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates",
volume = "2018",
doi = "10.1155/2018/8493439"
}
Jokanović, V., Čolović, B., Prokić, B. B., Tomanović, N., Popović-Bajić, M.,& Živković, S.. (2018). Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates. in Advances in Materials Science & Engineering
Hindawi Ltd, London., 2018.
https://doi.org/10.1155/2018/8493439
Jokanović V, Čolović B, Prokić BB, Tomanović N, Popović-Bajić M, Živković S. Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates. in Advances in Materials Science & Engineering. 2018;2018.
doi:10.1155/2018/8493439 .
Jokanović, Vukoman, Čolović, Božana, Prokić, Bogomir Bolka, Tomanović, Nada, Popović-Bajić, Marijana, Živković, Slavoljub, "Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates" in Advances in Materials Science & Engineering, 2018 (2018),
https://doi.org/10.1155/2018/8493439 . .
