Testing of correlation of heart weight and heart rupture in 119 cases of deceased of acute myocardial infarction

Abstract

Introduction. Cardiovascular and blood vessel diseases are the most common cause of death, which is shown by data obtained in our and foreign authors' research, and acute myocardial infarction is the most common emergency in internal medicine and its mortality is very high, about one third of total mortality. The aim of this paper is to determine whether there is a statistically significant difference in heart weight in deceased patients with acute myocardial infarction (AMI) with heart rupture and with AMI without heart rupture. Methods. The research material is made up of 119 autopsied patients at the Institute of Pathology of the University of Kragujevac Medical Faculty and Clinical Center Kragujevac. The following pathological morphological research methods were applied: autopsy, macroscopic diagnostics and microscopic analysis. In addition, a statistical processing of results was performed, and the Pharmocologic Circulapon System Student's t-test statistical software package was used to test the significance of differences. A value of p lt 0.05 was considered as a statistically significant difference, and a value of p lt 0.01 as highly significant. Results and Discussion. Out of 119 cases of AMI deaths, of which 74 male and 45 female, heart rupture was found in 21 cases. Of the 74 men who died of AMI, 13 had a rupture, and of the 45 women who died of AMI, 8 had a rupture. The heart weight was measured in each respondent who died of AMI and the correlation between heart weight and rupture was investigated. The study showed that there was a statistically significant difference (p lt 0.05) in the average heart weight between the autopsied who had and those who did not have heart rupture, and that those who did not have heart rupture had significantly more heart weight. The study showed that there was a statistically significant difference (p lt 0.05) in the average heart weight between the autopsied men who had and those who did not have heart rupture. The heart of those men who did not have heart rupture had more weight. There were no statistically significant differences (p>0.05) in the mean heart weight between the autopsied women who had and those who did not have heart rupture. Conclusion. The study showed the difference in the heart weight of autopsied patients who had and those who did not have heart rupture, and that those who did not have heart rupture had significantly more heart weight. In relation to sex, the heart of those men who did not have heart rupture had more weight, while in women there are no statistically significant differences (p>0.05) in the average heart weight in those with and without rupture of the heart.

Uvod. Bolesti srca i krvnih sudova predstavljaju najčešći uzrok smrti, što pokazuju podaci dobijeni u istraživanjima naših i stranih autora, a akutni infarkt miokarda je najčešće urgentno stanje u internoj medicini i mortalitet mu je veoma visok, jer od ukupnog mortaliteta jedna trećina otpada na infarkt miokarda. Cilj rada je bio da utvrdimo postoji li statistički značajna razlika u težini srca kod umrlih pacijenata sa akutnim infarktom miokarda (AIM) sa rupturom srca i sa AIM-om bez rupture srca. Metode. Istraživački materijal čini 119 obdukovanih pacijenata u Institutu za patologiju Medicinskog fakulteta u Kragujevcu i KBC Kragujevac. Primenjene su patološko morfološke metode istraživanja: obdukcija, makroskopska dijagnostika i mikroskopska analiza. Pored toga, vršena je statistička obrada rezultata, a za testiranje značajnosti razlika korišćen je Studentov test softverski paket statističkih testova Pharmocologic Circulapon Sistem. Kao statistički značajna smatrana je razlika ako je p lt 0,05 i visoko značajna ako je p lt 0,01. Rezultati i diskusija. Od 119 slučajeva umrlih od AIM-a, od čega je 74 muškarca i 45 žena, ruptura srca nađena je u 21 slučaju. Od 74 muškarca koji su umrli od AIM-a, 13 je imalo rupturu, a od 45 žena koje su umrle od AIM-a, osam je imalo rupturu. Merena je težina srca kod svakog ispitanika koji je umro od AIM-a i ispitivana povezanost težine srca sa rupturom. Ispitivanje je pokazalo da postoji statistički značajna razlika (p lt 0,05) u prosečnoj težini srca između obdukovanih koji su imali i onih koji nisu imali rupturu srca i da je značajno teže srce onih koji nisu imali rupturu srca. Ispitivanje je pokazalo da postoji statistički značajna razlika (p lt 0,05) u prosečnoj težini srca između obdukovanih muškaraca koji su imali i onih koji nisu imali rupturu srca. Značajno je teže srce onih muškaraca koji nisu imali rupturu srca. Nema statistički značajnih razlika (p>0,05) u prosečnoj težini srca između obdukovanih žena koje su imale i onih koje nisu imale rupturu srca. Zaključak. Ispitivanje je pokazalo razliku u težini srca između obdukovanih koji su imali i onih koji nisu imali rupturu srca i da je značajno teže srce onih koji nisu imali rupturu srca. U odnosu na pol značajno je teže srce onih muškaraca koji nisu imali rupturu srca, dok kod žena nema statistički značajnih razlika (p>0,05) u prosečnoj težini srca kod onih sa i bez rupture srca.