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The role of interleukin-6 in pathogenesis of chronic periapical lesions

Uloga interleukina-6 u patogenezi hroničnih periapeksnih lezija

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2018
2361.pdf (533.0Kb)
Authors
Popović, Jelena
Cvetković, Tatjana
Džopalić, Tanja
Nikolić, Marija
Mitić, Aleksandar
Barac, Radomir
Živković, Slavoljub
Article (Published version)
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Abstract
Introduction Cytokine network plays an important role in pathogenesis of chronic periapical lesions. The aim of this study was to determine the concentration of interleukin-6 (IL-6) in tissue homogenates of human periapical lesions and correlate its levels with symptomatology and size of the lesions. Materials and Methods 93 samples of chronic periapical lesions were obtained after extraction of teeth. Samples were divided according to the clinical presentation as symptomatic and asymptomatic, and according to the size as large and small. The concentration of IL-6 was analyzed using ELISA. Results Statistically significant difference in IL-6 concentration was observed in symptomatic lesions compared to asymptomatic (p lt 0.001). Analysis showed statistically higher concentration in large symptomatic lesions compared to large asymptomatic lesions (p lt 0.001), and in small symptomatic lesions compared to small asymptomatic (p lt 0.05). Higher production of IL-6 was observed in large les...ions compared to small but this difference was not statistically significant. Conclusion Higher concentration of IL-6 in lesions with expressed clinical symptoms as well as in large lesions indicates that IL-6 is an important factor responsible for the progression of lesions and bone resorption.

Uvod Mreža citokina igra značajnu ulogu u patogenezi hroničnih periapeksnih lezija. Cilj studije je bio da se odredi koncentracija IL-6 u tkivnim homogenatima hroničnih periapeksnih lezija i da se proveri korelacija sa simptomatologijom i veličinom lezija. Materijal i metode Ispitana su 93 uzorka hroničnih periapeksnih lezija dobijenih nakon ekstrakcije zuba. Uzorci lezija su podeljeni prema simptomatologiji pacijenata na simptomatske i asimptomatske, a prema veličini na velike i male. Koncentracija IL-6 je ispitivana pomoću ELISA testa, a dobijene vrednosti su analizirane u odnosu na grupe. Rezultati Statistički značajna razlika u koncentraciji IL-6 je uočena u grupi simptomatskih lezija u poređenju sa asimptomatskim (p lt 0,001). Analiza je pokazala i statistički značajno veću koncentraciju u velikim simptomatskim lezijama u odnosu na velike asimptomatske (p lt 0,001) i u malim simptomatskim lezijama u odnosu na male asimptomatske (p lt 0,05). Zapažena je i povećana produkciju ...IL-6 u velikim lezijama u odnosu na male, međutim, razlika nije bila statistički značajna. Zaključak Veća koncentracija IL-6 u lezijama sa izraženim kliničkim simptomima kao i velikim lezijama ukazuje na njegovu važnu ulogu u progresiji periapeksnih lezija i koštane resorpcije. .

Keywords:
periapical lesions / cytokines / IL-6 / periapeksne lezije / citokini / IL-6
Source:
Stomatološki glasnik Srbije, 2018, 65, 3, 126-132
Publisher:
  • Srpsko lekarsko društvo - Stomatološka sekcija, Beograd

DOI: 10.2478/sdj-2018-0012

ISSN: 0039-1743

[ Google Scholar ]
URI
https://smile.stomf.bg.ac.rs/handle/123456789/2366
Collections
  • Radovi istraživača
Institution/Community
Stomatološki fakultet
TY  - JOUR
AU  - Popović, Jelena
AU  - Cvetković, Tatjana
AU  - Džopalić, Tanja
AU  - Nikolić, Marija
AU  - Mitić, Aleksandar
AU  - Barac, Radomir
AU  - Živković, Slavoljub
PY  - 2018
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2366
AB  - Introduction Cytokine network plays an important role in pathogenesis of chronic periapical lesions. The aim of this study was to determine the concentration of interleukin-6 (IL-6) in tissue homogenates of human periapical lesions and correlate its levels with symptomatology and size of the lesions. Materials and Methods 93 samples of chronic periapical lesions were obtained after extraction of teeth. Samples were divided according to the clinical presentation as symptomatic and asymptomatic, and according to the size as large and small. The concentration of IL-6 was analyzed using ELISA. Results Statistically significant difference in IL-6 concentration was observed in symptomatic lesions compared to asymptomatic (p lt 0.001). Analysis showed statistically higher concentration in large symptomatic lesions compared to large asymptomatic lesions (p lt 0.001), and in small symptomatic lesions compared to small asymptomatic (p lt 0.05). Higher production of IL-6 was observed in large lesions compared to small but this difference was not statistically significant. Conclusion Higher concentration of IL-6 in lesions with expressed clinical symptoms as well as in large lesions indicates that IL-6 is an important factor responsible for the progression of lesions and bone resorption.
AB  - Uvod Mreža citokina igra značajnu ulogu u patogenezi hroničnih periapeksnih lezija. Cilj studije je bio da se odredi koncentracija IL-6 u tkivnim homogenatima hroničnih periapeksnih lezija i da se proveri korelacija sa simptomatologijom i veličinom lezija. Materijal i metode Ispitana su 93 uzorka hroničnih periapeksnih lezija dobijenih nakon ekstrakcije zuba. Uzorci lezija su podeljeni prema simptomatologiji pacijenata na simptomatske i asimptomatske, a prema veličini na velike i male. Koncentracija IL-6 je ispitivana pomoću ELISA testa, a dobijene vrednosti su analizirane u odnosu na grupe. Rezultati Statistički značajna razlika u koncentraciji IL-6 je uočena u grupi simptomatskih lezija u poređenju sa asimptomatskim (p  lt  0,001). Analiza je pokazala i statistički značajno veću koncentraciju u velikim simptomatskim lezijama u odnosu na velike asimptomatske (p  lt  0,001) i u malim simptomatskim lezijama u odnosu na male asimptomatske (p  lt  0,05). Zapažena je i povećana produkciju IL-6 u velikim lezijama u odnosu na male, međutim, razlika nije bila statistički značajna. Zaključak Veća koncentracija IL-6 u lezijama sa izraženim kliničkim simptomima kao i velikim lezijama ukazuje na njegovu važnu ulogu u progresiji periapeksnih lezija i koštane resorpcije. .
PB  - Srpsko lekarsko društvo - Stomatološka sekcija, Beograd
T2  - Stomatološki glasnik Srbije
T1  - The role of interleukin-6 in pathogenesis of chronic periapical lesions
T1  - Uloga interleukina-6 u patogenezi hroničnih periapeksnih lezija
VL  - 65
IS  - 3
SP  - 126
EP  - 132
DO  - 10.2478/sdj-2018-0012
ER  - 
@article{
author = "Popović, Jelena and Cvetković, Tatjana and Džopalić, Tanja and Nikolić, Marija and Mitić, Aleksandar and Barac, Radomir and Živković, Slavoljub",
year = "2018",
abstract = "Introduction Cytokine network plays an important role in pathogenesis of chronic periapical lesions. The aim of this study was to determine the concentration of interleukin-6 (IL-6) in tissue homogenates of human periapical lesions and correlate its levels with symptomatology and size of the lesions. Materials and Methods 93 samples of chronic periapical lesions were obtained after extraction of teeth. Samples were divided according to the clinical presentation as symptomatic and asymptomatic, and according to the size as large and small. The concentration of IL-6 was analyzed using ELISA. Results Statistically significant difference in IL-6 concentration was observed in symptomatic lesions compared to asymptomatic (p lt 0.001). Analysis showed statistically higher concentration in large symptomatic lesions compared to large asymptomatic lesions (p lt 0.001), and in small symptomatic lesions compared to small asymptomatic (p lt 0.05). Higher production of IL-6 was observed in large lesions compared to small but this difference was not statistically significant. Conclusion Higher concentration of IL-6 in lesions with expressed clinical symptoms as well as in large lesions indicates that IL-6 is an important factor responsible for the progression of lesions and bone resorption., Uvod Mreža citokina igra značajnu ulogu u patogenezi hroničnih periapeksnih lezija. Cilj studije je bio da se odredi koncentracija IL-6 u tkivnim homogenatima hroničnih periapeksnih lezija i da se proveri korelacija sa simptomatologijom i veličinom lezija. Materijal i metode Ispitana su 93 uzorka hroničnih periapeksnih lezija dobijenih nakon ekstrakcije zuba. Uzorci lezija su podeljeni prema simptomatologiji pacijenata na simptomatske i asimptomatske, a prema veličini na velike i male. Koncentracija IL-6 je ispitivana pomoću ELISA testa, a dobijene vrednosti su analizirane u odnosu na grupe. Rezultati Statistički značajna razlika u koncentraciji IL-6 je uočena u grupi simptomatskih lezija u poređenju sa asimptomatskim (p  lt  0,001). Analiza je pokazala i statistički značajno veću koncentraciju u velikim simptomatskim lezijama u odnosu na velike asimptomatske (p  lt  0,001) i u malim simptomatskim lezijama u odnosu na male asimptomatske (p  lt  0,05). Zapažena je i povećana produkciju IL-6 u velikim lezijama u odnosu na male, međutim, razlika nije bila statistički značajna. Zaključak Veća koncentracija IL-6 u lezijama sa izraženim kliničkim simptomima kao i velikim lezijama ukazuje na njegovu važnu ulogu u progresiji periapeksnih lezija i koštane resorpcije. .",
publisher = "Srpsko lekarsko društvo - Stomatološka sekcija, Beograd",
journal = "Stomatološki glasnik Srbije",
title = "The role of interleukin-6 in pathogenesis of chronic periapical lesions, Uloga interleukina-6 u patogenezi hroničnih periapeksnih lezija",
volume = "65",
number = "3",
pages = "126-132",
doi = "10.2478/sdj-2018-0012"
}
Popović, J., Cvetković, T., Džopalić, T., Nikolić, M., Mitić, A., Barac, R.,& Živković, S.. (2018). The role of interleukin-6 in pathogenesis of chronic periapical lesions. in Stomatološki glasnik Srbije
Srpsko lekarsko društvo - Stomatološka sekcija, Beograd., 65(3), 126-132.
https://doi.org/10.2478/sdj-2018-0012
Popović J, Cvetković T, Džopalić T, Nikolić M, Mitić A, Barac R, Živković S. The role of interleukin-6 in pathogenesis of chronic periapical lesions. in Stomatološki glasnik Srbije. 2018;65(3):126-132.
doi:10.2478/sdj-2018-0012 .
Popović, Jelena, Cvetković, Tatjana, Džopalić, Tanja, Nikolić, Marija, Mitić, Aleksandar, Barac, Radomir, Živković, Slavoljub, "The role of interleukin-6 in pathogenesis of chronic periapical lesions" in Stomatološki glasnik Srbije, 65, no. 3 (2018):126-132,
https://doi.org/10.2478/sdj-2018-0012 . .

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