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dc.creatorMagić, Marko
dc.creatorZeljić, Katarina
dc.creatorJovandić, Stevo
dc.creatorStepić, Jelena
dc.creatorPejović, Marko
dc.creatorČolić, Snježana
dc.creatorMagić, Zvonko
dc.creatorSupić, Gordana
dc.date.accessioned2020-07-02T13:21:34Z
dc.date.available2020-07-02T13:21:34Z
dc.date.issued2019
dc.identifier.issn1432-6981
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/2382
dc.description.abstractObjectivesGenetic variants in the hedgehog signaling pathway and VDR gene are involved in inflammatory responses and neoplastic transformation. Current study investigated whether single-nucleotide polymorphisms in the hedgehog pathway genes PTCH1, GLI1, SMO, and VDR contribute to susceptibility to odontogenic cystic lesions, odontogenic keratocysts, or inflammatory radicular cysts.Material and methodsCurrent study examined polymorphisms of PTCH1 (rs357564) and PTCH1 insertion (IVS1-83), GLI1 (rs2228224, rs2228226), SMO (rs2228617), and VDR (rs2228570, rs731236, rs7975232). A case-control study was conducted on 41 keratocyst cases, 43 radicular cyst cases, and control group of 93 healthy individuals without cystic lesions, radiographically confirmed. Single-nucleotide polymorphisms were assessed by real-time and TaqMan SNP genotyping assays, while PTCH1 insertion 18bp IVS1-83 polymorphism was determined by PCR.ResultsThe difference in genotype distribution between keratocyst cases and control group was observed for PTCH1 IVS1-83 and GLI1 rs2228224 polymorphism (p=0.022, p=0.030, respectively). Homozygous mutant GG genotype within GLI1 rs2228224 is associated with increased susceptibility for odontogenous keratocysts, with adjusted odds ratio of 4.098 (confidence interval of 1.482-11.328, p=0.007).ConclusionGLI1 rs2228224 and PTCH1 polymorphisms could predispose to odontogenic keratocysts.Clinical relevanceVariants in hedgehog signaling pathway genes, such as GLI1 and PTCH1, and vitamin D receptor gene, might be considered as molecular risk factors in odontogenic cystic lesions and potential targets for novel therapeutic approaches.en
dc.publisherSpringer Heidelberg, Heidelberg
dc.relationFaculty of Medicine, Military Medical Academy, Belgrade, Serbia [MFVMA/11/16-18]
dc.rightsrestrictedAccess
dc.sourceClinical Oral Investigations
dc.subjectHedgehog signalingen
dc.subjectPolymorphismen
dc.subjectGLI1en
dc.subjectPTCH1en
dc.subjectVitamin D receptoren
dc.subjectOdontogenic keratocystsen
dc.titleHedgehog signaling pathway and vitamin D receptor gene variants as potential risk factors in odontogenic cystic lesionsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСупић, Гордана; Зељић, Катарина; Јовандић, Стево; Магић, Звонко; Чолић, Сњежана; Пејовић, Марко; Степић, Јелена; Магић, Марко;
dc.citation.volume23
dc.citation.issue6
dc.citation.spage2675
dc.citation.epage2684
dc.citation.other23(6): 2675-2684
dc.citation.rankM21
dc.identifier.wos000467444800012
dc.identifier.doi10.1007/s00784-018-2686-5
dc.identifier.pmid30334169
dc.identifier.scopus2-s2.0-85055490930
dc.identifier.rcubconv_3625
dc.type.versionpublishedVersion


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