Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study

2019
Аутори
Lazarević, Miloš
Milošević, Maja

Petrović, Nada
Petrović, Slobodan
Damante, Giuseppe
Milašin, Jelena

Milovanović, Branislav
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background/Aim: Current approaches in therapy of head and neck cancers are surgery, radiotherapy and chemotherapy. However, recurrence, development of multidrug resistance, side effects, and high costs of therapy are significant problems which point to the need for more efficient and less toxic drugs and interventions. Material and Methods: Eight essential oils obtained from Thymus serpyllum, Mentha piperita, Juniperus communis, Rosmarinus officinalis, Melissa officinalis, Achillea millefolium, Zingiber officinale, and Helichrysum arenarium were tested for their anti-proliferative on oral squamous cell carcinoma (OSCC) culture and SCC-25 cell line. Cytotoxicity assays (MTT and Neutral red) were used to detect the effect of the mentioned essential oils. Results: T. serpyllum, M. piperita, J. communis, and R. officinalis essential oils exhibited the best anti-proliferative effect, on both types of cells. M. piperita had the greatest effect on SCC-25 cell line (4,5% of viable cells) and O...SCC cells (7,2% of viable cells). Overall, cytotoxicity was higher in OSCC than in SCC-25 cell line. Conclusions: This study showed a clear anti-proliferative effect of four essential oils, in vitro making them novel potential antineoplastic agents.
Кључне речи:
essential oils / cytotoxicity / squamous cell carcinoma / cell culturesИзвор:
Balkan Journal of Dental Medicine, 2019, 23, 2, 73-79Издавач:
- Udruženje stomatologa Balkana
Финансирање / пројекти:
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Lazarević, Miloš AU - Milošević, Maja AU - Petrović, Nada AU - Petrović, Slobodan AU - Damante, Giuseppe AU - Milašin, Jelena AU - Milovanović, Branislav PY - 2019 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2403 AB - Background/Aim: Current approaches in therapy of head and neck cancers are surgery, radiotherapy and chemotherapy. However, recurrence, development of multidrug resistance, side effects, and high costs of therapy are significant problems which point to the need for more efficient and less toxic drugs and interventions. Material and Methods: Eight essential oils obtained from Thymus serpyllum, Mentha piperita, Juniperus communis, Rosmarinus officinalis, Melissa officinalis, Achillea millefolium, Zingiber officinale, and Helichrysum arenarium were tested for their anti-proliferative on oral squamous cell carcinoma (OSCC) culture and SCC-25 cell line. Cytotoxicity assays (MTT and Neutral red) were used to detect the effect of the mentioned essential oils. Results: T. serpyllum, M. piperita, J. communis, and R. officinalis essential oils exhibited the best anti-proliferative effect, on both types of cells. M. piperita had the greatest effect on SCC-25 cell line (4,5% of viable cells) and OSCC cells (7,2% of viable cells). Overall, cytotoxicity was higher in OSCC than in SCC-25 cell line. Conclusions: This study showed a clear anti-proliferative effect of four essential oils, in vitro making them novel potential antineoplastic agents. PB - Udruženje stomatologa Balkana T2 - Balkan Journal of Dental Medicine T1 - Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study VL - 23 IS - 2 SP - 73 EP - 79 DO - 10.2478/bjdm-2019-0014 ER -
@article{ author = "Lazarević, Miloš and Milošević, Maja and Petrović, Nada and Petrović, Slobodan and Damante, Giuseppe and Milašin, Jelena and Milovanović, Branislav", year = "2019", abstract = "Background/Aim: Current approaches in therapy of head and neck cancers are surgery, radiotherapy and chemotherapy. However, recurrence, development of multidrug resistance, side effects, and high costs of therapy are significant problems which point to the need for more efficient and less toxic drugs and interventions. Material and Methods: Eight essential oils obtained from Thymus serpyllum, Mentha piperita, Juniperus communis, Rosmarinus officinalis, Melissa officinalis, Achillea millefolium, Zingiber officinale, and Helichrysum arenarium were tested for their anti-proliferative on oral squamous cell carcinoma (OSCC) culture and SCC-25 cell line. Cytotoxicity assays (MTT and Neutral red) were used to detect the effect of the mentioned essential oils. Results: T. serpyllum, M. piperita, J. communis, and R. officinalis essential oils exhibited the best anti-proliferative effect, on both types of cells. M. piperita had the greatest effect on SCC-25 cell line (4,5% of viable cells) and OSCC cells (7,2% of viable cells). Overall, cytotoxicity was higher in OSCC than in SCC-25 cell line. Conclusions: This study showed a clear anti-proliferative effect of four essential oils, in vitro making them novel potential antineoplastic agents.", publisher = "Udruženje stomatologa Balkana", journal = "Balkan Journal of Dental Medicine", title = "Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study", volume = "23", number = "2", pages = "73-79", doi = "10.2478/bjdm-2019-0014" }
Lazarević, M., Milošević, M., Petrović, N., Petrović, S., Damante, G., Milašin, J.,& Milovanović, B.. (2019). Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study. in Balkan Journal of Dental Medicine Udruženje stomatologa Balkana., 23(2), 73-79. https://doi.org/10.2478/bjdm-2019-0014
Lazarević M, Milošević M, Petrović N, Petrović S, Damante G, Milašin J, Milovanović B. Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study. in Balkan Journal of Dental Medicine. 2019;23(2):73-79. doi:10.2478/bjdm-2019-0014 .
Lazarević, Miloš, Milošević, Maja, Petrović, Nada, Petrović, Slobodan, Damante, Giuseppe, Milašin, Jelena, Milovanović, Branislav, "Cytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro study" in Balkan Journal of Dental Medicine, 23, no. 2 (2019):73-79, https://doi.org/10.2478/bjdm-2019-0014 . .