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dc.creatorLazarević, Miloš
dc.creatorMilošević, Maja
dc.creatorPetrović, Nada
dc.creatorPetrović, Slobodan
dc.creatorDamante, Giuseppe
dc.creatorMilašin, Jelena
dc.creatorMilovanović, Branislav
dc.date.accessioned2020-07-02T13:22:54Z
dc.date.available2020-07-02T13:22:54Z
dc.date.issued2019
dc.identifier.issn2335-0245
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/2403
dc.description.abstractBackground/Aim: Current approaches in therapy of head and neck cancers are surgery, radiotherapy and chemotherapy. However, recurrence, development of multidrug resistance, side effects, and high costs of therapy are significant problems which point to the need for more efficient and less toxic drugs and interventions. Material and Methods: Eight essential oils obtained from Thymus serpyllum, Mentha piperita, Juniperus communis, Rosmarinus officinalis, Melissa officinalis, Achillea millefolium, Zingiber officinale, and Helichrysum arenarium were tested for their anti-proliferative on oral squamous cell carcinoma (OSCC) culture and SCC-25 cell line. Cytotoxicity assays (MTT and Neutral red) were used to detect the effect of the mentioned essential oils. Results: T. serpyllum, M. piperita, J. communis, and R. officinalis essential oils exhibited the best anti-proliferative effect, on both types of cells. M. piperita had the greatest effect on SCC-25 cell line (4,5% of viable cells) and OSCC cells (7,2% of viable cells). Overall, cytotoxicity was higher in OSCC than in SCC-25 cell line. Conclusions: This study showed a clear anti-proliferative effect of four essential oils, in vitro making them novel potential antineoplastic agents.en
dc.publisherUdruženje stomatologa Balkana
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceBalkan Journal of Dental Medicine
dc.subjectessential oilsen
dc.subjectcytotoxicityen
dc.subjectsquamous cell carcinomaen
dc.subjectcell culturesen
dc.titleCytotoxic effects of different aromatic plants essential oils on oral squamous cell carcinoma: An in vitro studyen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractПетровић, Слободан; Лазаревић, Милош; Милашин, Јелена; Милошевић, Маја; Даманте, Гиусеппе; Миловановић, Бранислав; Петровић, Нада;
dc.citation.volume23
dc.citation.issue2
dc.citation.spage73
dc.citation.epage79
dc.citation.other23(2): 73-79
dc.citation.rankM51
dc.identifier.doi10.2478/bjdm-2019-0014
dc.identifier.fulltexthttp://smile.stomf.bg.ac.rs/bitstream/id/937/2398.pdf
dc.identifier.rcubconv_2571
dc.type.versionpublishedVersion


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