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dc.creatorPetrović, Milan
dc.creatorJelovac, Drago
dc.creatorAntić, Svetlana
dc.creatorAntunović, Marija
dc.creatorLukić, Nikola
dc.creatorSabani, Melvil
dc.creatorMudrak, Joerg
dc.creatorJezdić, Zoran
dc.creatorPucar, Ana
dc.creatorStefanović, Aleksandar
dc.creatorKuzmanović, Čedomir
dc.creatorNikolić, Danilo
dc.creatorKonstantinović, Vitomir
dc.date.accessioned2020-07-02T13:25:25Z
dc.date.available2020-07-02T13:25:25Z
dc.date.issued2019
dc.identifier.issn2314-6133
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/2443
dc.description.abstractThis retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from 2009 to 2018. Clinical, radiological examination (Orthopantomograph and CBCT) and biopsy were performed in order to achieve diagnosis. Demographic and clinical variables were taken into consideration: sex, age, primary disease, medication type, mode of delivery, anatomic location, drug treatment duration, timing of tooth extraction, chemotherapy, presence of bone metastasis, aetiology of MRONJ, disease stage, and treatment modality. MRONJ developed under osteoporosis and malignant disease in 11 and 21 patients, respectively. MRONJ development was triggered by tooth extraction or trauma in 30 out of 32 cases, whereas the two patients developed MRONJ spontaneously. Stages I, II, and III were confirmed in 5 (16%), 18 (58%), and 9 (28%) patients, respectively. Mandible was affected in 23 (72%) patients. MRONJ was treated in our department by conservative and surgical modality. In this study we found that 65% of all patients were classified in the cured/improvement group and 35% in the stable/progression group. The female gender, osteoporosis as primary disease, oral regime intake, shorter period on BPs, earlier stage of disease, and specific anatomic localisation (frontal and premolar maxilla) were factors associated with better response to therapy and favourable clinical outcome. Comprehensive treatment protocol and further randomized studies are necessary for further improvements.en
dc.publisherHindawi Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45005/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceBiomed Research International
dc.titleMedication-Related Osteonecrosis of the Jaws: Two Center Retrospective Cohort Studiesen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractЈеловац, Драго; Николић, Данило; Јездић, Зоран; Пуцар, Aна; Кузмановић, Чедомир; Aнтић, Светлана; Aнтуновић, Марија; Петровић, Милан; Лукић, Никола; Сабани, Мелвил; Константиновић, Витомир; Стефановић, Aлександар; Мудрак, Јоерг;
dc.citation.volume2019
dc.citation.other2019: -
dc.citation.rankM22
dc.identifier.wos000463067100001
dc.identifier.doi10.1155/2019/8345309
dc.identifier.pmid31011580
dc.identifier.scopus2-s2.0-85064087470
dc.identifier.fulltexthttps://smile.stomf.bg.ac.rs/bitstream/id/971/2438.pdf
dc.type.versionpublishedVersion


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