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Antibacterial effects of new endodontic materials based on calcium silicates
Antibakterijski efekti novih endodontskih materijala na bazi kalcijum silikata
dc.creator | Trišić, Dijana | |
dc.creator | Ćetenović, Bojana | |
dc.creator | Zdravković, Nemanja | |
dc.creator | Marković, Tatjana | |
dc.creator | Dojčinović, Biljana | |
dc.creator | Jokanović, Vukoman | |
dc.creator | Marković, Dejan | |
dc.date.accessioned | 2020-07-02T13:25:29Z | |
dc.date.available | 2020-07-02T13:25:29Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0042-8450 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/2444 | |
dc.description.abstract | Background/Aim. The main task of endodontic treatment is to eliminate pathologically altered tissue, to disinfect root canal space and to obtain its three-dimensional hermetic obturation. The main purpose of this study was to evaluate antimicrobial activity of new endodontic nano-structured highly active calcium silicates based materials albo-mineral plyoxide carbonate aggregate (ALBO-MPCA) and calcium silicates (CS) in comparison to mineral trioxide aggregate (MTA +) and UltraCal XS (CH). Methods. The antimicrobial activity of materials was tested against Staphylococcus aureus (ATCC 25923) and Entero-coccus faecalis (ATCC 14506) strains, and following clinical isolates: Rothia dentocariosa, Enterococcus faecalis, Staphylococcus aureus, Streptococcus anginosus and Streptococcus vestibularis using a double layer agar diffusion test. The pH measurements were performed using the pH meter. Total amount of released ions was determined by inductively coupled plasma optical emission spectrometry (ICP-OES). Results. All tested materials showed the best antibacterial potential after 1 h of incubation. After 3h and 24h of the incubation period, the an-tibacterial potential of all tested materials were similar. The Agar diffusion test showed that ALBO-MPCA, CS and MTA + had similar inhibition zones (p > 0.05), except in the activity against Staphylococcus aureus where ALBO-MPCA showed better antimicrobial properties than MTA + in 3h and 24h of the incubation period (p lt 0.05). Following 24h of the incubation, the inhibition zones were the strongest with CH against Staphylococcus aureus (16.67 ± 2.34 mm) followed by ALBO-MPCA (14.67 ± 1.21 mm) and the weakest with CS against Enterococcus faecalis (6.50 ± 1.76 mm). CH showed the highest pH, followed by ALBO-MPCA, CS and MTA +. Conclusion. The expressed antibacterial effects indicate that materials based on nano-structured highly active calcium silicates represent effective therapeutic agents for root canal obturation in one-visit apexification treatment, therefore they are recommend for further examination and clinical trials as they are proposed for MTA substitution. | en |
dc.description.abstract | Uvod/Cilj. Osnovni cilj endodonskog lečenja je eliminacija patološki izmenjenog tkiva, eliminacija infekcije korensko kanala i njegovo hermetičko trodimenzionalno zatvaranje. Cilj istraživanja je bio da se proceni antibakterijska aktivnost novih endodontskih nano-strukturiranih materijala na bazi visoko aktivnih kalcijum silikata albo-mineral polyoxide carbonate aggregate (ALBO-MPCA) i calcium silicates (CS) u odnosu na mineral trioxide aggregate (MTA +) i UltraCal XS (CH). Metode. Testirana je antibakterijska aktivnost materijala protiv Staphylococcus aureus (ATCC 25923) i Enterococcus faecalis (ATCC 14506), kao i kliničkih izolata: Rothia dentocariosa, Enterococcus faecalis, Staphylococcus aureus, Streptococcus anginosus i Streptococcus vestibularis pomoću agar difuzionog testa. Merenja pH vred-nosti obavljena su korišćenjem pH metra. Ukupan iznos oslobođenih jona određivan je pomoću ICP-OES. Rezultati. Svi testirani materijali pokazali su najbolji antibakterijski efekat nakon 1 h od inkubacije. Nakon 3 h i 24 h od inkubacije, antibakterijski efekat svih testiranih materijala bio je sličan. Agar difuzioni test pokazao je da materijali ALBOMPCA, CS i MTA+ ispoljavaju slične zone inhibicije rasta (p > 0.05) osim u slučaju Staphylococcus aureus, gde je materijal ALBO-MPCA pokazao bolje antibakterijsko dejstvo nego MTA+ nakon 3 h i 24 h od inkubacije (p lt 0.05). Nakon 24 h od inkubacije, zone inhibicije su bile najizraženije u slučaju materijala CS protiv Staphylococcus aureus (16.67 ± 2.34 mm), zatim ALBO-MPCA (14.67 ± 1.21 mm), a najslabije u slučaju CS protiv Enterococcus faecalis (6.50±1.76 mm). Materijal CH ispoljio je najveću pH vrednost, zatim ALBOMPCA, CS i MTA+. Zaključak. Ispoljeni antibakterijski efekti ukazuju na to da materijali na bazi visoko aktivnih kalcijum silikata mogu da predstavljaju efikasnu zamenu za MTA u terapiji zuba sa nezavršenim rastom korena u jednoj poseti, te se stoga preporučuju za dalja klinička ispitivanja | sr |
dc.publisher | Vojnomedicinska akademija - Institut za naučne informacije, Beograd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31079/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-sa/4.0/ | |
dc.source | Vojnosanitetski pregled | |
dc.subject | dental pulp diseases | en |
dc.subject | root canal preparation | en |
dc.subject | calcium silicate | en |
dc.subject | calcium hydroxide | en |
dc.subject | anti-infective agents | en |
dc.subject | zub, bolesti pulpe | sr |
dc.subject | zub, lečenje korenskog kanala | sr |
dc.subject | kalcijum silikat | sr |
dc.subject | kalcijum hidroksid | sr |
dc.subject | antiinfektivi | sr |
dc.title | Antibacterial effects of new endodontic materials based on calcium silicates | en |
dc.title | Antibakterijski efekti novih endodontskih materijala na bazi kalcijum silikata | sr |
dc.type | article | |
dc.rights.license | BY-SA | |
dcterms.abstract | Јокановић, Вукоман; Тришић, Дијана; Здравковић, Немања; Марковић, Дејан; Марковић, Татјана; Дојчиновић, Биљана; Ћетеновић, Бојана; Aнтибактеријски ефекти нових ендодонтских материјала на бази калцијум силиката; Aнтибактеријски ефекти нових ендодонтских материјала на бази калцијум силиката; | |
dc.citation.volume | 76 | |
dc.citation.issue | 4 | |
dc.citation.spage | 365 | |
dc.citation.epage | 372 | |
dc.citation.other | 76(4): 365-372 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000504432700002 | |
dc.identifier.doi | 10.2298/VSP161231130T | |
dc.identifier.scopus | 2-s2.0-85069738071 | |
dc.identifier.fulltext | https://smile.stomf.bg.ac.rs/bitstream/id/972/2439.pdf | |
dc.type.version | publishedVersion |