Notch signaling pathway mediates alveolar bone resorption in apical periodontitis
Само за регистроване кориснике
2019
Аутори
Jakovljević, Aleksandar
Miletić, Maja
Nikolić, Nadja

Beljić-Ivanović, Katarina
Andrić, Miroslav

Milašin, Jelena

Чланак у часопису (Објављена верзија)

Метаподаци
Приказ свих података о документуАпстракт
Apical periodontitis represents a chronic inflammatory process within periapical tissues, mostly caused by etiological agents of endodontic origin. Progressive bone resorption in the periapical region represents the hallmark of apical periodontitis and occurs as the consequence of interplay between polymicrobial infections and host response. The Notch signaling pathway is an evolutionary conserved cell-signaling system that plays an important role in a variety of cell functions including proliferation, differentiation and apoptosis. In recent years its involvement in bone homeostasis has attracted a significant consideration. We hypothesized that Notch signaling pathway, which has a complex interplay with proinflammatory cytokines and bone resorption regulators, contributes to alveolar bone resorption via increased Notch receptors on immune cell surface and stimulates Notch receptor intracellular domain (NICD) translocation into the nucleus. The potential benefit of medications aimed t...o down-regulate these pathways in apical periodontitis treatment remains to be assessed.
Извор:
Medical Hypotheses, 2019, 124, 87-90Издавач:
- Churchill Livingstone, Edinburgh
Финансирање / пројекти:
DOI: 10.1016/j.mehy.2019.02.018
ISSN: 0306-9877
PubMed: 30798925
WoS: 000461407900020
Scopus: 2-s2.0-85061062852
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Jakovljević, Aleksandar AU - Miletić, Maja AU - Nikolić, Nadja AU - Beljić-Ivanović, Katarina AU - Andrić, Miroslav AU - Milašin, Jelena PY - 2019 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2455 AB - Apical periodontitis represents a chronic inflammatory process within periapical tissues, mostly caused by etiological agents of endodontic origin. Progressive bone resorption in the periapical region represents the hallmark of apical periodontitis and occurs as the consequence of interplay between polymicrobial infections and host response. The Notch signaling pathway is an evolutionary conserved cell-signaling system that plays an important role in a variety of cell functions including proliferation, differentiation and apoptosis. In recent years its involvement in bone homeostasis has attracted a significant consideration. We hypothesized that Notch signaling pathway, which has a complex interplay with proinflammatory cytokines and bone resorption regulators, contributes to alveolar bone resorption via increased Notch receptors on immune cell surface and stimulates Notch receptor intracellular domain (NICD) translocation into the nucleus. The potential benefit of medications aimed to down-regulate these pathways in apical periodontitis treatment remains to be assessed. PB - Churchill Livingstone, Edinburgh T2 - Medical Hypotheses T1 - Notch signaling pathway mediates alveolar bone resorption in apical periodontitis VL - 124 SP - 87 EP - 90 DO - 10.1016/j.mehy.2019.02.018 ER -
@article{ author = "Jakovljević, Aleksandar and Miletić, Maja and Nikolić, Nadja and Beljić-Ivanović, Katarina and Andrić, Miroslav and Milašin, Jelena", year = "2019", abstract = "Apical periodontitis represents a chronic inflammatory process within periapical tissues, mostly caused by etiological agents of endodontic origin. Progressive bone resorption in the periapical region represents the hallmark of apical periodontitis and occurs as the consequence of interplay between polymicrobial infections and host response. The Notch signaling pathway is an evolutionary conserved cell-signaling system that plays an important role in a variety of cell functions including proliferation, differentiation and apoptosis. In recent years its involvement in bone homeostasis has attracted a significant consideration. We hypothesized that Notch signaling pathway, which has a complex interplay with proinflammatory cytokines and bone resorption regulators, contributes to alveolar bone resorption via increased Notch receptors on immune cell surface and stimulates Notch receptor intracellular domain (NICD) translocation into the nucleus. The potential benefit of medications aimed to down-regulate these pathways in apical periodontitis treatment remains to be assessed.", publisher = "Churchill Livingstone, Edinburgh", journal = "Medical Hypotheses", title = "Notch signaling pathway mediates alveolar bone resorption in apical periodontitis", volume = "124", pages = "87-90", doi = "10.1016/j.mehy.2019.02.018" }
Jakovljević, A., Miletić, M., Nikolić, N., Beljić-Ivanović, K., Andrić, M.,& Milašin, J.. (2019). Notch signaling pathway mediates alveolar bone resorption in apical periodontitis. in Medical Hypotheses Churchill Livingstone, Edinburgh., 124, 87-90. https://doi.org/10.1016/j.mehy.2019.02.018
Jakovljević A, Miletić M, Nikolić N, Beljić-Ivanović K, Andrić M, Milašin J. Notch signaling pathway mediates alveolar bone resorption in apical periodontitis. in Medical Hypotheses. 2019;124:87-90. doi:10.1016/j.mehy.2019.02.018 .
Jakovljević, Aleksandar, Miletić, Maja, Nikolić, Nadja, Beljić-Ivanović, Katarina, Andrić, Miroslav, Milašin, Jelena, "Notch signaling pathway mediates alveolar bone resorption in apical periodontitis" in Medical Hypotheses, 124 (2019):87-90, https://doi.org/10.1016/j.mehy.2019.02.018 . .