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dc.creatorVucetić, M.
dc.creatorRoganović, Jelena
dc.creatorFreilich, M.
dc.creatorShafer, D.
dc.creatorMilić, Marija
dc.creatorĐukić, Ljiljana
dc.creatorPetrović, Nina
dc.creatorMarković, Evgenija
dc.creatorMarković, Aleksa
dc.creatorBrković, Božidar
dc.date.accessioned2020-07-02T13:27:49Z
dc.date.available2020-07-02T13:27:49Z
dc.date.issued2020
dc.identifier.issn1432-6981
dc.identifier.urihttp://smile.stomf.bg.ac.rs/handle/123456789/2481
dc.description.abstractObjective: To evaluate an association between bone levels of inflammation/oxidative stress mediators and postoperative discomfort after third molar conventional or piezosurgery. Material and methods: Twenty-six subjects with bilaterally impacted mandibular third molars, who underwent either piezo or conventional surgery, were included in a split-mouth design study. MicroRNA-21 (miR-21) expression, interleukin-1 beta (IL-1β), and vascular endothelial growth factor (VEGF) proteins, as well as superoxide dismutase (SOD) activity in alveolar bone, were evaluated. Pain intensity, the first pain appearance, analgesic first use and total dose taken, trismus, and swelling were clinically recorded. Results: MiR-21 expression was higher while VEGF protein was lower in piezosurgery vs. conventional groups. The differences in IL-1β protein and SOD activity were not significant between groups. The pain intensity on the first day was significantly decreased in piezosurgery group. The first pain appearance and the first analgesic taken were reported sooner in conventional vs. piezosurgical group. Significantly pronounced trismus on the third day following conventional surgery was found. In conventional group, significantly increased trismus was observed on the third compared to the first postoperative day. MiR-21 showed significant correlation with the first pain appearance. Conclusion: Delayed onset of less pronounced postoperative pain after piezosurgical vs. conventional extraction of impacted lower third molar was significantly associated with expression of bone miR-21. Clinical relevance: Alveolar bone miR-21 may reflect surgical stress and is associated with third molar postoperative pain onset.en
dc.publisherSpringer
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175021/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Oral Investigations
dc.subjectIL-1βen
dc.subjectLower third molaren
dc.subjectmiR-21en
dc.subjectPiezoen
dc.subjectSODen
dc.subjectVEGFen
dc.titleBone microRNA-21 as surgical stress parameter is associated with third molar postoperative discomforten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМарковић, Евгенија; Вуцетић, М.; Петровић, Нина; Марковић, Aлекса; Рогановић, Јелена; Милић, Марија; Ђукић, Љиљана; Схафер, Д.; Фреилицх, М.; Брковић, Божидар;
dc.citation.rankM21~
dc.identifier.wos000538665700001
dc.identifier.doi10.1007/s00784-020-03366-6
dc.identifier.scopus2-s2.0-85085882257
dc.identifier.rcubconv_3881
dc.type.versionpublishedVersion


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