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dc.creatorMijailović, Iva
dc.creatorNikolić, Nadja
dc.creatorĐinić, Ana
dc.creatorČarkić, Jelena
dc.creatorMilinković, Iva
dc.creatorPerić, Mina
dc.creatorJanković, Saša
dc.creatorMilašin, Jelena
dc.creatorAleksić, Zoran
dc.date.accessioned2020-07-02T13:28:30Z
dc.date.available2020-07-02T13:28:30Z
dc.date.issued2020
dc.identifier.issn0022-3492
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/2492
dc.description.abstractBackground The exact mechanisms of bone resorption in periodontitis have not been fully elucidated. The aims of this study were to analyze the expression of Notch signaling molecules, bone remodeling mediators, and pro-inflammatory cytokines in periodontitis patients and to determine their potential correlations. Methods The study included 130 individuals: 40 with aggressive periodontitis (AP group), 40 with chronic periodontitis (CP group), and 50 periodontally healthy controls. Total RNA was extracted from gingival crevicular fluid samples and relative gene expression of investigated molecules (Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1, TNF-alpha, IL-17, RANKL, and OPG) was determined by reverse transcriptase - real-time polymerase chain reaction (RT-qPCR). Results In AP group, a significant increase of Notch 2, TNF-alpha, IL-17 and RANKL and a significant decrease of Notch 1 and Jagged 1 expression were observed compared to control group (P = 0.023, P = 0.005, P = 0.030, and P = 0.001 P = 0.031 and P = 0.029, respectively). Notch 2 and RANKL were also overexpressed in CP group compared to controls (P = 0.001 and P = 0.011). Significant correlations were observed in AP group between expression levels of the analyzed genes. Conclusion The present findings implicate Notch 2 overexpression in the ethiopathogenesis of bone resorption in aggressive and chronic periodontitis. The down-regulation of Notch 1 and Jagged 1 and loss of their osteoprotective function might cause a more excessive osteoclast formation and contribute to greater osteolysis in aggressive periodontitis.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41008/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Periodontology
dc.subjectaggressive periodontitisen
dc.subjectbone remodelingen
dc.subjectgene expressionen
dc.subjectperiodontitisen
dc.titleThe down-regulation of Notch 1 signaling contributes to the severity of bone loss in aggressive periodontitisen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНиколић, Нађа; Милашин, Јелена; Ђинић, Aна; Перић, Мина; Aлексић, Зоран; Јанковић, Саша; Мијаиловић, Ива; Чаркић, Јелена; Милинковић, Ива;
dc.citation.volume91
dc.citation.issue4
dc.citation.spage554
dc.citation.epage561
dc.citation.other91(4): 554-561
dc.citation.rankaM21~
dc.identifier.wos000489221100001
dc.identifier.doi10.1002/JPER.18-0755
dc.identifier.pmid31468527
dc.identifier.scopus2-s2.0-85084167989
dc.type.versionpublishedVersion


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