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dc.creatorĐinić Krasavčević, Ana
dc.creatorNikolić, Nadja
dc.creatorMijailović, Iva
dc.creatorČarkić, Jelena
dc.creatorMilinković, Iva
dc.creatorJanković, Saša
dc.creatorAleksić, Zoran
dc.creatorMilašin, Jelena
dc.date.accessioned2021-03-29T21:48:46Z
dc.date.available2021-03-29T21:48:46Z
dc.date.issued2021
dc.identifier.issn0022-3484
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/2568
dc.description.abstractBackground and objective Notch signalling cascade has recently been connected to alveolar bone resorption in periodontitis. Hence, the present cross‐sectional study aimed to analyze the expression of Notch signalling pathway (Notch 1, Notch 2, Jagged 1, Hes 1, Hey 1) and periodontitis‐related (tumor necrosis factor alpha‐ TNF‐α, interleukin 17‐IL‐17, receptor activator of nuclear factor‐kappa B ligand—RANKL, osteoprotegerin—OPG) molecules and correlate it with clinical parameters in aggressive (AP) and chronic (CP) periodontitis. Additionally, the aforementioned markers' expression was evaluated in periodontitis patients with different RANKL/OPG ratios. Material and methods Eighty patients were enrolled either in AP or CP group. Clinical attachment level (CAL), bleeding on probing (BOP), periodontal probing depth (PPD) and plaque index (PI) were recorded for each patient. Total RNA was extracted from gingival crevicular fluid samples. Relative gene expression of investigated markers was determined by reverse transcriptase‐real‐time polymerase chain reaction. Results Significantly higher values of PPD were observed in AP compared to CP (P = .010). Negative correlations between OPG and CAL, and OPG and PI, were found in AP (P = .045, P = .006, respectively), while Hey 1 and PI had a positive correlation (P = .049). In multivariate linear regression analysis, OPG and Notch 2 were predictors of CAL in AP group. TNF‐α and IL‐17 were higher in RANKL predominant than in OPG predominant cases (P = .007, P = .001, respectively). In RANKL predominant lesions Notch 1 and Jagged 1 were down‐regulated in AP compared to CP patients (P = .010, P = .025, respectively). Conclusion The present study demonstrated that changes in Notch 2 expression affected CAL in AP cases hence this molecule could be considered as a contributor to alveolar bone loss. In RANKL‐activated settings, the down‐regulation of Notch 1 might participate in more severe bone resorption in AP.sr
dc.language.isoensr
dc.publisherWileysr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS//sr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41008/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceJournal of Periodontal Researchsr
dc.subjectNotch signallingsr
dc.subjectaggressive periodontitissr
dc.subjectclinical parameterssr
dc.subjectgene expressionsr
dc.titleImpact of Notch signalling molecules and bone resorption regulators on clinical parameters in periodontitissr
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractЈанковић, Саша; Чаркић, Јелена; Мијаиловић, Ива; Милашин, Јелена; Милинковић, Ива; Aлексић, Зоран; Ђинић Красавчевић, Aна; Николић, Надја; Импацт оф Нотцх сигналлинг молецулес анд боне ресорптион регулаторс он цлиницал параметерс ин периодонтитис; Импацт оф Нотцх сигналлинг молецулес анд боне ресорптион регулаторс он цлиницал параметерс ин периодонтитис;
dc.citation.volume56
dc.citation.issue1
dc.citation.spage131
dc.citation.epage138
dc.identifier.wos000569482200001
dc.identifier.doi10.1111/jre.12801
dc.identifier.pmid32936934
dc.identifier.scopus2-s2.0-85090968961
dc.type.versionpublishedVersionsr


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