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VAL158MET catechol O-methyltransferase polymorphism contributes to the development of preeclampsia
dc.creator | Šljivančanin Jakovljević, Tamara | |
dc.creator | Kontić-Vučinić, Olivera | |
dc.creator | Nikolić, Nadja | |
dc.creator | Čarkić, Jelena | |
dc.creator | Milašin, Jelena | |
dc.date.accessioned | 2021-03-30T05:50:27Z | |
dc.date.available | 2021-03-30T05:50:27Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1064-1955 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/2572 | |
dc.description.abstract | Objectives: Establishment of association between: (a) Val158Met COMT (G1947A) polymorphism and preeclampsia; (b) cytokines gene expression and COMT genotypes. Methods: 50 preeclampsia and 50 healthy pregnant women were enrolled. COMT genotyping was done by PCR/RFLP. TNF-α, IL-1β, and IL-6 mRNA levels were determined by Real-time PCR. Results: Variant (AA) homozygotes carried 3.7-fold increased preeclampsia odds, especially for severe (OR = 9.0, 95%CI (2.09-38.799)) and early forms (OR = 6.6, 95%CI (1.62-26.87)). AA homozygotes with PE had higher TNF-α levels compared to controls (P = 0.012). Conclusions: Val158Met COMT polymorphism increases preeclampsia risk. TNF-α expression and Val158Met COMT polymorphism have concomitant roles in PE pathogenesis. | sr |
dc.language.iso | en | sr |
dc.publisher | Taylor & Francis Inc. | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Hypertension in Pregnancy | sr |
dc.subject | Pre-eclampsia | sr |
dc.subject | catechol O-methyltransferase | sr |
dc.subject | cytokines | sr |
dc.subject | polymorphism | sr |
dc.title | VAL158MET catechol O-methyltransferase polymorphism contributes to the development of preeclampsia | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Контић-Вучинић, Оливера; Чаркић, Јелена; Милашин, Јелена; Шљиванчанин Јаковљевић, Тамара; Николић, Надја; | |
dc.citation.volume | 39 | |
dc.citation.issue | 4 | |
dc.citation.spage | 471 | |
dc.citation.epage | 480 | |
dc.identifier.wos | 000586918500001 | |
dc.identifier.doi | 10.1080/10641955.2020.1843663 | |
dc.identifier.pmid | 33155880 | |
dc.identifier.scopus | 2-s2.0-85095822671 | |
dc.type.version | publishedVersion | sr |