Association between cardiovascular diseases and apical periodontitis: an umbrella review
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2020
Authors
Jakovljević, Aleksandar
Duncan, Henry F.

Nagendrababu, Venkateshbabu

Jaćimović, Jelena

Milašin, Jelena

Dummer, Paul

Article (Published version)

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Background: The existence of an association between cardiovascular diseases (CVDs) and apical periodontitis (AP) remains unclear because results obtained from previous clinical studies and reviews are inconsistent or inconclusive.
Objective: To conduct an umbrella review to determine whether there is an association between CVDs and the prevalence of AP in adults.
Methods: The protocol of the review was registered in the PROSPERO database (CRD42020185753). The literature search was conducted using the following electronic databases: Clarivate Analytics' Web of Science Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to May, 2020, with no language restrictions. Systematic reviews with or without meta-analysis that evaluated the association between CVDs and AP were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction and quality assessment of included studies.... Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews), with 16 items. A final categorization of the systematic reviews classified each as of 'high', 'moderate', 'low' or 'critically low' quality.
Results: Four systematic reviews were included in the current review. Three reviews were graded by AMSTAR 2 as 'moderate' quality, whereas one review was graded as 'critically low' quality.
Discussion: Only one systematic review included a meta-analysis. Substantial heterogeneity amongst the primary studies included within each systematic review was notable in preventing a pooled analysis.
Conclusions: From the limited 'moderate' to 'critically low' quality evidence available, the current umbrella review concluded that a weak association exists between CVDs and AP. In the future, well-designed, longitudinal clinical studies with long-term follow-up are required.
Keywords:
apical periodontitis / cardiovascular disease / meta-analysis / systematic review / umbrella reviewSource:
International Endodontic Journal, 2020, 53, 10, 1374-1386Publisher:
- Wiley
Funding / projects:
DOI: 10.1111/iej.13364
ISSN: 0143-2885
PubMed: 32648971
WoS: 000557009500001
Scopus: 2-s2.0-85089092359
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Stomatološki fakultetTY - JOUR AU - Jakovljević, Aleksandar AU - Duncan, Henry F. AU - Nagendrababu, Venkateshbabu AU - Jaćimović, Jelena AU - Milašin, Jelena AU - Dummer, Paul PY - 2020 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2573 AB - Background: The existence of an association between cardiovascular diseases (CVDs) and apical periodontitis (AP) remains unclear because results obtained from previous clinical studies and reviews are inconsistent or inconclusive. Objective: To conduct an umbrella review to determine whether there is an association between CVDs and the prevalence of AP in adults. Methods: The protocol of the review was registered in the PROSPERO database (CRD42020185753). The literature search was conducted using the following electronic databases: Clarivate Analytics' Web of Science Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to May, 2020, with no language restrictions. Systematic reviews with or without meta-analysis that evaluated the association between CVDs and AP were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction and quality assessment of included studies. Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews), with 16 items. A final categorization of the systematic reviews classified each as of 'high', 'moderate', 'low' or 'critically low' quality. Results: Four systematic reviews were included in the current review. Three reviews were graded by AMSTAR 2 as 'moderate' quality, whereas one review was graded as 'critically low' quality. Discussion: Only one systematic review included a meta-analysis. Substantial heterogeneity amongst the primary studies included within each systematic review was notable in preventing a pooled analysis. Conclusions: From the limited 'moderate' to 'critically low' quality evidence available, the current umbrella review concluded that a weak association exists between CVDs and AP. In the future, well-designed, longitudinal clinical studies with long-term follow-up are required. PB - Wiley T2 - International Endodontic Journal T1 - Association between cardiovascular diseases and apical periodontitis: an umbrella review VL - 53 IS - 10 SP - 1374 EP - 1386 DO - 10.1111/iej.13364 ER -
@article{ author = "Jakovljević, Aleksandar and Duncan, Henry F. and Nagendrababu, Venkateshbabu and Jaćimović, Jelena and Milašin, Jelena and Dummer, Paul", year = "2020", abstract = "Background: The existence of an association between cardiovascular diseases (CVDs) and apical periodontitis (AP) remains unclear because results obtained from previous clinical studies and reviews are inconsistent or inconclusive. Objective: To conduct an umbrella review to determine whether there is an association between CVDs and the prevalence of AP in adults. Methods: The protocol of the review was registered in the PROSPERO database (CRD42020185753). The literature search was conducted using the following electronic databases: Clarivate Analytics' Web of Science Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to May, 2020, with no language restrictions. Systematic reviews with or without meta-analysis that evaluated the association between CVDs and AP were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction and quality assessment of included studies. Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews), with 16 items. A final categorization of the systematic reviews classified each as of 'high', 'moderate', 'low' or 'critically low' quality. Results: Four systematic reviews were included in the current review. Three reviews were graded by AMSTAR 2 as 'moderate' quality, whereas one review was graded as 'critically low' quality. Discussion: Only one systematic review included a meta-analysis. Substantial heterogeneity amongst the primary studies included within each systematic review was notable in preventing a pooled analysis. Conclusions: From the limited 'moderate' to 'critically low' quality evidence available, the current umbrella review concluded that a weak association exists between CVDs and AP. In the future, well-designed, longitudinal clinical studies with long-term follow-up are required.", publisher = "Wiley", journal = "International Endodontic Journal", title = "Association between cardiovascular diseases and apical periodontitis: an umbrella review", volume = "53", number = "10", pages = "1374-1386", doi = "10.1111/iej.13364" }
Jakovljević, A., Duncan, H. F., Nagendrababu, V., Jaćimović, J., Milašin, J.,& Dummer, P.. (2020). Association between cardiovascular diseases and apical periodontitis: an umbrella review. in International Endodontic Journal Wiley., 53(10), 1374-1386. https://doi.org/10.1111/iej.13364
Jakovljević A, Duncan HF, Nagendrababu V, Jaćimović J, Milašin J, Dummer P. Association between cardiovascular diseases and apical periodontitis: an umbrella review. in International Endodontic Journal. 2020;53(10):1374-1386. doi:10.1111/iej.13364 .
Jakovljević, Aleksandar, Duncan, Henry F., Nagendrababu, Venkateshbabu, Jaćimović, Jelena, Milašin, Jelena, Dummer, Paul, "Association between cardiovascular diseases and apical periodontitis: an umbrella review" in International Endodontic Journal, 53, no. 10 (2020):1374-1386, https://doi.org/10.1111/iej.13364 . .