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Association between cardiovascular diseases and apical periodontitis: an umbrella review

Authorized Users Only
2020
Authors
Jakovljević, Aleksandar
Duncan, Henry F.
Nagendrababu, Venkateshbabu
Jaćimović, Jelena
Milašin, Jelena
Dummer, Paul
Article (Published version)
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Abstract
Background: The existence of an association between cardiovascular diseases (CVDs) and apical periodontitis (AP) remains unclear because results obtained from previous clinical studies and reviews are inconsistent or inconclusive. Objective: To conduct an umbrella review to determine whether there is an association between CVDs and the prevalence of AP in adults. Methods: The protocol of the review was registered in the PROSPERO database (CRD42020185753). The literature search was conducted using the following electronic databases: Clarivate Analytics' Web of Science Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to May, 2020, with no language restrictions. Systematic reviews with or without meta-analysis that evaluated the association between CVDs and AP were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction and quality assessment of included studies.... Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews), with 16 items. A final categorization of the systematic reviews classified each as of 'high', 'moderate', 'low' or 'critically low' quality. Results: Four systematic reviews were included in the current review. Three reviews were graded by AMSTAR 2 as 'moderate' quality, whereas one review was graded as 'critically low' quality. Discussion: Only one systematic review included a meta-analysis. Substantial heterogeneity amongst the primary studies included within each systematic review was notable in preventing a pooled analysis. Conclusions: From the limited 'moderate' to 'critically low' quality evidence available, the current umbrella review concluded that a weak association exists between CVDs and AP. In the future, well-designed, longitudinal clinical studies with long-term follow-up are required.

Keywords:
apical periodontitis / cardiovascular disease / meta-analysis / systematic review / umbrella review
Source:
International Endodontic Journal, 2020, 53, 10, 1374-1386
Publisher:
  • Wiley
Funding / projects:
  • Genetic control and molecular mechanisms in malignant, inflammatory and developmental pathologies of the orofacial region (RS-175075)

DOI: 10.1111/iej.13364

ISSN: 0143-2885

PubMed: 32648971

WoS: 000557009500001

Scopus: 2-s2.0-85089092359
[ Google Scholar ]
27
10
URI
https://smile.stomf.bg.ac.rs/handle/123456789/2573
Collections
  • Radovi istraživača
Institution/Community
Stomatološki fakultet
TY  - JOUR
AU  - Jakovljević, Aleksandar
AU  - Duncan, Henry F.
AU  - Nagendrababu, Venkateshbabu
AU  - Jaćimović, Jelena
AU  - Milašin, Jelena
AU  - Dummer, Paul
PY  - 2020
UR  - https://smile.stomf.bg.ac.rs/handle/123456789/2573
AB  - Background: The existence of an association between cardiovascular diseases (CVDs) and apical periodontitis (AP) remains unclear because results obtained from previous clinical studies and reviews are inconsistent or inconclusive.

Objective: To conduct an umbrella review to determine whether there is an association between CVDs and the prevalence of AP in adults.

Methods: The protocol of the review was registered in the PROSPERO database (CRD42020185753). The literature search was conducted using the following electronic databases: Clarivate Analytics' Web of Science Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to May, 2020, with no language restrictions. Systematic reviews with or without meta-analysis that evaluated the association between CVDs and AP were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction and quality assessment of included studies. Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews), with 16 items. A final categorization of the systematic reviews classified each as of 'high', 'moderate', 'low' or 'critically low' quality.

Results: Four systematic reviews were included in the current review. Three reviews were graded by AMSTAR 2 as 'moderate' quality, whereas one review was graded as 'critically low' quality.

Discussion: Only one systematic review included a meta-analysis. Substantial heterogeneity amongst the primary studies included within each systematic review was notable in preventing a pooled analysis.

Conclusions: From the limited 'moderate' to 'critically low' quality evidence available, the current umbrella review concluded that a weak association exists between CVDs and AP. In the future, well-designed, longitudinal clinical studies with long-term follow-up are required.
PB  - Wiley
T2  - International Endodontic Journal
T1  - Association between cardiovascular diseases and apical periodontitis: an umbrella review
VL  - 53
IS  - 10
SP  - 1374
EP  - 1386
DO  - 10.1111/iej.13364
ER  - 
@article{
author = "Jakovljević, Aleksandar and Duncan, Henry F. and Nagendrababu, Venkateshbabu and Jaćimović, Jelena and Milašin, Jelena and Dummer, Paul",
year = "2020",
abstract = "Background: The existence of an association between cardiovascular diseases (CVDs) and apical periodontitis (AP) remains unclear because results obtained from previous clinical studies and reviews are inconsistent or inconclusive.

Objective: To conduct an umbrella review to determine whether there is an association between CVDs and the prevalence of AP in adults.

Methods: The protocol of the review was registered in the PROSPERO database (CRD42020185753). The literature search was conducted using the following electronic databases: Clarivate Analytics' Web of Science Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to May, 2020, with no language restrictions. Systematic reviews with or without meta-analysis that evaluated the association between CVDs and AP were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction and quality assessment of included studies. Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews), with 16 items. A final categorization of the systematic reviews classified each as of 'high', 'moderate', 'low' or 'critically low' quality.

Results: Four systematic reviews were included in the current review. Three reviews were graded by AMSTAR 2 as 'moderate' quality, whereas one review was graded as 'critically low' quality.

Discussion: Only one systematic review included a meta-analysis. Substantial heterogeneity amongst the primary studies included within each systematic review was notable in preventing a pooled analysis.

Conclusions: From the limited 'moderate' to 'critically low' quality evidence available, the current umbrella review concluded that a weak association exists between CVDs and AP. In the future, well-designed, longitudinal clinical studies with long-term follow-up are required.",
publisher = "Wiley",
journal = "International Endodontic Journal",
title = "Association between cardiovascular diseases and apical periodontitis: an umbrella review",
volume = "53",
number = "10",
pages = "1374-1386",
doi = "10.1111/iej.13364"
}
Jakovljević, A., Duncan, H. F., Nagendrababu, V., Jaćimović, J., Milašin, J.,& Dummer, P.. (2020). Association between cardiovascular diseases and apical periodontitis: an umbrella review. in International Endodontic Journal
Wiley., 53(10), 1374-1386.
https://doi.org/10.1111/iej.13364
Jakovljević A, Duncan HF, Nagendrababu V, Jaćimović J, Milašin J, Dummer P. Association between cardiovascular diseases and apical periodontitis: an umbrella review. in International Endodontic Journal. 2020;53(10):1374-1386.
doi:10.1111/iej.13364 .
Jakovljević, Aleksandar, Duncan, Henry F., Nagendrababu, Venkateshbabu, Jaćimović, Jelena, Milašin, Jelena, Dummer, Paul, "Association between cardiovascular diseases and apical periodontitis: an umbrella review" in International Endodontic Journal, 53, no. 10 (2020):1374-1386,
https://doi.org/10.1111/iej.13364 . .

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