Background: The existence of an association between cardiovascular diseases (CVDs) and apical periodontitis (AP) remains unclear because results obtained from previous clinical studies and reviews are inconsistent or inconclusive.
Objective: To conduct an umbrella review to determine whether there is an association between CVDs and the prevalence of AP in adults.
Methods: The protocol of the review was registered in the PROSPERO database (CRD42020185753). The literature search was conducted using the following electronic databases: Clarivate Analytics' Web of Science Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to May, 2020, with no language restrictions. Systematic reviews with or without meta-analysis that evaluated the association between CVDs and AP were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction and quality assessment of included studies.... Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews), with 16 items. A final categorization of the systematic reviews classified each as of 'high', 'moderate', 'low' or 'critically low' quality.
Results: Four systematic reviews were included in the current review. Three reviews were graded by AMSTAR 2 as 'moderate' quality, whereas one review was graded as 'critically low' quality.
Discussion: Only one systematic review included a meta-analysis. Substantial heterogeneity amongst the primary studies included within each systematic review was notable in preventing a pooled analysis.
Conclusions: From the limited 'moderate' to 'critically low' quality evidence available, the current umbrella review concluded that a weak association exists between CVDs and AP. In the future, well-designed, longitudinal clinical studies with long-term follow-up are required.
TY - JOUR
AU - Jakovljević, Aleksandar
AU - Duncan, Henry F.
AU - Nagendrababu, Venkateshbabu
AU - Jaćimović, Jelena
AU - Milašin, Jelena
AU - Dummer, Paul
PY - 2020
UR - https://smile.stomf.bg.ac.rs/handle/123456789/2573
AB - Background: The existence of an association between cardiovascular diseases (CVDs) and apical periodontitis (AP) remains unclear because results obtained from previous clinical studies and reviews are inconsistent or inconclusive.
Objective: To conduct an umbrella review to determine whether there is an association between CVDs and the prevalence of AP in adults.
Methods: The protocol of the review was registered in the PROSPERO database (CRD42020185753). The literature search was conducted using the following electronic databases: Clarivate Analytics' Web of Science Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to May, 2020, with no language restrictions. Systematic reviews with or without meta-analysis that evaluated the association between CVDs and AP were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction and quality assessment of included studies. Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews), with 16 items. A final categorization of the systematic reviews classified each as of 'high', 'moderate', 'low' or 'critically low' quality.
Results: Four systematic reviews were included in the current review. Three reviews were graded by AMSTAR 2 as 'moderate' quality, whereas one review was graded as 'critically low' quality.
Discussion: Only one systematic review included a meta-analysis. Substantial heterogeneity amongst the primary studies included within each systematic review was notable in preventing a pooled analysis.
Conclusions: From the limited 'moderate' to 'critically low' quality evidence available, the current umbrella review concluded that a weak association exists between CVDs and AP. In the future, well-designed, longitudinal clinical studies with long-term follow-up are required.
PB - Wiley
T2 - International Endodontic Journal
T1 - Association between cardiovascular diseases and apical periodontitis: an umbrella review
VL - 53
IS - 10
SP - 1374
EP - 1386
DO - 10.1111/iej.13364
ER -
@article{
author = "Jakovljević, Aleksandar and Duncan, Henry F. and Nagendrababu, Venkateshbabu and Jaćimović, Jelena and Milašin, Jelena and Dummer, Paul",
year = "2020",
abstract = "Background: The existence of an association between cardiovascular diseases (CVDs) and apical periodontitis (AP) remains unclear because results obtained from previous clinical studies and reviews are inconsistent or inconclusive.
Objective: To conduct an umbrella review to determine whether there is an association between CVDs and the prevalence of AP in adults.
Methods: The protocol of the review was registered in the PROSPERO database (CRD42020185753). The literature search was conducted using the following electronic databases: Clarivate Analytics' Web of Science Scopus, PubMed and Cochrane Database of Systematic Reviews, from inception to May, 2020, with no language restrictions. Systematic reviews with or without meta-analysis that evaluated the association between CVDs and AP were included. Other types of studies, including narrative reviews, were excluded. Two reviewers independently performed a literature search, data extraction and quality assessment of included studies. Any disagreements or doubts were resolved by a third reviewer. The quality of the reviews was assessed using the AMSTAR 2 tool (A measurement tool to assess systematic reviews), with 16 items. A final categorization of the systematic reviews classified each as of 'high', 'moderate', 'low' or 'critically low' quality.
Results: Four systematic reviews were included in the current review. Three reviews were graded by AMSTAR 2 as 'moderate' quality, whereas one review was graded as 'critically low' quality.
Discussion: Only one systematic review included a meta-analysis. Substantial heterogeneity amongst the primary studies included within each systematic review was notable in preventing a pooled analysis.
Conclusions: From the limited 'moderate' to 'critically low' quality evidence available, the current umbrella review concluded that a weak association exists between CVDs and AP. In the future, well-designed, longitudinal clinical studies with long-term follow-up are required.",
publisher = "Wiley",
journal = "International Endodontic Journal",
title = "Association between cardiovascular diseases and apical periodontitis: an umbrella review",
volume = "53",
number = "10",
pages = "1374-1386",
doi = "10.1111/iej.13364"
}
Jakovljević, A., Duncan, H. F., Nagendrababu, V., Jaćimović, J., Milašin, J.,& Dummer, P.. (2020). Association between cardiovascular diseases and apical periodontitis: an umbrella review. in International Endodontic Journal
Wiley., 53(10), 1374-1386.
https://doi.org/10.1111/iej.13364
Jakovljević A, Duncan HF, Nagendrababu V, Jaćimović J, Milašin J, Dummer P. Association between cardiovascular diseases and apical periodontitis: an umbrella review. in International Endodontic Journal. 2020;53(10):1374-1386.
doi:10.1111/iej.13364 .
Jakovljević, Aleksandar, Duncan, Henry F., Nagendrababu, Venkateshbabu, Jaćimović, Jelena, Milašin, Jelena, Dummer, Paul, "Association between cardiovascular diseases and apical periodontitis: an umbrella review" in International Endodontic Journal, 53, no. 10 (2020):1374-1386,
https://doi.org/10.1111/iej.13364 . .
