Приказ основних података о документу
MicroRNA-146a and -155, upregulated by periodontitis and type 2 diabetes in oral fluids, are predicted to regulate SARS-CoV-2 oral receptors genes
dc.creator | Roganović, Jelena | |
dc.date.accessioned | 2021-04-27T14:59:56Z | |
dc.date.available | 2021-04-27T14:59:56Z | |
dc.date.issued | 2020-12 | |
dc.identifier.issn | 0022-3492 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/2587 | |
dc.description.abstract | Background: Type 2 diabetes and periodontitis predispose to a higher risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Recent studies show upregulation of innate immuno-regulatory microRNA-146a and -155 in oral fluids of patients with type 2 diabetes as well as of patients with periodontitis. The aim was to investigate whether upregulation of these microRNAs may relate to patient susceptibility to the infection via modulation of SARS-CoV-2 cellular entry factors expression. Methods: Due to limited experimental feasibility and health risks in Coronavirus Disease 2019, bioinformatic analyses combining with system biology were used as initial investigation of interaction between microRNA-146 and -155 and genes encoding SARS-CoV-2 entry factors. Results: SARS-CoV-2 cellular entry factors are expressed in salivary glands and masticatory mucosa (tongue) at different expression levels, comparable with those measured in lungs and tonsil. MicroRNA-146 and -155 are widely involved in the regulation of SARS-CoV-2 oral cellular entry factors and may enhance expression of ACE2 and modulate genes involved in host immunity. Conclusions: Diabetes- and periodontitis-induced increase in microRNA-146a and -155 in oral cavity is predicted to upregulate angiotensin-converting enzyme 2 expression, essential SARS-CoV-2 entry receptors, and modulate host antiviral response. As it could suggest increased infectivity of diabetes and periodontitis patients, additional protective measures for periodontists are recommended. | sr |
dc.language.iso | en | sr |
dc.publisher | American Academy of Periodontology | sr |
dc.publisher | John Wiley & Sons, Inc. | sr |
dc.rights | openAccess | sr |
dc.source | Journal of Periodontology | sr |
dc.subject | microRNAs | sr |
dc.subject | periodontitis | sr |
dc.subject | SARS-CoV-2 | sr |
dc.subject | type 2 diabetes | sr |
dc.title | MicroRNA-146a and -155, upregulated by periodontitis and type 2 diabetes in oral fluids, are predicted to regulate SARS-CoV-2 oral receptors genes | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Рогановић, Јелена; | |
dc.rights.holder | © 2020 American Academy of Periodontology | sr |
dc.citation.rank | aM21 | |
dc.identifier.wos | 000606942900001 | |
dc.identifier.doi | 10.1002/JPER.20-0623 | |
dc.identifier.pmid | 33336412 | |
dc.identifier.scopus | 2-s2.0-85099227230 | |
dc.identifier.fulltext | http://smile.stomf.bg.ac.rs/bitstream/id/6156/JPER.20-0623 (1).pdf | |
dc.type.version | publishedVersion | sr |