Приказ основних података о документу
The diabetic dental pulp repair: involvement of vascular endothelial growth factor and bone morphogenetic protein 2
Reparacija dijabetične zubne pulpe – uloga vaskularnog endotelnog faktora rasta i kostnog morfogenetskog proteina 2
dc.creator | Ilić, Jugoslav | |
dc.creator | Radović, Katarina | |
dc.creator | Brković, Božidar | |
dc.creator | Vasić, Jugoslav | |
dc.creator | Roganović, Jelena | |
dc.date.accessioned | 2021-04-27T15:00:14Z | |
dc.date.available | 2021-04-27T15:00:14Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0370-8179 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/2588 | |
dc.description.abstract | Introduction/Objective. We aimed to investigate the effects of diabetes mellitus (DM) on rat dental pulp repair by measuring time-dependent changes in expressions of vascular endothelial growth factor (VEGF) and bone morphogenetic protein 2 (BMP 2) following direct pulp capping. Methods. Two groups, each of 20 Wistar rats, received either streptozotocin (for DM induction) or the same volume of sterile saline. A week later, the pulp of maxillary and mandibular right incisors in diabetic and non-diabetic groups were exposed and capped with calcium hydroxide in order to provoke reparative response. The levels of VEGF and BMP 2 were determined in the pulp tissue lysates one and seven days after the pulp capping, using enzyme-linked immunosorbent assays. Results. Diabetic state per se increased VEGF level, with a peak at first day after the pulp capping (19.3 ± 0.9 pg/mg, p < 0.001), but did not affect BMP 2 levels. Significant increase of BMP 2 expression was noticed on the seventh day in capped pulp, but only in diabetic rats (16.7 ± 1 pg/mg, p = 0.001). Positive correlation between VEGF and BMP 2 was found on the seventh day following capping, only in diabetic pulp (r = 0.905, p = 0.003). Conclusion. Diabetes-induced increase in VEGF expression reflects changes in the inflammatory phase of pulp repair in DM. Increase in BMP 2 expression suggest that stimulating effect of calcium hydroxide appears seven days after diabetic pulp capping. | sr |
dc.description.abstract | Uvod/Cilj Cilj ove studije bio je da se ispita efekat dijabetesa melitusa na reparaciju zubne pulpe pacova utvrđivanjem vremenski zavisnih promena u ekspresiji vaskularnog endotelnog faktora rasta (VEGF) i kostnog morfogenetskog proteina 2 (BMP 2) posle direktnog prekrivanja pulpe. Metode Istraživanje je sprovedeno na pacovima soja vistar, podeljenim u dve grupe od po 20 životinja, pri čemu je jedna grupa dobila streptozotocin (za indukciju dijabetesa melitusa), a druga sterilni fiziološki rastvor u istoj zapremini. Posle nedelju dana pulpe maksilarnih i mandibularnih donjih inciziva kod dijabetičnih i nedijabetičnih životinja su eksponirane i odmah zatim prekrivene kalcijum-hidroksidom da bi se izazvao reparatorni odgovor. Nivoi VEGF i BMP 2 su utvrđivani u lizatima pulpnog tkiva, prvog i sedmog dana posle direktnog prekrivanja imunoenzimskim testom ELISA. Rezultati Dijabetično stanje je dovelo do rasta nivoa VEGF, sa maksimumom utvrđenim prvog dana posle prekrivanja pulpe (19,3 ± 0,9 pg/mg, p < 0,001), ali nije uticalo na nivoe BMP 2. Značajan porast BMP 2 je utvrđen sedmog dana posle prekrivanja pulpe, ali samo kod dijabetičnih pacova (16,7 ± 1 pg/mg, p = 0,001). Kod ovih životinja u istom periodu posle prekrivanja nađena je pozitivna korelacija između nivoa VEGF i BMP 2 (r = 0,905, p = 0,003). Zaključak Dijabetesom indukovan porast ekspresije VEGF ukazuje na promene u inflamatornoj fazi pulpne reparacije. Porast ekspresije BMP 2 ukazuje da se stimulativan reparatorni efekat kalcijum-hidroksida javlja sedmog dana posle prekrivanja dijabetične pulpe. | sr |
dc.language.iso | en | sr |
dc.publisher | Beograd: Srpsko lekarsko društvo | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175021/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Srpski arhiv za celokupno lekarstvo | sr |
dc.subject | dental pulp capping | sr |
dc.subject | diabetes | sr |
dc.subject | vascular endothelial growth factor | sr |
dc.subject | bone morphogenetic protein 2 | sr |
dc.subject | calcium hydroxide | sr |
dc.subject | prekrivanje pulpe | sr |
dc.subject | dijabetes | sr |
dc.subject | vaskularni endotelni faktor rasta | sr |
dc.subject | kostni morfogenetski protein 2 | sr |
dc.subject | kalcijum-hidroksid | sr |
dc.title | The diabetic dental pulp repair: involvement of vascular endothelial growth factor and bone morphogenetic protein 2 | sr |
dc.title | Reparacija dijabetične zubne pulpe – uloga vaskularnog endotelnog faktora rasta i kostnog morfogenetskog proteina 2 | sr |
dc.type | article | sr |
dc.rights.license | BY-NC | sr |
dcterms.abstract | Радовић, Катарина; Васић, Југослав; Рогановић, Јелена; Брковић, Божидар; Илић, Југослав; Репарација дијабетичне зубне пулпе – улога васкуларног ендотелног фактора раста и костног морфогенетског протеина 2; Репарација дијабетичне зубне пулпе – улога васкуларног ендотелног фактора раста и костног морфогенетског протеина 2; | |
dc.citation.volume | 148 | |
dc.citation.issue | 11-12 | |
dc.citation.spage | 673 | |
dc.citation.epage | 678 | |
dc.citation.rank | M23~ | |
dc.identifier.wos | 000604439300002 | |
dc.identifier.doi | 10.2298/SARH200228057I | |
dc.identifier.scopus | 2-s2.0-85099955941 | |
dc.identifier.fulltext | https://smile.stomf.bg.ac.rs/bitstream/id/6157/arhiv.pdf | |
dc.type.version | publishedVersion | sr |