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Association between miR-21/146a/155 level changes and acute genitourinary radiotoxicity in prostate cancer patients: A pilot study
dc.creator | Kopčalić, Katarina | |
dc.creator | Petrović, Nina | |
dc.creator | Stanojković, Tatjana P. | |
dc.creator | Stanković, Vesna | |
dc.creator | Bukumirić, Zoran | |
dc.creator | Roganović, Jelena | |
dc.creator | Mališić, Emina | |
dc.creator | Nikitović, Marina | |
dc.date.accessioned | 2021-04-27T15:02:45Z | |
dc.date.available | 2021-04-27T15:02:45Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0344-0338 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/2594 | |
dc.description.abstract | Introduction: Nearly sixty percent of patients with prostate cancer (PCa) undergo radiation therapy (RT). During the course of treatment patients may experience normal tissue reactions. It is a well established fact that genetic and epigenetic mechanisms, such as microRNA (miRNA) level changes might be associated with radiotoxicity, as a response to irradiation. Materials and methods: This is the first study that has investigated levels of radiosensory miRNAs in association with acute genitourinary radiotoxicity extracted from peripheral blood mononuclear cells (PBCs), in three points; before RT (BRT), after RT (ART) and on the first control examination (FCONT). We measured levels of miR-21/146a/155 expression by quantitative real-time PCR (qRT-PCR), comparative ΔΔCt method, in fifteen patients with localized prostate cancer, treated with three-dimensional conformal radiotherapy (3DCRT). Nine subjects have experienced acute genitourinary (GU) radiotoxicity whereas six where without GU radiotoxicity. Results: Firstly, we detected the highest levels of miR-21 in ART group (p = 0.043) in the patients with acute GU radiotoxicity. Secondly, we found trend towards higher miR-21 levels and significantly higher levels of miR-146a/155 within the patients with acute GU toxicity than in patients without (p = 0.068, p = 0.016, and p = 0.010, respectively). Thirdly, we detected significant change in miR-146a/155 levels within the patients without acute GU radiotoxicity during RT p = 0.042, and p = 0.041, respectively). Conclusion: miR-21/146a/155 might be useful potential factors of radiosensitivity and acute genitourinary radiotoxicity in prostate cancer patients. miRNA might have great potential as predictors of various pathological conditions extracted from PBMCs. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier GmbH | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175021/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Pathology - Research and Practice | sr |
dc.subject | Prostate cancer | sr |
dc.subject | Conformal radiotherapy | sr |
dc.subject | Acute genitourinary radiotoxicity | sr |
dc.subject | miR-21 | sr |
dc.subject | miR-146a | sr |
dc.subject | miR-155 | sr |
dc.title | Association between miR-21/146a/155 level changes and acute genitourinary radiotoxicity in prostate cancer patients: A pilot study | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Станковић, Весна; Малишић, Емина; Никитовић, Марина; Рогановић, Јелена; Копчалић, Катарина; Букумирић, Зоран; Петровић, Нина; Станојковић, Татјана П.; | |
dc.rights.holder | © 2018 Elsevier GmbH | sr |
dc.citation.volume | 215 | |
dc.citation.issue | 4 | |
dc.citation.spage | 626 | |
dc.citation.epage | 631 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000474319300002 | |
dc.identifier.doi | 10.1016/j.prp.2018.12.007 | |
dc.identifier.pmid | 30554863 | |
dc.identifier.scopus | 2-s2.0-85058219558 | |
dc.type.version | publishedVersion | sr |