Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy
Нема приказа
Аутори
Dragović, GordanaToljić, Boško
Jevtović, Đorđe
Lukić, Relja
de Luka, Silvio R.
Trbovich, Alexander
Milašin, Jelena
Чланак у часопису (Објављена верзија)
,
© 2021 Elsevier Inc.
Метаподаци
Приказ свих података о документуАпстракт
Background: Components of the metabolic syndrome (MetS) play an important role in the accelerated aging process. Relative telomere length (RTL) is a marker of biological aging. The aim of our study was to determine RTL and its possible association with MetS and the components of MetS in HIV-infected patients treated with cART.
Methods: We included 24 HIV-infected men, all Caucasians, with successful cART (<50 HIV-RNA copies/mL) and on stable cART for at least 24 months. The presence of MetS and its components was determined by the criteria prescribed by the International Diabetes Federation. RTL was determined by Real-Time PCR and ΔΔCt method. We performed a multiple linear regression modeling on log-transformed RTL (dependant variable) to evaluate which components of the metabolic syndrome as well as cART duration and cART type, had an impact on RTL.
Results: Eleven (45.8%) patients had and 13 (54.2%) had not MetS. All patients, had an undetectable viral RNA and a relatively goo...d immune status. The mean RTL was 0.62 ± 0.15 and 0.95 ± 0.36 in patients with and without MetS, respectively (p = 0.01). Multiple linear regression model showed no significant association between duration of cART, cART type and RTL (p = 0.2165, p = 0.8628, respectively). The same analysis showed that an increase in number of MetS components was associated with shorter telomere length (β = -0.4982, p = 0.042).
Conclusions: We showed for the first time association between RTL shortening in HIV-infected men with metabolic syndrome. Furthermore, our study also indicated that an increment of metabolic syndrome components is strongly associated with shorter telomere length.
Кључне речи:
Relative telomere length / Metabolic syndrome / HIV-infected men on cARTИзвор:
Experimental Gerontology, 2021, 147, May, 111269-Издавач:
- Elsevier Inc.
Финансирање / пројекти:
- "info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175024/RS//" (RS-MESTD-Basic Research (BR or ON)-175024)
Напомена:
- The work was part of the project (Grant No 175024) supported by Ministry of Science and Technological Development of Serbia.
DOI: 10.1016/j.exger.2021.111269
ISSN: 0531-5565
PubMed: 33529748
WoS: 000633367100007
Scopus: 2-s2.0-85100237639
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Dragović, Gordana AU - Toljić, Boško AU - Jevtović, Đorđe AU - Lukić, Relja AU - de Luka, Silvio R. AU - Trbovich, Alexander AU - Milašin, Jelena PY - 2021 UR - https://smile.stomf.bg.ac.rs/handle/123456789/3285 AB - Background: Components of the metabolic syndrome (MetS) play an important role in the accelerated aging process. Relative telomere length (RTL) is a marker of biological aging. The aim of our study was to determine RTL and its possible association with MetS and the components of MetS in HIV-infected patients treated with cART. Methods: We included 24 HIV-infected men, all Caucasians, with successful cART (<50 HIV-RNA copies/mL) and on stable cART for at least 24 months. The presence of MetS and its components was determined by the criteria prescribed by the International Diabetes Federation. RTL was determined by Real-Time PCR and ΔΔCt method. We performed a multiple linear regression modeling on log-transformed RTL (dependant variable) to evaluate which components of the metabolic syndrome as well as cART duration and cART type, had an impact on RTL. Results: Eleven (45.8%) patients had and 13 (54.2%) had not MetS. All patients, had an undetectable viral RNA and a relatively good immune status. The mean RTL was 0.62 ± 0.15 and 0.95 ± 0.36 in patients with and without MetS, respectively (p = 0.01). Multiple linear regression model showed no significant association between duration of cART, cART type and RTL (p = 0.2165, p = 0.8628, respectively). The same analysis showed that an increase in number of MetS components was associated with shorter telomere length (β = -0.4982, p = 0.042). Conclusions: We showed for the first time association between RTL shortening in HIV-infected men with metabolic syndrome. Furthermore, our study also indicated that an increment of metabolic syndrome components is strongly associated with shorter telomere length. PB - Elsevier Inc. T2 - Experimental Gerontology T1 - Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy VL - 147 IS - May SP - 111269 DO - 10.1016/j.exger.2021.111269 ER -
@article{ author = "Dragović, Gordana and Toljić, Boško and Jevtović, Đorđe and Lukić, Relja and de Luka, Silvio R. and Trbovich, Alexander and Milašin, Jelena", year = "2021", abstract = "Background: Components of the metabolic syndrome (MetS) play an important role in the accelerated aging process. Relative telomere length (RTL) is a marker of biological aging. The aim of our study was to determine RTL and its possible association with MetS and the components of MetS in HIV-infected patients treated with cART. Methods: We included 24 HIV-infected men, all Caucasians, with successful cART (<50 HIV-RNA copies/mL) and on stable cART for at least 24 months. The presence of MetS and its components was determined by the criteria prescribed by the International Diabetes Federation. RTL was determined by Real-Time PCR and ΔΔCt method. We performed a multiple linear regression modeling on log-transformed RTL (dependant variable) to evaluate which components of the metabolic syndrome as well as cART duration and cART type, had an impact on RTL. Results: Eleven (45.8%) patients had and 13 (54.2%) had not MetS. All patients, had an undetectable viral RNA and a relatively good immune status. The mean RTL was 0.62 ± 0.15 and 0.95 ± 0.36 in patients with and without MetS, respectively (p = 0.01). Multiple linear regression model showed no significant association between duration of cART, cART type and RTL (p = 0.2165, p = 0.8628, respectively). The same analysis showed that an increase in number of MetS components was associated with shorter telomere length (β = -0.4982, p = 0.042). Conclusions: We showed for the first time association between RTL shortening in HIV-infected men with metabolic syndrome. Furthermore, our study also indicated that an increment of metabolic syndrome components is strongly associated with shorter telomere length.", publisher = "Elsevier Inc.", journal = "Experimental Gerontology", title = "Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy", volume = "147", number = "May", pages = "111269", doi = "10.1016/j.exger.2021.111269" }
Dragović, G., Toljić, B., Jevtović, Đ., Lukić, R., de Luka, S. R., Trbovich, A.,& Milašin, J.. (2021). Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy. in Experimental Gerontology Elsevier Inc.., 147(May), 111269. https://doi.org/10.1016/j.exger.2021.111269
Dragović G, Toljić B, Jevtović Đ, Lukić R, de Luka SR, Trbovich A, Milašin J. Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy. in Experimental Gerontology. 2021;147(May):111269. doi:10.1016/j.exger.2021.111269 .
Dragović, Gordana, Toljić, Boško, Jevtović, Đorđe, Lukić, Relja, de Luka, Silvio R., Trbovich, Alexander, Milašin, Jelena, "Correlation between metabolic syndrome and relative telomere length shortening in HIV/AIDS patients on combined antiretroviral therapy" in Experimental Gerontology, 147, no. May (2021):111269, https://doi.org/10.1016/j.exger.2021.111269 . .