Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp-a laser Doppler flowmetry study
Аутори
Antić, SvetlanaMarković-Vasiljković, Biljana
Dželetović, Bojan
Jelovac, Drago
Kuzmanović-Pfićer, Jovana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objective: This study aims to determine and compare the dental pulp and gingival blood flow in patients referred for oropharyngeal radiotherapy (RT) at three different time points: before the start, immediately after, and six months following the completion of RT. The aim is also to evaluate the dependence of the pulp and gingival blood flow on the radiation dose. Methodology: A prospective study included 10 patients referred for intensity-modulated RT (IMRT) in the oropharyngeal region, with at least one intact tooth surrounded by a healthy gingiva. The dose received by each selected tooth and adjacent gingiva was determined according to the map of treatment planning and computer systems. The blood flow measurements were performed using the laser Doppler flowmetry (LDF) method. Results: Comparing vascular flows at three different time points, the median blood flow in the dental pulp showed no statistically significant difference (p=0.325), contrary to gingiva (p=0.011). Immediately af...ter RT completion, the gingival flow significantly increased compared to its starting point (p=0.012). The pulp flow correlated negatively with the radiation dose, whereas a strong correlation was noted 6 months following the RT completion. Conclusions: RT caused a significant acute gingival blood flow increase, followed by a long-term (over six months) tendency to return to the starting levels. The dental pulp blood flow is differently affected by higher radiation doses (over 50Gy) in comparison to lower doses (below 50Gy). During RT planning, considering the possibility of protecting the teeth localized near the Gross Tumor Volume as a sensitive organ is recommended.
Кључне речи:
Blood flow / Dental pulp / Gingiva / Radiotherapy / Laser Doppler flowmetryИзвор:
Journal of Applied Oral Science, 2022, 30, e20220329-Издавач:
- Faculdade de Odontologia de Bauru da Universidade de Sao Paulo
DOI: 10.1590/1678-7757-2022-0329
ISSN: 1678-7757
PubMed: 36477557
WoS: 000892472700001
Scopus: 2-s2.0-85143420729
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Antić, Svetlana AU - Marković-Vasiljković, Biljana AU - Dželetović, Bojan AU - Jelovac, Drago AU - Kuzmanović-Pfićer, Jovana PY - 2022 UR - https://smile.stomf.bg.ac.rs/handle/123456789/3290 AB - Objective: This study aims to determine and compare the dental pulp and gingival blood flow in patients referred for oropharyngeal radiotherapy (RT) at three different time points: before the start, immediately after, and six months following the completion of RT. The aim is also to evaluate the dependence of the pulp and gingival blood flow on the radiation dose. Methodology: A prospective study included 10 patients referred for intensity-modulated RT (IMRT) in the oropharyngeal region, with at least one intact tooth surrounded by a healthy gingiva. The dose received by each selected tooth and adjacent gingiva was determined according to the map of treatment planning and computer systems. The blood flow measurements were performed using the laser Doppler flowmetry (LDF) method. Results: Comparing vascular flows at three different time points, the median blood flow in the dental pulp showed no statistically significant difference (p=0.325), contrary to gingiva (p=0.011). Immediately after RT completion, the gingival flow significantly increased compared to its starting point (p=0.012). The pulp flow correlated negatively with the radiation dose, whereas a strong correlation was noted 6 months following the RT completion. Conclusions: RT caused a significant acute gingival blood flow increase, followed by a long-term (over six months) tendency to return to the starting levels. The dental pulp blood flow is differently affected by higher radiation doses (over 50Gy) in comparison to lower doses (below 50Gy). During RT planning, considering the possibility of protecting the teeth localized near the Gross Tumor Volume as a sensitive organ is recommended. PB - Faculdade de Odontologia de Bauru da Universidade de Sao Paulo T2 - Journal of Applied Oral Science T1 - Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp-a laser Doppler flowmetry study VL - 30 SP - e20220329 DO - 10.1590/1678-7757-2022-0329 ER -
@article{ author = "Antić, Svetlana and Marković-Vasiljković, Biljana and Dželetović, Bojan and Jelovac, Drago and Kuzmanović-Pfićer, Jovana", year = "2022", abstract = "Objective: This study aims to determine and compare the dental pulp and gingival blood flow in patients referred for oropharyngeal radiotherapy (RT) at three different time points: before the start, immediately after, and six months following the completion of RT. The aim is also to evaluate the dependence of the pulp and gingival blood flow on the radiation dose. Methodology: A prospective study included 10 patients referred for intensity-modulated RT (IMRT) in the oropharyngeal region, with at least one intact tooth surrounded by a healthy gingiva. The dose received by each selected tooth and adjacent gingiva was determined according to the map of treatment planning and computer systems. The blood flow measurements were performed using the laser Doppler flowmetry (LDF) method. Results: Comparing vascular flows at three different time points, the median blood flow in the dental pulp showed no statistically significant difference (p=0.325), contrary to gingiva (p=0.011). Immediately after RT completion, the gingival flow significantly increased compared to its starting point (p=0.012). The pulp flow correlated negatively with the radiation dose, whereas a strong correlation was noted 6 months following the RT completion. Conclusions: RT caused a significant acute gingival blood flow increase, followed by a long-term (over six months) tendency to return to the starting levels. The dental pulp blood flow is differently affected by higher radiation doses (over 50Gy) in comparison to lower doses (below 50Gy). During RT planning, considering the possibility of protecting the teeth localized near the Gross Tumor Volume as a sensitive organ is recommended.", publisher = "Faculdade de Odontologia de Bauru da Universidade de Sao Paulo", journal = "Journal of Applied Oral Science", title = "Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp-a laser Doppler flowmetry study", volume = "30", pages = "e20220329", doi = "10.1590/1678-7757-2022-0329" }
Antić, S., Marković-Vasiljković, B., Dželetović, B., Jelovac, D.,& Kuzmanović-Pfićer, J.. (2022). Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp-a laser Doppler flowmetry study. in Journal of Applied Oral Science Faculdade de Odontologia de Bauru da Universidade de Sao Paulo., 30, e20220329. https://doi.org/10.1590/1678-7757-2022-0329
Antić S, Marković-Vasiljković B, Dželetović B, Jelovac D, Kuzmanović-Pfićer J. Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp-a laser Doppler flowmetry study. in Journal of Applied Oral Science. 2022;30:e20220329. doi:10.1590/1678-7757-2022-0329 .
Antić, Svetlana, Marković-Vasiljković, Biljana, Dželetović, Bojan, Jelovac, Drago, Kuzmanović-Pfićer, Jovana, "Assesment of radiotherapy effects on the blood flow in gingiva and dental pulp-a laser Doppler flowmetry study" in Journal of Applied Oral Science, 30 (2022):e20220329, https://doi.org/10.1590/1678-7757-2022-0329 . .