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dc.creatorAntić, Svetlana
dc.creatorMarković-Vasiljković, Biljana
dc.creatorDželetović, Bojan
dc.creatorJelovac, Drago
dc.creatorKuzmanović-Pfićer, Jovana
dc.date.accessioned2024-01-25T12:31:13Z
dc.date.available2024-01-25T12:31:13Z
dc.date.issued2022
dc.identifier.issn1678-7757
dc.identifier.urihttps://smile.stomf.bg.ac.rs/handle/123456789/3290
dc.description.abstractObjective: This study aims to determine and compare the dental pulp and gingival blood flow in patients referred for oropharyngeal radiotherapy (RT) at three different time points: before the start, immediately after, and six months following the completion of RT. The aim is also to evaluate the dependence of the pulp and gingival blood flow on the radiation dose. Methodology: A prospective study included 10 patients referred for intensity-modulated RT (IMRT) in the oropharyngeal region, with at least one intact tooth surrounded by a healthy gingiva. The dose received by each selected tooth and adjacent gingiva was determined according to the map of treatment planning and computer systems. The blood flow measurements were performed using the laser Doppler flowmetry (LDF) method. Results: Comparing vascular flows at three different time points, the median blood flow in the dental pulp showed no statistically significant difference (p=0.325), contrary to gingiva (p=0.011). Immediately after RT completion, the gingival flow significantly increased compared to its starting point (p=0.012). The pulp flow correlated negatively with the radiation dose, whereas a strong correlation was noted 6 months following the RT completion. Conclusions: RT caused a significant acute gingival blood flow increase, followed by a long-term (over six months) tendency to return to the starting levels. The dental pulp blood flow is differently affected by higher radiation doses (over 50Gy) in comparison to lower doses (below 50Gy). During RT planning, considering the possibility of protecting the teeth localized near the Gross Tumor Volume as a sensitive organ is recommended.sr
dc.language.isoensr
dc.publisherFaculdade de Odontologia de Bauru da Universidade de Sao Paulosr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceJournal of Applied Oral Sciencesr
dc.subjectBlood flowsr
dc.subjectDental pulpsr
dc.subjectGingivasr
dc.subjectRadiotherapysr
dc.subjectLaser Doppler flowmetrysr
dc.titleAssesment of radiotherapy effects on the blood flow in gingiva and dental pulp-a laser Doppler flowmetry studysr
dc.typearticlesr
dc.rights.licenseBYsr
dc.citation.volume30
dc.citation.spagee20220329
dc.identifier.wos000892472700001
dc.identifier.doi10.1590/1678-7757-2022-0329
dc.identifier.pmid36477557
dc.identifier.scopus2-s2.0-85143420729
dc.identifier.fulltexthttp://smile.stomf.bg.ac.rs/bitstream/id/8729/bitstream_8729.pdf
dc.type.versionpublishedVersionsr


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