Immunoreactivity to food protein in pathogenesis of recurrent oral ulceration

Abstract

Based on a complete analysis of the results , we came to the following conclusions: 1. Characteristics of ROU: • The experimental group consisted of 38% men and 62% women. • The average age of the experimental group was 40.32 years. • The most common localization (53%) of ROU is the buccal and labial mucosa , then the tong (14%) and the whole mouth in 13% of patients. • In 86% of cases, the characteristics of ROU corresponded to clinical picture of aphthae minor, while in 14% of cases corresponded to aphthae major. • Over half of the patients (58%) at the time of the physical examination had 1-5 ulcerations in the oral cavity, 32% had from 5-10, while 10% had more than 10 ulcerations in the oral cavity. • In 52% of patients, ROU first emerged several years ago, in 40% of them for more than a year, while in 6% change first occurred in the period of 1-6 months ago, only one respondent (2%) stated that the ulcers first appeared over a period of 6-12 months before. • ROU relapse appeared from one month in 40% of patients, 30% of them stated incidence of recurrence of 2-5 times in 6 months, while in 18% of patients these changes occurred several times per month, the lowest number of patients (12%) stated that the recurrence comes from 1-3 times per year. • In the 86% of patients ROU heal over a period of 7-14 days , while in 14% of cases, heal more than one month . 2. Sensitization to food proteins: • In 14 % of patients with ROU elevated humoral immunoreactivity to gliadin is registered. • Elevated humoral immunoreactivity to the total cow milk protein was detected in more than half (72 %) patients with ROU. • Serum antibodies in the elevated concentration was present against: -α - casein in 72%, -β- casein in 62%, -κ- casein in 52%, -α - lactalbumin in 18%, - lactoferrin in 20%, -β - lactoglobulin A and 24% in -β - lactoglobulin B in 30% of patients. 3. Based on these results we conclude that cow's milk protein may be one of the etiological factors in the development of ROU .

Na osnovu kompletne analize dobijenih rezultata, došli smo do sledećih zaključaka: 1. Karakteristike ROU: • Eksperimentalnu grupu je činilo 38% muškaraca i 62% žena. • Prosečna starost eksperimentalne grupe je iznosila 40.32 godine. • Najzastupljenija lokalizacija (53%) ROU su bukalna i labijalna sluzokoža, zatim jezik sa 14% i cela usta u 13% pacijenata. • U 86% slučajeva karakteristike ROU su odgovarale kliničkoj slici afta minor, dok su u 14% slučajeva odgovarale aftama major. • Više od polovine pacijenata (58%) je u momentu kliničkog pregleda imalo od 1-5 ulceracija u usnoj duplji, 32% je imalo od 5-10 promena, dok je 10% imalo više od 10 ulceracija u ustima. • Kod 52% pacijenata, ROU su se prvi put pojavile pre više godina, kod 40% njih pre više od godinu dana, dok su se u 6% slučajeva promene prvi put javile u periodu od pre 1-6 meseci; samo jedan ispitanik (2%) je izjavio da su se ulceracije prvi put pojavile u periodu od pre 6-12 meseci. • Recidiv ROU se javljao jednom mesečno u 40% pacijenata, 30% njih je navelo da je učestalost recidiva od 2-5 puta u toku 6 meseci, dok su se u 18% njih promene javljale više puta mesečno; najmanji broj pacijenata (12%) je izjavio da do recidiva dolazi od 1-3 puta u toku jedne godine. • U 86% pacijenata ROU zarastaju u periodu od 7-14 dana, dok u 14% slučajeva zarastaju duže od mesec dana. 2. Preosetljivost na proteine hrane: • Kod 14% ispitanih pacijenata sa ROU registrovana je povišena humoralna imunoreaktivnost na gliadin. • Povišena humoralna imunoreaktivnost na ukupne proteine kravljeg mleka je detektovana kod više od polovine (72%) pacijenata sa ROU. • Serumska antitela su u povišenoj koncentraciji bila prisutna na: - α-kazein u 72%, - β-kazein u 62%, - κ-kazein u 52%, - α-laktalbumin u 18%, - laktoferin u 20%, - β-laktoglobulin A u 24% i - β-laktoglobulin B u 30%. 3. Na osnovu dobijenih rezultata konstatujemo da proteini kravljeg mleka mogu biti jedan od etioloških faktora u nastanku ROU.