Mast cells in periapical lesions: potential role in their pathogenesis
Само за регистроване кориснике
2010
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Objective: The aim of this study was to qualitatively and semi-quantitatively analyze mast cells in periapical lesions. Materials and methods: Biopsy specimens of 96 periapical lesions were stained with hematoxylin-eosin, histochemical Giemsa and immunohistochemical CD 117 (C kit) antibody. Mast cell count below 100 mast cells on 1000 fields of high power magnification was noted as 'negative', 101-400 as 'mild', 401-800 cells as 'moderate', and over 800 cells as 'severe'. Results: Mast cells are found in 68 (70.8%) lesions. The presence of mast cells was greater in cysts than in granulomas (P lt 0.0028). There was no difference in semi-quantitative expression of CD 117 in granulomas and cysts (P > 0.05). Mast cells were placed in both: inflammatory infiltrate and in fibroblastic areas of periapical lesions, and their presence was most frequently mild to moderate. Conclusions: The findings of present study could suggest a role of mast cells in regulation of cellular immune mechanisms ...in periapical lesions, balancing between alterative and reparatory processes in inflamed periapical tissue.
Кључне речи:
CD 117 / mast cells / periapical lesionsИзвор:
Journal of Oral Pathology & Medicine, 2010, 39, 3, 257-262Издавач:
- Wiley-Blackwell Publishing, Inc, Malden
DOI: 10.1111/j.1600-0714.2009.00870.x
ISSN: 0904-2512
PubMed: 20359310
WoS: 000274668700010
Scopus: 2-s2.0-77249172276
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Dražić, Radojica AU - Sopta, Jelena AU - Minić, Arsa J. PY - 2010 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1521 AB - Objective: The aim of this study was to qualitatively and semi-quantitatively analyze mast cells in periapical lesions. Materials and methods: Biopsy specimens of 96 periapical lesions were stained with hematoxylin-eosin, histochemical Giemsa and immunohistochemical CD 117 (C kit) antibody. Mast cell count below 100 mast cells on 1000 fields of high power magnification was noted as 'negative', 101-400 as 'mild', 401-800 cells as 'moderate', and over 800 cells as 'severe'. Results: Mast cells are found in 68 (70.8%) lesions. The presence of mast cells was greater in cysts than in granulomas (P lt 0.0028). There was no difference in semi-quantitative expression of CD 117 in granulomas and cysts (P > 0.05). Mast cells were placed in both: inflammatory infiltrate and in fibroblastic areas of periapical lesions, and their presence was most frequently mild to moderate. Conclusions: The findings of present study could suggest a role of mast cells in regulation of cellular immune mechanisms in periapical lesions, balancing between alterative and reparatory processes in inflamed periapical tissue. PB - Wiley-Blackwell Publishing, Inc, Malden T2 - Journal of Oral Pathology & Medicine T1 - Mast cells in periapical lesions: potential role in their pathogenesis VL - 39 IS - 3 SP - 257 EP - 262 DO - 10.1111/j.1600-0714.2009.00870.x ER -
@article{ author = "Dražić, Radojica and Sopta, Jelena and Minić, Arsa J.", year = "2010", abstract = "Objective: The aim of this study was to qualitatively and semi-quantitatively analyze mast cells in periapical lesions. Materials and methods: Biopsy specimens of 96 periapical lesions were stained with hematoxylin-eosin, histochemical Giemsa and immunohistochemical CD 117 (C kit) antibody. Mast cell count below 100 mast cells on 1000 fields of high power magnification was noted as 'negative', 101-400 as 'mild', 401-800 cells as 'moderate', and over 800 cells as 'severe'. Results: Mast cells are found in 68 (70.8%) lesions. The presence of mast cells was greater in cysts than in granulomas (P lt 0.0028). There was no difference in semi-quantitative expression of CD 117 in granulomas and cysts (P > 0.05). Mast cells were placed in both: inflammatory infiltrate and in fibroblastic areas of periapical lesions, and their presence was most frequently mild to moderate. Conclusions: The findings of present study could suggest a role of mast cells in regulation of cellular immune mechanisms in periapical lesions, balancing between alterative and reparatory processes in inflamed periapical tissue.", publisher = "Wiley-Blackwell Publishing, Inc, Malden", journal = "Journal of Oral Pathology & Medicine", title = "Mast cells in periapical lesions: potential role in their pathogenesis", volume = "39", number = "3", pages = "257-262", doi = "10.1111/j.1600-0714.2009.00870.x" }
Dražić, R., Sopta, J.,& Minić, A. J.. (2010). Mast cells in periapical lesions: potential role in their pathogenesis. in Journal of Oral Pathology & Medicine Wiley-Blackwell Publishing, Inc, Malden., 39(3), 257-262. https://doi.org/10.1111/j.1600-0714.2009.00870.x
Dražić R, Sopta J, Minić AJ. Mast cells in periapical lesions: potential role in their pathogenesis. in Journal of Oral Pathology & Medicine. 2010;39(3):257-262. doi:10.1111/j.1600-0714.2009.00870.x .
Dražić, Radojica, Sopta, Jelena, Minić, Arsa J., "Mast cells in periapical lesions: potential role in their pathogenesis" in Journal of Oral Pathology & Medicine, 39, no. 3 (2010):257-262, https://doi.org/10.1111/j.1600-0714.2009.00870.x . .