Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition
Само за регистроване кориснике
2010
Аутори
Petković, A. B.Matić, S. M.
Stamatović, Novak
Vojvodić, Danilo
Todorović, T. M.
Lazić, Z. R.
Kozomara, Ružica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Analysis of pen-implant crevicular fluid (PICF) offers a non-invasive means of studying the host response in pen-implant disease and may provide an early indication of patients at risk for active disease. This study examined the PICF levels of interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in patients with non-manifesting inflammation, early and late stages of mucositis. The study group comprised 90 adult healthy volunteers with endosseal titanium implants inserted. Samples were taken from pen-implant sulcus using a filter paper technique. Implant tissues were categorized clinically as healthy, early mucositis or advanced mucositis. Clinical manifestations were determined by: gingival index and bleeding on probing, plaque index and radiographic analyses. Cytokine concentrations were assesed using commercially available enzyme-linked immunosorbent assay kits. Patients from the contr...ol group (healthy patients) have significantly lower concentrations of IL-1 beta, TNF-alpha, IL-8 and MIP-1 alpha in PICF compared with both groups with mucositis. Positive correlation was noted in the control group between IL-1 beta and TNF-alpha and between MIP-1 alpha and IL-8 in the group with early mucositis. The results suggest that cytokines could be prognostic markers of implant failure.
Кључне речи:
cytokine / dental implants / peri-implantitisИзвор:
International Journal of Oral & Maxillofacial Surgery, 2010, 39, 5, 478-485Издавач:
- Churchill Livingstone, Edinburgh
DOI: 10.1016/j.ijom.2010.01.014
ISSN: 0901-5027
PubMed: 20207110
WoS: 000278584400011
Scopus: 2-s2.0-77952238280
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Petković, A. B. AU - Matić, S. M. AU - Stamatović, Novak AU - Vojvodić, Danilo AU - Todorović, T. M. AU - Lazić, Z. R. AU - Kozomara, Ružica PY - 2010 UR - https://smile.stomf.bg.ac.rs/handle/123456789/1594 AB - Analysis of pen-implant crevicular fluid (PICF) offers a non-invasive means of studying the host response in pen-implant disease and may provide an early indication of patients at risk for active disease. This study examined the PICF levels of interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in patients with non-manifesting inflammation, early and late stages of mucositis. The study group comprised 90 adult healthy volunteers with endosseal titanium implants inserted. Samples were taken from pen-implant sulcus using a filter paper technique. Implant tissues were categorized clinically as healthy, early mucositis or advanced mucositis. Clinical manifestations were determined by: gingival index and bleeding on probing, plaque index and radiographic analyses. Cytokine concentrations were assesed using commercially available enzyme-linked immunosorbent assay kits. Patients from the control group (healthy patients) have significantly lower concentrations of IL-1 beta, TNF-alpha, IL-8 and MIP-1 alpha in PICF compared with both groups with mucositis. Positive correlation was noted in the control group between IL-1 beta and TNF-alpha and between MIP-1 alpha and IL-8 in the group with early mucositis. The results suggest that cytokines could be prognostic markers of implant failure. PB - Churchill Livingstone, Edinburgh T2 - International Journal of Oral & Maxillofacial Surgery T1 - Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition VL - 39 IS - 5 SP - 478 EP - 485 DO - 10.1016/j.ijom.2010.01.014 ER -
@article{ author = "Petković, A. B. and Matić, S. M. and Stamatović, Novak and Vojvodić, Danilo and Todorović, T. M. and Lazić, Z. R. and Kozomara, Ružica", year = "2010", abstract = "Analysis of pen-implant crevicular fluid (PICF) offers a non-invasive means of studying the host response in pen-implant disease and may provide an early indication of patients at risk for active disease. This study examined the PICF levels of interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in patients with non-manifesting inflammation, early and late stages of mucositis. The study group comprised 90 adult healthy volunteers with endosseal titanium implants inserted. Samples were taken from pen-implant sulcus using a filter paper technique. Implant tissues were categorized clinically as healthy, early mucositis or advanced mucositis. Clinical manifestations were determined by: gingival index and bleeding on probing, plaque index and radiographic analyses. Cytokine concentrations were assesed using commercially available enzyme-linked immunosorbent assay kits. Patients from the control group (healthy patients) have significantly lower concentrations of IL-1 beta, TNF-alpha, IL-8 and MIP-1 alpha in PICF compared with both groups with mucositis. Positive correlation was noted in the control group between IL-1 beta and TNF-alpha and between MIP-1 alpha and IL-8 in the group with early mucositis. The results suggest that cytokines could be prognostic markers of implant failure.", publisher = "Churchill Livingstone, Edinburgh", journal = "International Journal of Oral & Maxillofacial Surgery", title = "Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition", volume = "39", number = "5", pages = "478-485", doi = "10.1016/j.ijom.2010.01.014" }
Petković, A. B., Matić, S. M., Stamatović, N., Vojvodić, D., Todorović, T. M., Lazić, Z. R.,& Kozomara, R.. (2010). Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition. in International Journal of Oral & Maxillofacial Surgery Churchill Livingstone, Edinburgh., 39(5), 478-485. https://doi.org/10.1016/j.ijom.2010.01.014
Petković AB, Matić SM, Stamatović N, Vojvodić D, Todorović TM, Lazić ZR, Kozomara R. Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition. in International Journal of Oral & Maxillofacial Surgery. 2010;39(5):478-485. doi:10.1016/j.ijom.2010.01.014 .
Petković, A. B., Matić, S. M., Stamatović, Novak, Vojvodić, Danilo, Todorović, T. M., Lazić, Z. R., Kozomara, Ružica, "Proinflammatory cytokines (IL-1 beta and TNF-alpha) and chemokines (IL-8 and MIP-1 alpha as markers of pen-implant tissue condition" in International Journal of Oral & Maxillofacial Surgery, 39, no. 5 (2010):478-485, https://doi.org/10.1016/j.ijom.2010.01.014 . .