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Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain
dc.creator | Mladenović, Irena | |
dc.creator | Supić, Gordana | |
dc.creator | Kozomara, Ružica | |
dc.creator | Dodić, Slobodan | |
dc.creator | Ivković, Nedeljka | |
dc.creator | Milićević, Bojana | |
dc.creator | Simić, Ivana | |
dc.creator | Magić, Zvonko | |
dc.date.accessioned | 2020-07-02T13:05:19Z | |
dc.date.available | 2020-07-02T13:05:19Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2333-0384 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/2124 | |
dc.description.abstract | Aims: To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, and postoperative pain. Methods: A total of 90 patients with a diagnosis of painful TMD and 92 matched controls were investigated for the presence of TMD, TMD pain, and psychosocial variables by the Research Diagnostic Criteria for TMD. In a prospective cohort study of 40 subjects who underwent extraction of at least one fully impacted mandibular third molar, subjects had 6 months post-surgery follow-up of postoperative pain. DNA extracted from peripheral blood was genotyped for three COMT polymorphisms (rs4680, rs6269, and rs165774) by real-time TaqMan method. The association between COMT polymorphisms and clinical variables was determined by calculating odds ratios (OR) and their 95% confidence intervals (CO. Results: Homozygous AA genotype and heterozygous variant A allele carriers (genotype AG/AA) for rs165774 polymorphism were associated with increased risk of TMD compared to wild type (wt) GG genotype (OR = 9.448, P =.006; OR = 2.088, P =.017, respectively). In addition, AA genotype was associated with increased risk of arthralgia (OR = 4.448, P =.011), myofascial pain (OR = 3.543, P =.035), and chronic TMD pain (OR = 6.173, P =.006), compared to wt genotype. AA genotype for rs6269 polymorphism was related to less postoperative chronic TMD pain (P =.025) and lower postoperative acute pain at the extraction site (P =.030). No associations with depression and somatization were observed. Conclusion: AA genotype of rs165774 could be a significant risk factor for the development of TMD and TMD pain, while AA genotype of rs6269 presents less postoperative chronic TMD pain and acute pain at a dental extraction site. | en |
dc.publisher | Quintessence Publishing Co Inc, Hanover Park | |
dc.relation | Ministry of Science and TechnologyMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT) [19/6-020/961-175/12] | |
dc.rights | restrictedAccess | |
dc.source | Journal of Oral & Facial Pain & Headache | |
dc.subject | COMT | en |
dc.subject | genetic polymorphisms | en |
dc.subject | pain | en |
dc.subject | temporomandibular disorders | en |
dc.subject | third molar surgery | en |
dc.title | Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Магић, Звонко; Додић, Слободан; Козомара, Ружица; Младеновић, Ирена; Ивковић, Недељка; Милићевић, Бојана; Супић, Гордана; Симић, Ивана; | |
dc.citation.volume | 30 | |
dc.citation.issue | 4 | |
dc.citation.spage | 302 | |
dc.citation.epage | 310 | |
dc.citation.other | 30(4): 302-310 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000387521700004 | |
dc.identifier.doi | 10.11607/ofph.1688 | |
dc.identifier.pmid | 27792797 | |
dc.identifier.scopus | 2-s2.0-85010699650 | |
dc.type.version | publishedVersion |