Study toward resolving the controversy over the definition of allergic fungal rhinosinusitis
2018
Аутори
Barac, AleksandraStevanović, Goran
Pekmezović, Marina
Rakočević, Zoran
Stošović, Rajica
Erović, Boban
Tomić-Spirić, Vesna
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Dysbiosis of the microbiome on the airway mucosa leads to the development of chronic inflammatory and allergic disorders. The aim of this study was to consider the potential diagnostic criteria for allergic fungal rhinosinusitis (AFRS) and nonallergic fungal rhinosinusitis (FRS), and the role of fungal presence in an environment for the development of AFRS. In this study, 136 patients were divided into two groups: patients with positive specific immunoglobulin E (sIgE) and fungal finding (AFRS group), and patients with negative sIgE and positive fungal finding (FRS group). The study design included: anamnesis data, sIgE, eosinophil count and skin-prick test, rhinology and computerized tomography (CT) observation and mycological finding. Our results showed: (i) the prevalence in Serbia is: AFRS 1.3%, FRS 2.8%; (ii) 30.4% patients with sIgE+ had more often severe and recurrent chronic rhinosinusitis (CRS) (P = .005) and the presence of polyps (P = .025); (iii) 46.4% patients with sIgE+ h...ad positive fungi on the sinonasal mucosa and were considered as AFRS; (iv) patients with AFRS had more frequent asthma (P = .024) and chronicity of CRS > 10 years (P = .000). The persistent fungal presence and prolonged duration of CRS could be a silent threat for the progression of inflammation and development of FRS. Lavage with hypertonic-NaCl should be included in the everyday hygiene routine in an effort to decrease fungal load and antigenic exposure. The presence of allergological parameters and better response to corticosteroid therapy in AFRS patients should be considered as crucial diagnostic criteria for AFRS.
Кључне речи:
allergic fungal rhinosinusitis / chronic rhinosinusitis / nasal polyps / fungi / sinonasal mucosaИзвор:
Medical Mycology, 2018, 56, 2, 162-171Издавач:
- Oxford Univ Press, Oxford
Финансирање / пројекти:
- Значај доказивања раних лабораторијских биомаркера за исход инвазивних гљивичних инфекција код нас (RS-MESTD-Basic Research (BR or ON)-175034)
- Клиничко епидемиолошка истраживања поремећаја здравља од јавноздравственог значаја за становништво Србије (RS-MESTD-Basic Research (BR or ON)-175025)
- Функционални, функционализовани и усавршени нано материјали (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45005)
DOI: 10.1093/mmy/myx032
ISSN: 1369-3786
PubMed: 28482010
WoS: 000426074700003
Scopus: 2-s2.0-85042648779
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Barac, Aleksandra AU - Stevanović, Goran AU - Pekmezović, Marina AU - Rakočević, Zoran AU - Stošović, Rajica AU - Erović, Boban AU - Tomić-Spirić, Vesna PY - 2018 UR - https://smile.stomf.bg.ac.rs/handle/123456789/2310 AB - Dysbiosis of the microbiome on the airway mucosa leads to the development of chronic inflammatory and allergic disorders. The aim of this study was to consider the potential diagnostic criteria for allergic fungal rhinosinusitis (AFRS) and nonallergic fungal rhinosinusitis (FRS), and the role of fungal presence in an environment for the development of AFRS. In this study, 136 patients were divided into two groups: patients with positive specific immunoglobulin E (sIgE) and fungal finding (AFRS group), and patients with negative sIgE and positive fungal finding (FRS group). The study design included: anamnesis data, sIgE, eosinophil count and skin-prick test, rhinology and computerized tomography (CT) observation and mycological finding. Our results showed: (i) the prevalence in Serbia is: AFRS 1.3%, FRS 2.8%; (ii) 30.4% patients with sIgE+ had more often severe and recurrent chronic rhinosinusitis (CRS) (P = .005) and the presence of polyps (P = .025); (iii) 46.4% patients with sIgE+ had positive fungi on the sinonasal mucosa and were considered as AFRS; (iv) patients with AFRS had more frequent asthma (P = .024) and chronicity of CRS > 10 years (P = .000). The persistent fungal presence and prolonged duration of CRS could be a silent threat for the progression of inflammation and development of FRS. Lavage with hypertonic-NaCl should be included in the everyday hygiene routine in an effort to decrease fungal load and antigenic exposure. The presence of allergological parameters and better response to corticosteroid therapy in AFRS patients should be considered as crucial diagnostic criteria for AFRS. PB - Oxford Univ Press, Oxford T2 - Medical Mycology T1 - Study toward resolving the controversy over the definition of allergic fungal rhinosinusitis VL - 56 IS - 2 SP - 162 EP - 171 DO - 10.1093/mmy/myx032 ER -
@article{ author = "Barac, Aleksandra and Stevanović, Goran and Pekmezović, Marina and Rakočević, Zoran and Stošović, Rajica and Erović, Boban and Tomić-Spirić, Vesna", year = "2018", abstract = "Dysbiosis of the microbiome on the airway mucosa leads to the development of chronic inflammatory and allergic disorders. The aim of this study was to consider the potential diagnostic criteria for allergic fungal rhinosinusitis (AFRS) and nonallergic fungal rhinosinusitis (FRS), and the role of fungal presence in an environment for the development of AFRS. In this study, 136 patients were divided into two groups: patients with positive specific immunoglobulin E (sIgE) and fungal finding (AFRS group), and patients with negative sIgE and positive fungal finding (FRS group). The study design included: anamnesis data, sIgE, eosinophil count and skin-prick test, rhinology and computerized tomography (CT) observation and mycological finding. Our results showed: (i) the prevalence in Serbia is: AFRS 1.3%, FRS 2.8%; (ii) 30.4% patients with sIgE+ had more often severe and recurrent chronic rhinosinusitis (CRS) (P = .005) and the presence of polyps (P = .025); (iii) 46.4% patients with sIgE+ had positive fungi on the sinonasal mucosa and were considered as AFRS; (iv) patients with AFRS had more frequent asthma (P = .024) and chronicity of CRS > 10 years (P = .000). The persistent fungal presence and prolonged duration of CRS could be a silent threat for the progression of inflammation and development of FRS. Lavage with hypertonic-NaCl should be included in the everyday hygiene routine in an effort to decrease fungal load and antigenic exposure. The presence of allergological parameters and better response to corticosteroid therapy in AFRS patients should be considered as crucial diagnostic criteria for AFRS.", publisher = "Oxford Univ Press, Oxford", journal = "Medical Mycology", title = "Study toward resolving the controversy over the definition of allergic fungal rhinosinusitis", volume = "56", number = "2", pages = "162-171", doi = "10.1093/mmy/myx032" }
Barac, A., Stevanović, G., Pekmezović, M., Rakočević, Z., Stošović, R., Erović, B.,& Tomić-Spirić, V.. (2018). Study toward resolving the controversy over the definition of allergic fungal rhinosinusitis. in Medical Mycology Oxford Univ Press, Oxford., 56(2), 162-171. https://doi.org/10.1093/mmy/myx032
Barac A, Stevanović G, Pekmezović M, Rakočević Z, Stošović R, Erović B, Tomić-Spirić V. Study toward resolving the controversy over the definition of allergic fungal rhinosinusitis. in Medical Mycology. 2018;56(2):162-171. doi:10.1093/mmy/myx032 .
Barac, Aleksandra, Stevanović, Goran, Pekmezović, Marina, Rakočević, Zoran, Stošović, Rajica, Erović, Boban, Tomić-Spirić, Vesna, "Study toward resolving the controversy over the definition of allergic fungal rhinosinusitis" in Medical Mycology, 56, no. 2 (2018):162-171, https://doi.org/10.1093/mmy/myx032 . .