Приказ основних података о документу
The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population
dc.creator | Matić Petrović, Sanja | |
dc.creator | Nikolić, Nadja | |
dc.creator | Toljić, Boško | |
dc.creator | Arambašić-Jovanović, Jelena | |
dc.creator | Miličić, Biljana | |
dc.creator | Miličić, Tanja | |
dc.creator | Jotić, Aleksandra | |
dc.creator | Vidaković, Melita | |
dc.creator | Milašin, Jelena | |
dc.creator | Pucar, Ana | |
dc.date.accessioned | 2021-03-29T23:19:01Z | |
dc.date.available | 2021-03-29T23:19:01Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0003-9969 | |
dc.identifier.uri | https://smile.stomf.bg.ac.rs/handle/123456789/2571 | |
dc.description.abstract | Objectives: Aiming to show that periodontitis (PD) and type 2 diabetes (T2D) are bidirectionally related and potentially linked by inflammatory cytokines, we searched for association between -308 G/A Tumor necrosis factor-alpha (TNFα), +252A/G Lymphotoxin-alpha (LTα), +36A/G Tumor necrosis factor receptor 1 (TNFR1) and +676 T/G tumor necrosis factor receptor 2 (TNFR2) single nucleotide polymorphisms (SNPs) and: risk of PD or PD + T2D; periodontitis parameters in PD and PD + T2D; serum levels of cytokines/their receptors. Relationship between periodontal inflammation and serum cytokine/receptor levels was also assessed. Design: Subjects were stratified as: 57 healthy controls (HC); 58 PD; 65 PD + T2D. Sociodemographic, environmental, behavioral and periodontal clinical data were recorded. SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism, while cytokines/receptors levels were quantified by enzyme-linked immunosorbent assay. Impact of periodontal inflammation was measured using periodontal inflamed surface area (PISA). Results: TNFα AA genotype showed protective effect in T2D + PD compared to PD, even adjusted for behavioral/environmental factors (OR 0.18; 95 %CI 0.037-0.886; p = 0.035). LTα AG heterozygotes had increased risk of PD (OR 3.27; 95 %CI 1.35-7.96; p = 0.016), while TNFR2 TG genotype had protective effect (OR = 0.44; 95 %CI 0.954-0.9794; p = 0.043). TNFR1 AA was predictor of periodontal pocket depth and clinical attachment loss in PD. Correlation between TNFR2 concentration and PISA was negative in PD, positive in PD + T2D. Conclusions: None of the SNPs showed cross-susceptibility between PD and T2D. + 252A/G LTα and +676 T/G TNFR2 SNPs are associated with PD risk. Periodontal destruction in healthy individuals is influenced by TNFR1 genotype. Impact of periodontal on systemic inflammation is masked by T2D. | sr |
dc.language.iso | en | sr |
dc.publisher | Elsevier Inc. | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41008/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175075/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | Archives of Oral Biology | sr |
dc.subject | Periodontitis | sr |
dc.subject | Single nucleotide polymorphisms | sr |
dc.subject | Tumor necrosis factor - alpha | sr |
dc.subject | Tumor necrosis factor receptors | sr |
dc.subject | Type 2 diabetes mellitus | sr |
dc.title | The association of tumor necrosis factor alpha, lymphotoxin alpha, tumor necrosis factor receptor 1 and tumor necrosis factor receptor 2 gene polymorphisms and serum levels with periodontitis and type 2 diabetes in Serbian population | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Николић, Надја; Тољић, Бошко; Aрамбашић-Јовановић, Јелена; Миличић, Биљана; Миличић, Тања; Јотић, Aлександра; Видаковић, Мелита; Пуцар, Aна; Матић Петровић, Сања; Милашин, Јелена; | |
dc.citation.volume | 120 | |
dc.citation.spage | 104929 | |
dc.identifier.wos | 000588270000009 | |
dc.identifier.doi | 10.1016/j.archoralbio.2020.104929 | |
dc.identifier.pmid | 33091664 | |
dc.identifier.scopus | 2-s2.0-85092640281 | |
dc.type.version | publishedVersion | sr |