HIV-Infected Patients as a Model of Aging
Аутори
Toljić, BoškoMilašin, Jelena
de Luka, Silvio R.
Dragović, Gordana
Jevtović, Đorđe
Maslać, Aleksandar
Ristić-Đurović, Jasna
Trbovich, Alexander M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We appraised the relationship between the biological and the chrono-
logical age and estimated the rate of biological aging in HIV-infected patients. Two
independent biomarkers, the relative telomere length and iron metabolism parame-
ters, were analyzed in younger (,35) and older (.50) HIV-infected and uninfected
patients (control group). In our control group, telomeres of younger patients were
significantly longer than telomeres of older ones. However, in HIV-infected partici-
pants, the difference in the length of telomeres was lost. By combining the length of
telomeres with serum iron, ferritin, and transferrin iron-binding capacity, a new for-
mula for determination of the aging process was developed. The life expectancy of
the healthy population was related to their biological age, and HIV-infected patients
were biologically older. The effect of antiretroviral HIV drug therapies varied with
respect to the biological aging process.
IMPORTANCE This article is focused on... the dynamics of human aging. Moreover, its
interdisciplinary approach is applicable to various systems that are aging.
Кључне речи:
HIV / aging / pharmacotherapy / iron / telomereИзвор:
Microbiology Spectrum, 2023, 11, 3, e00532-23-Издавач:
- American Society for Microbiology
Финансирање / пројекти:
- Ministry of Education, Science, and Technological Development, Republic of Serbia [451-03-47/2023-01/200129, ON175075, ON175024, III 41019, III 41013, 45003]
DOI: 10.1128/spectrum.00532-23
ISSN: 2165-0497
PubMed: 37093018
WoS: 001022924100094
Scopus: 2-s2.0-85163913325
Колекције
Институција/група
Stomatološki fakultetTY - JOUR AU - Toljić, Boško AU - Milašin, Jelena AU - de Luka, Silvio R. AU - Dragović, Gordana AU - Jevtović, Đorđe AU - Maslać, Aleksandar AU - Ristić-Đurović, Jasna AU - Trbovich, Alexander M. PY - 2023 UR - https://smile.stomf.bg.ac.rs/handle/123456789/3281 AB - We appraised the relationship between the biological and the chrono- logical age and estimated the rate of biological aging in HIV-infected patients. Two independent biomarkers, the relative telomere length and iron metabolism parame- ters, were analyzed in younger (,35) and older (.50) HIV-infected and uninfected patients (control group). In our control group, telomeres of younger patients were significantly longer than telomeres of older ones. However, in HIV-infected partici- pants, the difference in the length of telomeres was lost. By combining the length of telomeres with serum iron, ferritin, and transferrin iron-binding capacity, a new for- mula for determination of the aging process was developed. The life expectancy of the healthy population was related to their biological age, and HIV-infected patients were biologically older. The effect of antiretroviral HIV drug therapies varied with respect to the biological aging process. IMPORTANCE This article is focused on the dynamics of human aging. Moreover, its interdisciplinary approach is applicable to various systems that are aging. PB - American Society for Microbiology T2 - Microbiology Spectrum T1 - HIV-Infected Patients as a Model of Aging VL - 11 IS - 3 SP - e00532-23 DO - 10.1128/spectrum.00532-23 ER -
@article{ author = "Toljić, Boško and Milašin, Jelena and de Luka, Silvio R. and Dragović, Gordana and Jevtović, Đorđe and Maslać, Aleksandar and Ristić-Đurović, Jasna and Trbovich, Alexander M.", year = "2023", abstract = "We appraised the relationship between the biological and the chrono- logical age and estimated the rate of biological aging in HIV-infected patients. Two independent biomarkers, the relative telomere length and iron metabolism parame- ters, were analyzed in younger (,35) and older (.50) HIV-infected and uninfected patients (control group). In our control group, telomeres of younger patients were significantly longer than telomeres of older ones. However, in HIV-infected partici- pants, the difference in the length of telomeres was lost. By combining the length of telomeres with serum iron, ferritin, and transferrin iron-binding capacity, a new for- mula for determination of the aging process was developed. The life expectancy of the healthy population was related to their biological age, and HIV-infected patients were biologically older. The effect of antiretroviral HIV drug therapies varied with respect to the biological aging process. IMPORTANCE This article is focused on the dynamics of human aging. Moreover, its interdisciplinary approach is applicable to various systems that are aging.", publisher = "American Society for Microbiology", journal = "Microbiology Spectrum", title = "HIV-Infected Patients as a Model of Aging", volume = "11", number = "3", pages = "e00532-23", doi = "10.1128/spectrum.00532-23" }
Toljić, B., Milašin, J., de Luka, S. R., Dragović, G., Jevtović, Đ., Maslać, A., Ristić-Đurović, J.,& Trbovich, A. M.. (2023). HIV-Infected Patients as a Model of Aging. in Microbiology Spectrum American Society for Microbiology., 11(3), e00532-23. https://doi.org/10.1128/spectrum.00532-23
Toljić B, Milašin J, de Luka SR, Dragović G, Jevtović Đ, Maslać A, Ristić-Đurović J, Trbovich AM. HIV-Infected Patients as a Model of Aging. in Microbiology Spectrum. 2023;11(3):e00532-23. doi:10.1128/spectrum.00532-23 .
Toljić, Boško, Milašin, Jelena, de Luka, Silvio R., Dragović, Gordana, Jevtović, Đorđe, Maslać, Aleksandar, Ristić-Đurović, Jasna, Trbovich, Alexander M., "HIV-Infected Patients as a Model of Aging" in Microbiology Spectrum, 11, no. 3 (2023):e00532-23, https://doi.org/10.1128/spectrum.00532-23 . .